Personal profile
Summary
I am a Senior Research Associate within the Enzyme Surface Array Group at the Centre for Enzyme Innovation (CEI) at the University of Portsmouth. As part of the P3EB Mission Hub project, I specialize in enzyme technologies for plastic deconstruction, focusing on optimizing enzyme surface array systems for high-throughput screening to accelerate the discovery of plastic-degrading enzymes and advance sustainable biotechnological solutions.
My expertise lies in structural biology, particularly in designing and implementing synthetic molecular switches with applications spanning bioprocessing and biosensing. I bring extensive experience in integrating structural nucleic acid technologies with bioinformatics and enzymology, allowing me to develop innovative approaches to complex biotechnological challenges.
I actively contribute to the research culture of CEI and the School of the Environment and Life Sciences by collaborating with commercial partners to translate research into real-world applications. In addition to my research, I support the supervision and mentoring of junior researchers and students, fostering collaboration and knowledge exchange within the scientific community.
Biography
I have been part of the University of Portsmouth’s research community since my undergraduate studies in Biochemistry (BSc Hons, 2015), followed by a funded MRes in Molecular Genetics in 2016. My interest in nucleic acid biology and biotechnology led me to pursue a BBSRC-funded Ph.D. under the supervision of Professor Anastasia Callaghan, where I explored the targeting of bacterial small RNAs for therapeutic applications. I completed my Ph.D. in 2021 and have since been engaged in interdisciplinary research including genomics, structural biology, enzymology, and biotechnology.
In addition to my research expertise, I have experience in computer programming (Python) and databases, data-driven decision-making, and analytical problem-solving. This diverse background strengthen my approach to innovation and collaboration, allowing me to work effectively with researchers across multiple disciplines.
Research Interests
Another key area of my research interest is the application of artificial intelligence in science. I am a strong advocate for AI and proficient in leveraging it effectively to enhance research and innovation, with a focus on improving synthetic biology, mapping gene expression and advancing gene therapy development.
Beyond my core research, I care deeply about the ethical and policy challenges of scientific innovation. I am especially committed to exploring how biotechnology can be used responsibly to tackle global environmental issues and create a more sustainable future.
Education/Academic qualification
Ph.D., Therapeutic targeting of the small RNA GcvB in Actinobacillus pleuropneumoniae, University of Portsmouth
Award Date: 27 May 2021
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 4 Quality Education
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SDG 17 Partnerships for the Goals
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Collaborations and top research areas from the last five years
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Generation of functional-RNA arrays by in vitro transcription and in situ RNA capture for the detection of RNA-RNA interactions
Vincent, H., Henderson, C., Lopes Cardoso, D. & Callaghan, A., 1 Mar 2023, DNA Manipulation and Analysis. Scarlett, G. (ed.). Humana Press, p. 163-184 22 p. (Methods in Molecular Biology; vol. 2633).Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review
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Identification of small RNAs associated with RNA chaperone Hfq reveals a new stress response regulator in Actinobacillus pleuropneumoniae
da Silva, G. C., Rossi, C. C., Rosa, J. N., Sanches, N. M., Cardoso, D. L., Li, Y., Witney, A. A., Gould, K. A., Fontes, P. P., Callaghan, A. J., Bossé, J. T., Langford, P. R. & Bazzolli, D. M. S., 4 Oct 2022, In: Frontiers in Microbiology. 13, 20 p., 1017278.Research output: Contribution to journal › Article › peer-review
Open AccessFile86 Downloads (Pure) -
Relating protein functional diversity to cell type number identifies genes that determine dynamic aspects of chromatin organisation as potential contributors to organismal complexity
Lopes Cardoso, D. & Sharpe, C., 25 Sept 2017, In: PLoS One. 12, 9, 16 p., e0185409.Research output: Contribution to journal › Article › peer-review
Open AccessFile205 Downloads (Pure)
Thesis
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Therapeutic targeting of the small RNA GcvB in Actinobacillus pleuropneumoniae
Lopes Cardoso, D. (Author), McGeehan, J. E. (Supervisor), Callaghan, A. J. (Supervisor), Pickford, A. R. (Supervisor) & Sharpe, C. R. (Supervisor), Mar 2021Student thesis: Doctoral Thesis
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Datasets
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Supporting data (S2) for 'Changes to functional diversity in protein coding genes identify information flow as a determinant of organismal complexity'.
Sharpe, C. (Creator), Lopes Cardoso, D. (Contributor) & Dean, J. (Creator), University of Portsmouth, 30 Apr 2019
DOI: 10.17029/3d3b91c7-3ae2-4ef8-9703-852709d04a8f
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Projects
- 1 Finished
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Elucidating The Biological Role Of i-Motif DNA Structures In Vertebrate Genomes
Robson, S. (PI), Scarlett, G. (CoI), Myers, F. (CoI), Brazier, J. (CoI), Guille, M. (Team Member) & Lopes Cardoso, D. (Team Member)
1/09/22 → 31/08/24
Project: Research