Research outputs per year
Research outputs per year
Personal profile
Biography
I studied BSc (Hons) Biochemistry & Pharmacology at Southampton University (1992-95), after an interest in the biology of genes and DNA was sparked during my A-level studies in Brighton. My doctoral work at Southampton (1995-98) was funded by the Cancer Research Campaign (now CRUK) and was carried out in the laboratory of Prof Keith Fox. Here I used DNA footprinting techniques to investigate the formation and stability of three-stranded (triplex) DNA structures. This was followed by a postdoctoral position at Bristol University (1998-2004) funded by the Wellcome Trust. Here, I worked in the laboratory of Prof Stephen Halford and examined DNA looping proteins, Type II restriction enzyme diversity, and DNA target-site location by proteins. I joined the staff of the School of Biological Sciences at University of Portsmouth in January 2005, where I am Senior Lecturer in Biochemistry.
For more information about my research please visit my lab page
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- QH301 Biology
- Genes, DNA, RNA, Protein, Molecular Biology, Enzymes, Kinetics
Fingerprint
Dive into the research topics where Darren Gowers is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
A lambda-exonuclease SELEX method for generating aptamers to bacterial targets
Gowland, R. & Gowers, D. M., 1 Mar 2023, DNA Manipulation and Analysis. Scarlett, G. (ed.). 1st ed. New York: Humana Press, p. 145-161 17 p. (Methods in Molecular Biology; vol. 2633).Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review
-
Classical recombinant DNA cloning
Mikić, A., Alomari, A. & Gowers, D. M., 1 Mar 2023, DNA Manipulation and Analysis. Scarlett, G. (ed.). 1st ed. New York: Humana Press, p. 1-24 24 p. (Methods in Molecular Biology; vol. 2633).Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review
-
An investigation into the potential of targeting Escherichia coli rne mRNA with locked nucleic acid (LNA) gapmers as an anti-bacterial strategy
Goddard, L., Mardle, C. E., Gneid, H., Ball, C. G., Gowers, D., Atkins, H. S., Butt, L., Watts, J. K., Vincent, H. & Callaghan, A., 4 Jun 2021, In: Molecules. 26, 11, p. 1-15 15 p., 3414.Research output: Contribution to journal › Article › peer-review
Open AccessFile91 Downloads (Pure) -
Identification of novel inhibitors of Escherichia coli DNA ligase
Alomari, A. M. A. M., Gowland, R. M. N., Southwood, C., Barrow, J., Bentley, Z., Calvin-Nelson, J., Kaminski, A., LeFevre, M., Callaghan, A., Vincent, H. & Gowers, D., 25 Apr 2021, In: Molecules. 26, 9, 14 p., 2508.Research output: Contribution to journal › Article › peer-review
Open AccessFile185 Downloads (Pure) -
Identification and analysis of novel small molecule inhibitors of RNase E: implications for antibacterial targeting and regulation of RNase E
Mardle, C. E., Goddard, L., Spelman, B. C., Atkins, H. S., Butt, L., Cox, P., Gowers, D., Vincent, H. & Callaghan, A., 9 Jun 2020, (Early online) In: Biochemistry and Biophysics Reports. 23, 100773.Research output: Contribution to journal › Article › peer-review
Open AccessFile174 Downloads (Pure)
Projects
- 3 Finished
-
Life 3D: A new tool for interactive visualisation of 3D models
Gowers, D. (PI), Powell, W. (CoI) & Powell, V. (CoI)
1/01/15 → 30/06/15
Project: Research
-
Molecular that use strucutred DNA for directed movement
Gowers, D. (PI) & Firman, K. (CoI)
Engineering and Physical Sciences Research Council
19/10/09 → 12/10/12
Project: Research
-
Location Of DNA Target Sites By Proteins And Nucleic Acids
Gowers, D. (PI)
Biotechnology and Biological Sciences Research Council
1/06/06 → 31/05/09
Project: Research
Press/Media
-
Faculty of Science open labs
Gowers, D., Pilkington, G. & Smith, J.
16/03/16
1 Media contribution
Press/Media: Expert comment