Research outputs per year
Research outputs per year
- 1 - 50 out of 75 results
Search results
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2024
Differential expression of DMD transcripts as a novel prognostic biomarker in histologically diverse mesotheliomas
Alnassar, N., Derry, J. M. J., Banna, G. L. & Gorecki, D. C., 29 Apr 2024, In: Translational Lung Cancer Research. 13, 4, p. 733-748Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Downloads (Pure) -
Investigating the involvement of C−X−C Motif Chemokine 5 and P2X7 purinoceptor in ectopic calcification in mouse models of Duchenne muscular dystrophy
Rumney, R. M. H., Pomeroy, J. & Górecki, D. C., 25 Jun 2024, (Early online) In: Journal of Cellular Biochemistry. 11 p., e30617.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Downloads (Pure) -
The P2×7 receptor is a master regulator of microparticle and mitochondria exchange in mouse microglia
Falzoni, S., Vultaggio-Poma, V., Chiozzi, P., Tarantini, M., Adinolfi, E., Boldrini, P., Giuliani, A. L., Morciano, G., Tang, Y., Gorecki, D. & Di Virgilio, F., 17 Apr 2024, (Early online) In: Function.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Downloads (Pure) -
2023
Automated multi-sample DNA extraction for genotyping live Xenopus embryos
Alles, N., Guille, M. & Górecki, D. C., 1 Mar 2023, In: Developmental Dynamics. 252, 3, p. 429-438 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile66 Downloads (Pure) -
Downregulation of dystrophin expression occurs across diverse tumors, correlates with the age of onset, staging and reduced survival of patients
Alnassar, N., Borczyk, M., Tsagkogeorga, G., Korostynski, M., Han, N. & Górecki, D. C., 21 Feb 2023, In: Cancers. 15, 5, 28 p., 1378.Research output: Contribution to journal › Article › peer-review
Open AccessFile60 Downloads (Pure) -
Primary mouse myoblast metabotropic purinoceptor profiles and calcium signalling differ with their muscle origin and are altered in mdx dystrophinopathy
Róg, J., Oksiejuk, A., Górecki, D. C. & Zabłocki, K., 1 Dec 2023, In: Scientific Reports. 13, 1, 18 p., 9333.Research output: Contribution to journal › Article › peer-review
Open AccessFile41 Downloads (Pure) -
The P2X7 purinoceptor in pathogenesis and treatment of dystrophino- and sarcoglycanopathies
Gόrecki, D. C. & Rumney, R. M. H., 1 Apr 2023, In: Current Opinion in Pharmacology. 69, 8 p., 102357.Research output: Contribution to journal › Article › peer-review
Open AccessFile50 Downloads (Pure) -
The role of P2X7 purinoceptors in the pathogenesis and treatment of muscular dystrophies
Zabłocki, K. & Górecki, D. C., 29 May 2023, In: International Journal of Molecular Sciences. 24, 11, 15 p., 9434.Research output: Contribution to journal › Article › peer-review
Open AccessFile52 Downloads (Pure) -
2022
Biomimetic generation of the strongest known biomaterial found in limpet tooth
Rumney, R. M. H., Robson, S., Kao, A., Barbu, E., Bozycki, L., Smith, J., Cragg, S., Couceiro, F., Parwani, R. N., Tozzi, G., Stuer, M., Barber, A. H., Ford, A. & Gorecki, D., 7 Jul 2022, In: Nature Communications. 13, 13 p., 3753.Research output: Contribution to journal › Article › peer-review
Open AccessFile72 Downloads (Pure) -
Loss of full-length dystrophin expression results in major cell-autonomous abnormalities in proliferating myoblasts
Gosselin, M. R. F., Mournetas, V., Borczyk, M., Verma, S., Occhipinti, A., Róg, J., Bozycki, L., Korostynski, M., Robson, S. C., Angione, C., Pinset, C. & Gorecki, D. C., 27 Sept 2022, In: eLife. 11, 43 p., e75521.Research output: Contribution to journal › Article › peer-review
Open AccessFile43 Downloads (Pure) -
