Research outputs per year
Research outputs per year
- 23 results
Search results
-
2021
An investigation into the potential of targeting Escherichia coli rne mRNA with locked nucleic acid (LNA) gapmers as an anti-bacterial strategy
Goddard, L., Mardle, C. E., Gneid, H., Ball, C. G., Gowers, D., Atkins, H. S., Butt, L., Watts, J. K., Vincent, H. & Callaghan, A., 4 Jun 2021, In: Molecules. 26, 11, p. 1-15 15 p., 3414.Research output: Contribution to journal › Article › peer-review
Open AccessFile90 Downloads (Pure) -
Identification of novel inhibitors of Escherichia coli DNA ligase
Alomari, A. M. A. M., Gowland, R. M. N., Southwood, C., Barrow, J., Bentley, Z., Calvin-Nelson, J., Kaminski, A., LeFevre, M., Callaghan, A., Vincent, H. & Gowers, D., 25 Apr 2021, In: Molecules. 26, 9, 14 p., 2508.Research output: Contribution to journal › Article › peer-review
Open AccessFile172 Downloads (Pure) -
2020
Identification and analysis of novel small molecule inhibitors of RNase E: implications for antibacterial targeting and regulation of RNase E
Mardle, C. E., Goddard, L., Spelman, B. C., Atkins, H. S., Butt, L., Cox, P., Gowers, D., Vincent, H. & Callaghan, A., 9 Jun 2020, (Early online) In: Biochemistry and Biophysics Reports. 23, 100773.Research output: Contribution to journal › Article › peer-review
Open AccessFile171 Downloads (Pure) -
2019
A structural and biochemical comparison of Ribonuclease E homologues from pathogenic bacteria highlights species-specific properties
Mardle, C. E., Shakespeare, T. J., Butt, L. E., Goddard, L. R., Gowers, D. M., Atkins, H. S., Vincent, H. A. & Callaghan, A. J., 28 May 2019, In: Scientific Reports. 9, 1, 11 p., 7952.Research output: Contribution to journal › Article › peer-review
Open AccessFile185 Downloads (Pure) -
2017
Inhibition of homologous phosphorolytic ribonucleases by citrate may represent an evolutionarily conserved communicative link between RNA degradation and central metabolism
Stone, C., Butt, L., Bufton, J., Lourenco, D. C., Gowers, D., Pickford, A., Cox, P., Vincent, H. & Callaghan, A., 5 May 2017, In: Nucleic Acids Research. 45, 8, p. 4655-4666Research output: Contribution to journal › Article › peer-review
Open AccessFile198 Downloads (Pure) -
2013
An improved method for surface immobilisation of RNA: application to small Non-Coding RNA - mRNA pairing
Vincent, H., Phillips, J., Henderson, C., Roberts, A. J., Stone, C., Mardle, C., Butt, L., Gowers, D., Pickford, A. & Callaghan, A., 14 Nov 2013, In: PLoS One. 8, 11, p. e79142Research output: Contribution to journal › Article › peer-review
Open AccessFile160 Downloads (Pure) -
Characterization of MicA interactions suggests a potential novel means of gene regulation by small non-coding RNAs
Henderson, C., Vincent, H., Stone, C., Phillips, J., Cary, P., Gowers, D. & Callaghan, A., 2013, In: Nucleic Acids Research. 41, 5, p. 3386-3397 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile158 Downloads (Pure) -
Hfq binding changes the structure of Escherichia coli small noncoding RNAs OxyS and RprA, which are involved in the riboregulation of rpoS
Henderson, C., Vincent, H., Casamento, A., Stone, C., Phillips, J., Cary, P., Sobott, F., Gowers, D., Taylor, J. E. N. & Callaghan, A., Aug 2013, In: RNA. 19, 8, p. 1089-1104 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile178 Downloads (Pure) -
2012
Characterization of Vibrio cholerae Hfq Provides Novel Insights into the Role of the Hfq C-Terminal Region
