Personal profile
Biography
Ant graduated from Bangor University with a BSc (Hons) in Sports Science and an MSc in Exercise Rehabilitation. He was awarded his PhD from the University of Exeter in 2015. Shortly after starting a post-doctoral research positon and teaching fellow post at the university of Exeter Medical School. He joined the School of Sports Health and Exercise science, here at the University of Portsmouth in 2016 as a Lecturer in Physical Activity, Exercise and Health.
His current role involves supervising a team of PhD students and post-doctoral researchers. He also lecturer in Advanced Sports Nutrition, Clinical Exercise Physiology and consults for professional sports teams.
During his career, he has designed bespoke training programmes and / or run clinical trials in a range of different clinical conditions including; type 2 diabetes mellitus, stroke, chronic obstructive pulmonary disease, cystic fibrosis and rheumatoligcal disorders such as raynaud’s phenomenon.
Research Interests
Ant Shepherd is an Associate Professor in Clinical Exercise Physiology whose research is dedicated to improving metabolic and cardiovascular health, physical function, and overall quality of life across a range of clinical and at‑risk populations. His work centres on translating innovative, evidence‑based interventions—such as targeted nutritional strategies and passive heating paradigms, and controlled exposure to extreme or atypical environments—into practical approaches that can deliver meaningful ‘patient’ benefit.
A key thread running through Ant’s research is the integration of mechanistic physiology with applied clinical science. He is particularly interested in understanding the pathophysiological processes underpinning chronic diseases, including cardiometabolic disorders and conditions characterised by impaired metabolic flexibility. By probing these underlying mechanisms, his work aims to identify novel therapeutic targets and optimise interventions that can be deployed in clinical and community settings.
Ant collaborates widely across disciplines including nutrition science, environmental physiology, rehabilitation medicine, and biomedical engineering. His research contributions span acute experimental studies through to longer‑term intervention trials, with a consistent focus on enhancing patient outcomes, informing clinical practice, and shaping public health guidance.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Physiotherapist-led weight management for people with osteoarthritis: a scoping review
Steele-Turner, B., Gonçalves, A. C., Shepherd, A. I., Drummond, H., Allison, K., Bennell, K. L. & Exell, T. A., 1 Jan 2026, In: Osteoarthritis and Cartilage. 34, 1, p. 121-138Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
The dose–response effects of nitrate-rich beetroot ingestion on cardiovascular and endothelial function: a randomised controlled trial
McLellan, A. G., Acton, J. P., O'Donnell, E., Rowland, S. N., Shepherd, A. I., Perissiou, M., James, L. J., Clifford, T. & Bailey, S. J., 13 Feb 2026, (Early online) In: Food & Function.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
The effects of nitrate on brown fat fraction and activation in older adults with type 2 diabetes: a randomised, double-blind, placebo-controlled crossover trial
Neal, R. A., Corbett, J., Costello, J., Saynor, Z., Eglin, C., Perissiou, M., Cummings, M. H., Price, H. C., Bailey, S., Velan, S. S., Sadananthan, S. A., Totman, J. J., Rennell-Smyth, J. & Shepherd, A., 1 Mar 2026, In: European Journal of Sport Science. 26, 3, 12 p., e70117.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Cardiovascular function in people with cystic fibrosis on Elexacaftor/Tezacaftor/Ivacaftor: A cross-sectional, observational, single-centre study
Clayton, L. J., Shepherd, A. I., Corbett, J., Perissiou, M., Connett, G., Legg, J., Allenby, M., Daniels, T., Urquhart, D. S., Mackintosh, K. A., McNarry, M. A. & Saynor, Z. L., 15 Feb 2025, (Early online) In: Journal of Cystic Fibrosis. 24, p. 801-808 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Downloads (Pure) -
Head‐down tilt lithotomy position and well‐leg compartment syndrome: an international survey of current practice
Uzoma, C. C., Shepherd, A. I., Saynor, Z. L., Khan, J. S., Piozzi, G. N., Duhoky, R., Askew, C., Ozmen, M. M., Middleton, T. R. F., Masum, S. & Perissiou, M., 7 Jun 2025, In: Colorectal Disease. 27, 6, 9 p., e70134.Research output: Contribution to journal › Article › peer-review
Open AccessFile30 Downloads (Pure)
Datasets
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Dataset for Chronic HWI and Cognitive Function
Piccolo, D. D. (Creator) & Shepherd, A. (Creator), University of Portsmouth, 17 Dec 2025
DOI: 10.17029/6ed6cf5d-d598-4a39-8d07-46a06441eb7f
Dataset
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Dataset for Chronic HWI and Muscle Function
Piccolo, D. D. (Creator) & Shepherd, A. (Creator), University of Portsmouth, 17 Dec 2025
DOI: 10.17029/40adb0f3-23ed-48c0-9cd3-ff7083c9d2f4
Dataset
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Dataset for 'Effect of acute passive heating on glucose tolerance and cardiovascular function in people with Type 2 diabetes: A randomised, balanced crossover, control trial.'
Shepherd, A. (Creator) & James, T. (Creator), University of Portsmouth, 20 Aug 2020
DOI: 10.17029/fbdc9fdd-6ecc-40ef-b318-0f49aa33ce1d
Dataset
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HWI and T2DM vascular and cardiac function
Shepherd, A. (Creator) & James, T. (Creator), University of Portsmouth, 2 Oct 2023
DOI: 10.17029/2352a4f8-3675-4def-ad75-c1b00901975d
Dataset
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HWI and T2DM metabolic function
Shepherd, A. (Creator) & James, T. (Creator), University of Portsmouth, 2 Oct 2023
DOI: 10.17029/3678c2c4-cecd-4aa3-a63b-21a57be082ec
Dataset
File
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The effect of a novel ketone esters and ‘climate adaptation’ drink in people with type 2 diabetes
Shepherd, A. (PI), Corbett, J. (CoI), Costello, J. (CoI), Perissiou, M. (CoI) & Williams, T. (CoI)
1/04/25 → 30/09/28
Project: Research
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Diabetes and extreme heat events: Mitigating cardiovascular risk
Perissiou, M. (PI), Costello, J. (CoI) & Shepherd, A. (CoI)
31/03/25 → 30/03/26
Project: Research
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The effects of sauna on sleep and climate adaptation
Shepherd, A. (PI), Corbett, J. (CoI), Middleton, T. (CoI), Perissiou, M. (CoI) & Simms, C. (CoI)
1/01/25 → 31/01/29
Project: Research
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The impact of Covid-19 on cardiac rehabilitation participants and staff
Witcher, C. (PI), Saynor, Z. (Team Member), Perissiou, M. (Team Member), Shepherd, A. (Team Member), Gorczynski, P. (Team Member) & Scott, A. (Team Member)
8/02/21 → …
Project: Research
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The effect of passive heating on cognition, muscle and cardiovascular function in older adults
Shepherd, A. (PI)
1/01/25 → 31/12/25
Project: Research
Prizes
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Runner up-Inaugural annual review prize of the physiological society
Perissiou, M. (Recipient), Bailey, T. G. (Recipient), Saynor, Z. (Recipient), Shepherd, A. (Recipient), Harwood, A. E. (Recipient) & Askew, C. D. (Recipient), 1 Apr 2021
Prize: National/international honour
Press/Media
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Call for volunteers with type 2 diabetes to trial weight loss technology
9/06/22 → 1/07/22
12 items of Media coverage, 1 Media contribution
Press/Media: Research cited
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Beetroot fails to warm up those sensitive to cold
3/10/17 → 5/10/17
4 items of Media coverage
Press/Media: Research cited