P2X7 Purinoceptor Affects Ectopic Calcification of Dystrophic Muscles
Rumney, R. M. H., Róg, J., Chira, N., Kao, A. P., Al-Khalidi, R. & Górecki, D. C., 14 Jul 2022, In: Frontiers in Pharmacology. 13, 12 p., 935804.Research output: Contribution to journal › Article › peer-review
Open AccessFile80 Downloads (Pure) -
Specific dystrophins selectively associate with inhibitory and excitatory synapses of the mouse cerebellum and their loss alters expression of P2X7 purinoceptors and pro-inflammatory mediators
Jackson, T., Seifi, M., Górecki, D. C. & Swinny, J. D., 1 Oct 2022, In: Cellular and Molecular Neurobiology. 42, p. 2357-2377 21 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile87 Downloads (Pure) -
α-Dystrobrevin knockout mice have increased motivation for appetitive reward and altered brain cannabinoid receptor 1 expression
Hawkes, C. A., Heath, C. J., Sharp, M. M., Górecki, D. C. & Carare, R. O., 31 Aug 2022, In: Acta Neuropathologica Communications. 10, 1, 15 p., 127.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Downloads (Pure) -
2021
Myogenesis modelled by human pluripotent stem cells: a multi‐omic study of Duchenne myopathy early onset
Mournetas, V., Massouridès, E., Dupont, JB., Kornobis, E., Polvèche, H., Jarrige, M., Dorval, A. R. L., Gosselin, M. R. F., Manousopoulou, A., Garbis, S. D., Górecki, D. C. & Pinset, C., 17 Feb 2021, In: Journal of Cachexia, Sarcopenia and Muscle. 12, 1, p. 209-232 24 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile124 Downloads (Pure) -
The α-dystrobrevins play a key role in maintaining the structure and function of the extracellular matrix–significance for protein elimination failure arteriopathies
Sharp, M. M., Cassidy, J., Thornton, T., Lyles, J., Keable, A., Gatherer, M., Yasui, M., Abe, Y., Shibata, S., Weller, R. O., Górecki, D. C. & Carare, R. O., 1 Dec 2021, In: Acta Neuropathologica Communications. 9, 1, 15 p., 171.Research output: Contribution to journal › Article › peer-review
Open AccessFile39 Downloads (Pure) -
2020
Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in human lung microvascular endothelial cells controls oxidative stress, reactive oxygen-mediated cell signaling and inflammatory responses
Khalaf, M., Scott-Ward, T., Causer, A., Saynor, Z., Shepherd, A., Górecki, D., Lewis, A., Laight, D. & Shute, J., 29 Jul 2020, In: Frontiers in Physiology. 11, 20 p., 879.Research output: Contribution to journal › Article › peer-review
Open AccessFile153 Downloads (Pure) -
Engineering butylglyceryl-modified polysaccharides towards nanomedicines for brain drug delivery
Bostanudin, M. F. B., Lalatsa, K., Gorecki, D. & Barbu, E., 15 May 2020, In: Carbohydrate Polymers. 236, 10 p., 116060.Research output: Contribution to journal › Article › peer-review
Open AccessFile156 Downloads (Pure) -
Total absence of dystrophin expression exacerbates ectopic myofiber calcification and fibrosis and alters macrophage infiltration patterns
Young, C., Gosselin, M. R. F., Rumney, R. M. H., Oksiejuk, A., Chira, N., Bozycki, L., Matryba, P., Łukasiewicz, K., Kao, A., Dunlop, J. N., Robson, S., Zabłocki, K. & Gorecki, D., 1 Jan 2020, In: American Journal of Pathology. 190, 1, p. 190-205 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile145 Downloads (Pure) -
2019
Butylglyceryl pectin nanoparticles: synthesis, formulation and characterization
Bostanudin, M. F., Arafat, M., Sarfraz, M., Górecki, D. C. & Barbu, E., 2 May 2019, In: Polymers. 11, 5, 12 p., 789.Research output: Contribution to journal › Article › peer-review
Open AccessFile117 Downloads (Pure) -
Dystrophic mdx mouse myoblasts exhibit elevated ATP/UTP-evoked metabotropic purinergic responses and alterations in calcium signalling
Róg, J., Oksiejuk, A., Gosselin, M. R. F., Brutkowski, W., Dymkowska, D., Nowak, N., Robson, S., Górecki, D. C. & Zabłocki, K., 24 Jan 2019, (Early online) In: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.Research output: Contribution to journal › Article › peer-review
Open AccessFile220 Downloads (Pure) -
P2X7 purinoceptor as a therapeutic target in muscular dystrophies
Górecki, D. C., 1 Aug 2019, In: Current Opinion in Pharmacology. 47, p. 40-45 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile288 Downloads (Pure) -
2018
Proteomics analysis reveals a potential new target protein for lipid-lowering effect of Berberine8998
Yu, C., Liu, G., Liu, X., Gui, Y., Liu, H., Zheng, H., Gorecki, D., Patel, A. V., Yu, C. & Wang, Y., 1 Sept 2018, In: Acta Pharmacologica Sinica. 39, p. 1473-1482 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile136 Downloads (Pure) -
Sustained activation of P2X7 induces MMP-2-evoked cleavage and functional purinoceptor inhibition
Young, C. N. J., Chira, N., Róg, J., Al-Khalidi, R., Benard, M., Galas, L., Chan, P., Vaudry, D., Zabłocki, K. & Górecki, D. C., 1 Jun 2018, In: Journal of Molecular Cell Biology. 10, 3, p. 229-242 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile200 Downloads (Pure) -
Zidovudine ameliorates pathology in the mouse model of Duchenne muscular dystrophy via P2RX7 purinoceptor antagonism
Al-Khalidi, R., Panicucci, C., Cox, P., Chira, N., Róg, J., Young, C., Lloyd, R., Ambati, K., Ambati, J., Zabłocki, K., Gazzerro, E., Arkle, S., Bruno, C. & Gorecki, D., 11 Apr 2018, (Early online) In: Acta Neuropathologica Communications. 6, 17 p., 27.Research output: Contribution to journal › Article › peer-review
Open AccessFile141 Downloads (Pure) -
2017
Co-delivery of indoleamine 2,3-dioxygenase prevents loss of expression of an antigenic transgene in dystrophic mouse muscles
Sharma, D., Al-khalidi, R., Edgar, S., An, Q., Wang, Y., Young, C., Nowis, D. & Gorecki, D. C., Feb 2017, In: Gene Therapy. 24, 2, p. 113-119Research output: Contribution to journal › Article › peer-review
Open AccessFile238 Downloads (Pure) -
Investigations of octylglyceryl dextran-graft-poly(lactic acid) nanoparticles for peptide delivery to the brain
Boussahel, A., Ibegbu, D. M., Lamtahri, R., Maucotel, J., Chuquet, J., Lefranc, B., Leprince, J., Roldo, M., Le Mével, J-C., Gorecki, D. & Barbu, E., 1 Apr 2017, In: Nanomedicine. 12, 8, p. 879-892 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile268 Downloads (Pure) -
2016
Dystrophin: the dead calm of a dogma
Górecki, D. C., 18 Feb 2016, In: Rare Diseases. 4, 1, e1153777.Research output: Contribution to journal › Article › peer-review
Open AccessFile149 Downloads (Pure) -
Impact of P2RX7 ablation on the morphological, mechanical and tissue properties of bones in a murine model of duchenne muscular dystrophy
Mohamad, N. S., Sinadinos, A., Gorecki, D., Zioupos, P. & Tong, J., 3 Oct 2016, In: Journal of Biomechanics. 49, 14, p. 3444-3451Research output: Contribution to journal › Article › peer-review
Open AccessFile229 Downloads (Pure) -
2015
A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90
Young, C., Sinadinos, A., Lefebvre, A., Chan, P., Arkle, S., Vaudry, D. & Gorecki, D., 20 Feb 2015, In: Autophagy. 11, 1, p. 113-130 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile171 Downloads (Pure) -
Hollow-layered nanoparticles for therapeutic delivery of peptide prepared using electrospraying
Rasekh, M., Young, C., Roldo, M., Lancien, F., Le Mével, J-C., Hafizi, S., Ahmad, Z., Barbu, E. & Gorecki, D., 1 Nov 2015, In: Journal of Materials Science: Materials in Medicine. 26, 11Research output: Contribution to journal › Article › peer-review