Vincent, H., Henderson, C., Ragan, T., Garza-Garcia, A., Cary, P., Gowers, D., Malfois, M., Driscoll, P., Sobott, F. & Callaghan, A., 29 Jun 2012, In: Journal of Molecular Biology. 420, 1-2, p. 56-69 14 p.Research output: Contribution to journal › Article › peer-review
-
Enhanced purification and characterization of the PfeIF4A (PfH45) helicase from Plasmodium Falciparum using a codon-optimised clone
Evans, L., Gowers, D., Firman, K. & Youell, J., Sept 2012, In: Protein Expression and Purification. 85, 1, p. 1-8 8 p.Research output: Contribution to journal › Article › peer-review
-
The low-resolution solution structure of Vibrio cholerae Hfq in complex with Qrr1 sRNA
Vincent, H., Henderson, C., Stone, C., Cary, P., Gowers, D., Sobott, F., Taylor, J. E. N. & Callaghan, A., 1 Dec 2012, In: Nucleic Acids Research. 40, 17, p. 8698-8710 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile272 Downloads (Pure) -
2007
Restriction endonucleases that bridge and excise two recognition sites from DNA
Marshall, J. J. T., Gowers, D. & Halford, S., 2007, In: Journal of Molecular Biology. 367, 2, p. 419-431 13 p.Research output: Contribution to journal › Article › peer-review
-
2005
Measurement of the contributions of 1D and 3D pathways to the translocation of a protein along DNA
Gowers, D., Wilson, G. G. & Halford, S., 2005, In: Proceedings of the National Academy of Sciences. 102, 44, p. 15883-15888 6 p.Research output: Contribution to journal › Article › peer-review
-
2004
One recognition sequence, seven restriction enzymes, five reaction mechanisms
Gowers, D., Bellamy, S. & Halford, S., 2004, In: Nucleic Acids Research. 32, 11, p. 3469-3479 11 p.Research output: Contribution to journal › Article › peer-review
-
2003
Protein motion from non-specific to specific DNA by three-dimensional routes aided by supercoiling
Gowers, D. & Halford, S., 2003, In: EMBO Journal. 22, 6, p. 1410-1418 9 p.Research output: Contribution to journal › Article › peer-review
-
2002
Heterogeneity and persistence length in human ocular mucins
Round, A., Berry, M., McMaster, T., Stoll, S., Gowers, D., Corfield, A. & Miles, M., Sept 2002, In: Biophysical Journal. 83, 3, p. 1661-1670 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile110 Downloads (Pure) -
2000
Alternative geometries of DNA looping: an analysis using the SfiI endonuclease
Watson, M., Gowers, D. & Halford, S., 2000, In: Journal of Molecular Biology. 298, 3, p. 461-475 15 p.Research output: Contribution to journal › Article › peer-review
-
Secondary binding sites for triplex-forming oligonucleotides containing bulges, loops, and mismatches in the third strand
Fox, K., Flashman, E. & Gowers, D., 2000, In: Biochemistry. 39, 22, p. 6714-6725 12 p.Research output: Contribution to journal › Article › peer-review
-
Two are better than one
Halford, S., Gowers, D. & Sessions, R., 2000, In: Nature Structural Biology. 7, 9, p. 705-707 3 p.Research output: Contribution to journal › Article › peer-review
-
1999
DNA triple helix formation at target sites containing several pyrimidine interruptions: Stabilization by protonated cytosine or 5-(1-propargylamino)dU
Gowers, D. M., Bijapur, J., Brown, T. & Fox, K. R., 24 Sept 1999, In: Biochemistry. 38, 41, p. 13747-13758 12 p.Research output: Contribution to journal › Article › peer-review
-
Restriction endonuclease reactions requiring two recognition sites
Halford, S. E., Bilcock, D. T., Stanford, N. P., Williams, S. A., Milsom, S. E., