Personal profile
Biography
Darek Gorecki was born in Warsaw, Poland where he read medicine and obtained his PhD. His key research interest is pathogenesis of Duchenne muscular dystrophy. He started research in this area as a post-doctoral fellow in the Molecular Neurobiology Unit, University of Cambridge under Professor Eric A Barnard, FRS. He continued it at the Royal Free & University College Medical School in London working as a research fellow and later obtained a personal Wellcome Trust Research Career Development Fellowship. After moving to his present laboratory in Portsmouth he has worked as a Senior Lecturer, Reader and, since 2007, Professor of Molecular Medicine. He is the Director of Research in the School of Pharmacy and Biomedical Sciences. In 2011 he won Distinguished Fulbright Scholarship to work at Harvard Medical School, USA researching the role of specific ATP receptors in muscular dystrophy.
For more information about my research please visit my lab page.
Research Interests
Pathogenesis and treatment of Duchenne muscular dystrophy, role of the dystrophin complex in the brain, purinoceptors, gene therapy using non-viral vectors.
Fingerprint
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Collaborations and top research areas from the last five years
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Anti-breast cancer effects of a novel derivative of biopigment from Serratia marcescens evoked by mitochondrial pathway-mediated apoptosis
Liu, M., Wu, S., Zhang, J., Yang, J., Chen, J., Górecki, D. C. & Zeng, Z., 1 Nov 2025, In: Biochemical Pharmacology. 241, 15 p., 117123.Research output: Contribution to journal › Article › peer-review
Open Access -
Deficient astrocyte homeostatic support contributes to brain impairment in Duchenne muscular dystrophy
Gorecki, D. C., Patel, A. M., Pomeroy, J. & Verkhratsky, A., 1 Aug 2025, In: Neurochemical Research. 50, 4, 18 p., 213.Research output: Contribution to journal › Article › peer-review
Open Access -
Differential effect of P2X7 receptors on proliferation and migration of human keratinocytes and dermal fibroblasts
Soszyńska, M., Komorowski, M., Łuszczyński, K., Radziszewski, M., Krześniak, N., Shevchenko, K., Górecki, D. C., Malejczyk, J. & Ścieżyńska, A., 3 Sept 2025, In: International Journal of Molecular Sciences. 26, 17, 12 p., 8548.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Downloads (Pure) -
Is dystrophin immunogenicity a barrier to advancing gene therapy for Duchenne muscular dystrophy?
Górecki, D. C., Kalinski, P. & Pomeroy, J., 3 Apr 2025, (Early online) In: Gene Therapy.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Downloads (Pure) -
Spatiotemporal diversity in molecular and functional abnormalities in the mdx dystrophic brain
Pomeroy, J., Borczyk, M., Kawalec, M., Hajto, J., Carlson, E., Svärd, S., Verma, S., Bareke, E., Boratyńska-Jasińska, A., Dymkowska, D., Mellado-Ibáñez, A., Laight, D., Zabłocki, K., Occhipinti, A., Majewska, L., Angione, C., Majewski, J., Yegutkin, G. G., Korostynski, M. & Zabłocka, B. & 1 others, , 20 Mar 2025, In: Molecular Medicine. 31, 1, 33 p., 108.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Downloads (Pure)
Datasets
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Dataset: RNA-seq comparison of immortalised myoblasts from dystrophic and WT mice
Robson, S. (Creator), Gosselin, M. R. F. (Contributor) & Gorecki, D. (Contributor), European Bioinformatics Institute, 20 Sept 2019
DOI: 10.1016/j.bbadis.2019.01.002, https://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-7287/
Dataset
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Additional file 1 of α-Dystrobrevin knockout mice have increased motivation for appetitive reward and altered brain cannabinoid receptor 1 expression
Hawkes, C. A. (Creator), Heath, C. J. (Creator), Sharp, M. M. (Creator), Górecki, D. C. (Creator) & Carare, R. O. (Creator), Figshare, 2022
DOI: 10.6084/m9.figshare.20762858.v1, https://springernature.figshare.com/articles/figure/Additional_file_1_of_-Dystrobrevin_knockout_mice_have_increased_motivation_for_appetitive_reward_and_altered_brain_cannabinoid_receptor_1_expression/20762858/1
Dataset
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Data availability statement for 'P2RX7 Purinoceptor as a therapeutic target - the second coming?'.
Young, C. N. J. (Creator) & Gorecki, D. (Creator), Frontiers Media S. A., 28 Jun 2018
Dataset
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Spatiotemporal diversity in molecular and functional abnormalities in the mdx dystrophic brain
Pomeroy, J. (Creator), Borczyk, M. (Creator), Kawalec, M. (Creator), Hajto, J. (Creator), Carlson, E. (Creator), Svärd, S. (Creator), Verma, S. (Creator), Bareke, E. (Creator), Boratyńska-Jasińska, A. (Creator), Dymkowska, D. (Creator), Mellado-Ibáñez, A. (Creator), Laight, D. (Creator), Zabłocki, K. (Creator), Occhipinti, A. (Creator), Majewska, L. (Creator), Angione, C. (Creator), Majewski, J. (Creator), Yegutkin, G. G. (Creator), Korostynski, M. (Creator), Zabłocka, B. (Creator) & Górecki, D. C. (Creator), Figshare, 21 Mar 2025
DOI: 10.6084/m9.figshare.c.7730471, https://springernature.figshare.com/collections/Spatiotemporal_diversity_in_molecular_and_functional_abnormalities_in_the_mdx_dystrophic_brain/7730471
Dataset
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Additional file 2 of α-Dystrobrevin knockout mice have increased motivation for appetitive reward and altered brain cannabinoid receptor 1 expression
Hawkes, C. A. (Creator), Heath, C. J. (Creator), Sharp, M. M. (Creator), Górecki, D. C. (Creator) & Carare, R. O. (Creator), Figshare, 2022
DOI: 10.6084/m9.figshare.20762861.v1, https://springernature.figshare.com/articles/figure/Additional_file_2_of_-Dystrobrevin_knockout_mice_have_increased_motivation_for_appetitive_reward_and_altered_brain_cannabinoid_receptor_1_expression/20762861/1
Dataset
Projects
- 11 Finished
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Synthetic biology for the development of a novel armour material based upon limpet tooth
Gorecki, D. (PI) & Rumney, R. (CoI)
16/01/23 → 15/01/24
Project: Research
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Elements of Bioremediation, Biomanufacturing and Bioenergy E3B
Gorecki, D. (PI) & Rumney, R. (CoI)
Biotechnology and Biological Sciences Research Council
1/11/22 → 15/01/23
Project: Research
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Investigating repurposed drugs to decrease the progression of Ewing’s sarcoma
Gorecki, D. (PI) & Rumney, R. (CoI)
Children's Cancer and Leukaemia Group
1/02/21 → 31/07/22
Project: Research
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P2X7: The front line therapeutic in soft tissue trauma (Wound Healing)
Gorecki, D. (PI) & Rumney, R. (CoI)
Defence Science and Technology Laboratory
1/11/19 → 30/09/21
Project: Research
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P2RX7 receptor: the re-discovered therapeutic target in inflammatory diseases and cancer
Gorecki, D. (PI)
1/03/18 → 30/03/22
Project: Research
Activities
- 1 Participation in conference
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44th European Muscle Conference
Gorecki, D. (Presented paper)
21 Sept 2016 → 25 Sept 2016Activity: Participating in or organising an event types › Participation in conference
Press/Media
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Tiny blood vessels in the brain could be the key in treating vascular dementia
22/06/17
1 item of Media coverage
Press/Media: Research cited
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