Open AccessFile306 Downloads (Pure) -
Nanoparticles of alkylglyceryl-dextran-graft-poly(lactic acid) for drug delivery to the brain: preparation and in vitro investigation
Toman, P., Lien, C-F., Ahmad, Z., Dietrich, S., Smith, J. R., An, Q., Molnár, É., Pilkington, G. J., Górecki, D. C., Tsibouklis, J. & Barbu, E., 1 Sept 2015, In: Acta Biomaterialia. 23, 1, p. 250-262 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile456 Downloads (Pure) -
P2RX7 purinoceptor: a therapeutic target for ameliorating the symptoms of Duchenne muscular dystrophy
Sinadinos, A., Young, C. N. J., Al-Khalidi, R., Teti, A., Kalinski, P., Mohamad, S., Floriot, L., Henry, T., Tozzi, G., Jiang, T., Wurtz, O., Lefebvre, A., Shugay, M., Tong, J., Vaudry, D., Arkle, S., doRego, J-C. & Górecki, D. C., 13 Oct 2015, In: PLoS Medicine. 12, 10, 33 p., e1001888.Research output: Contribution to journal › Article › peer-review
Open AccessFile324 Downloads (Pure) -
Store-operated calcium entry contributes to abnormal Ca2+ signalling in dystrophic mdx mouse myoblasts
Onopiuk, M., Brutkowski, W., Young, C., Krasowska, E., Rog, J., Ritso, M., Wojciechowska, S., Arkle, S., Zablocki, K. & Gorecki, D. C., 1 Mar 2015, In: Archives of Biochemistry and Biophysics. 569, p. 1-9Research output: Contribution to journal › Article › peer-review
Open AccessFile340 Downloads (Pure) -
2014
Aberrant location of inhibitory synaptic marker proteins in the hippocampus of dystrophin-deficient mice
Krasowska, E., Zablocki, K., Gorecki, D. C. & Swinny, J. D., 2014, In: PLoS One. 9, 9, p. e108364 e108364.Research output: Contribution to journal › Article › peer-review
Open AccessFile182 Downloads (Pure) -
Receptory purynergiczne w prawidłowych i dystroficznych mięśniach szkieletowych
Translated title of the contribution :Purinergic receptors in skeletal muscles in health and in muscular dystrophy Research output: Contribution to journal › Article › peer-review
Open AccessFile166 Downloads (Pure) -
2013
CpG dinucleotide-specific hypermethylation of the TNS3 gene promoter in human renal cell carcinoma
Carter, J., Gorecki, D., Mein, C., Ljungberg, B. & Hafizi, S., Jul 2013, In: Epigenetics. 8, 7, p. 739-747 9 p.Research output: Contribution to journal › Article › peer-review
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2012
Absence of glial α-dystrobrevin causes abnormalities of the blood-brain barrier and progressive brain edema
Lien, C-F., Mohanta, S., Frontczak-Baniewicz, M., Swinny, J., Zablocka, B. & Gorecki, D., 30 Nov 2012, In: The Journal of Biological Chemistry. 287, 49, p. 41374-41385 12 p.Research output: Contribution to journal › Article › peer-review
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Expression, assembly and function of novel C-terminal truncated variants of the mouse P2X7 receptor: Re-evaluation of P2X7 knockouts
Masin, M., Young, C., Lim, K., Barnes, S. S., Xu, X. J., Marschall, V., Brutkowski, W., Mooney, E. R., Gorecki, D. & Murrell-Lagnado, R., Feb 2012, In: British Journal of Pharmacology. 165, 4, p. 978-993Research output: Contribution to journal › Article › peer-review
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In vitro assessment of alkylglyceryl-functionalized chitosan nanoparticles as permeating vectors for the blood–brain barrier
Lien, C., Molnar, E., Toman, P., Tsibouklis, J., Pilkington, G., Gorecki, D. & Barbu, E., 9 Apr 2012, In: Biomacromolecules. 13, 4, p. 1067-1073 7 p.Research output: Contribution to journal › Article › peer-review
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Mechano-Growth Factor: an important cog or a loose screw in the repair machinery?
