Code to reproduce the results of the paper "A hybrid spatiotemporal model of PCa dynamics and insights into optimal therapeutic strategies"

Dataset

Description

Code to reproduce the results of the paper "A hybrid spatiotemporal model of PCa dynamics and insights into optimal therapeutic strategies". The code was tested in Matlab 2022a, 2019a.

Code:

Call_Hybrid_Model.m - runs several batches of simulations for each treatment regime.

Hybrid_Model.m - the code for a single simulation.

Cell_Coverage_Comparison.m - generates the comparison with experimental data.

Also included are a number of .gif animations of cell distributions over time, with the following filename format:

[date of run]_[batch number]_[weeks before treatment]_[weeks of treatment]_[weeks_after_treatment]_[treatment name]_anim.gif

The following animations are included of 10 treatments with 3 versions (by duration):

20220906_0000_5_12_0_none_anim.gif
20220906_0000_5_12_0_enza_anim.gif
20220906_0000_5_12_0_caba_anim.gif
20220906_0000_5_12_0_ever_anim.gif
20220906_0000_5_12_0_enza_then_caba_anim.gif
20220906_0000_5_12_0_enza_then_ever_anim.gif
20220906_0000_5_12_0_enza_alt_caba_anim.gif
20220906_0000_5_12_0_enza_alt_ever_anim.gif
20220906_0000_5_12_0_enza_with_caba_anim.gif
20220906_0000_5_12_0_enza_with_ever_anim.gif

20220906_0000_5_18_0_none_anim.gif
20220906_0000_5_18_0_enza_anim.gif
20220906_0000_5_18_0_caba_anim.gif
20220906_0000_5_18_0_ever_anim.gif
20220906_0000_5_18_0_enza_then_caba_anim.gif
20220906_0000_5_18_0_enza_then_ever_anim.gif
20220906_0000_5_18_0_enza_alt_caba_anim.gif
20220906_0000_5_18_0_enza_alt_ever_anim.gif
20220906_0000_5_18_0_enza_with_caba_anim.gif
20220906_0000_5_18_0_enza_with_ever_anim.gif

20220906_0000_5_52_0_none_anim.gif
20220906_0000_5_52_0_enza_anim.gif
20220906_0000_5_52_0_caba_anim.gif
20220906_0000_5_52_0_ever_anim.gif
20220906_0000_5_52_0_enza_then_caba_anim.gif
20220906_0000_5_52_0_enza_then_ever_anim.gif
20220906_0000_5_52_0_enza_alt_caba_anim.gif
20220906_0000_5_52_0_enza_alt_ever_anim.gif
20220906_0000_5_52_0_enza_with_caba_anim.gif
20220906_0000_5_52_0_enza_with_ever_anim.gif

 
Date made available2022
PublisherZenodo

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