Zabtocka, B., Goldspink, P., Goldspink, G. & Gorecki, D., Nov 2012, In: Frontiers in Experimental Endocrinology. 3, p. 131 1 p.Research output: Contribution to journal › Article › peer-review
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P2X7 purinoceptor alterations in dystrophic mdx mouse muscles: relationship to pathology and potential target for treatment
Young, C., Brutkowski, W., Lien, C., Arkle, S., Lochmuller, H., Zablocki, K. & Gorecki, D., May 2012, In: Journal of Cellular and Molecular Medicine. 16, 5, p. 1026-1037 12 p.Research output: Contribution to journal › Article › peer-review
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Relationship between the affinity of PEO-PPO-PEO block copolymers for biological membranes and their cellular effects
Redhead, M., Mantovani, G., Nawaz, S., Carbone, P., Gorecki, D., Alexander, C. & Bosquillon, C., 2012, In: Pharmaceutical Research. 29, 7, p. 1908-1918 11 p.Research output: Contribution to journal › Article › peer-review
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Splice-variants of the P2X7 receptor reveal differential agonist-dependence and functional coupling with pannexin-1
Xu, X. J., Boumechache, M., Robinson, L., Marschall, V., Gorecki, D., Masin, M. & Murrell-Lagnado, R., 15 Aug 2012, In: Journal of Cell Science. 125, 16, p. 3776-3789 14 p.Research output: Contribution to journal › Article › peer-review
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2011
Knockdown of MLC1 in primary astrocytes causes cell vacuolation: A MLC disease cell model
Duarri, A., De Heredia, M., Capdevila-Nortes, X., Ridder, M., Montolio, M., Lopez-Hernandez, T., Boor, I., Lien, C., Hagemann, T., Messing, A. & Gorecki, D., Jul 2011, In: Neurobiology of Disease. 43, 1, p. 228-238 11 p.Research output: Contribution to journal › Article › peer-review
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Rapid resolution liquid chromatography (RRLC) analysis for quality control of Rhodiola rosea roots and commercial standardized products
Ma., Y-C., Wang, X-Q., Hou, F., Ma, J., Luo, M., Lu, S., Jin, P., Terevsky, N., Chen, A., Xu, I., Sautreau, A. & Gorecki, D., May 2011, In: Natural Product Communications. 6, 5, p. 645-650Research output: Contribution to journal › Article › peer-review
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Simultaneous quantification of Echinacea species, Flos lonicerae, Radix scutellaria and Fructus forsythiae combinations by rapid resolution liquid chromatography
Ma, J., Ma, Y., Cai, C., Wang, D., Hou, F., Luo, M., Lu, S., Gorecki, D., Sautreau, A., Chen, A. & Jin, P., 2011, In: Natural Product Communications. 6, 5, p. 639-643 5 p.Research output: Contribution to journal › Article › peer-review
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Simultaneous quantification of Panax and Epimedium species using Rapid Resolution Liquid Chromatography (RRLC)
Ma, J., Ma, YC., Wang, D., Hou, F., Luo, M., Lu, S., Gorecki, D. & Sautreau, A., May 2011, In: Natural Product Communications. 6, 5, p. 581-586 6 p.Research output: Contribution to journal › Article › peer-review
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Targeting the GD3 acetylation pathway selectively induces apoptosis in glioblastoma
Birks, S., Danquah, J., King, L., Vlasak, R., Gorecki, D. & Pilkington, G., Sept 2011, In: Neuro-Oncology. 13, 9, p. 950-960 11 p.Research output: Contribution to journal › Article › peer-review
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2010
Changes in the expression of insulin-like growth factor 1 variants in the postnatal brain development and in neonatal hypoxia-ischaemia
Beresewicz, M., Majewska, M., Makarewicz, D., Vayro, S., Zablocka, B. & Gorecki, D., 2010, In: International Journal of Developmental Neuroscience. 28, 1, p. 91-97 7 p.Research output: Contribution to journal › Article › peer-review
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Toward drug delivery into the brain: synthesis, characterization, and preliminary in vitro assessment of alkylglyceryl-functionalized chitosan nanoparticles
Molnar, E., Barbu, E., Lien, C., Gorecki, D. & Tsibouklis, J., 2010, In: Biomacromolecules. 11, 11, p. 2880-2889 10 p.Research output: Contribution to journal › Article › peer-review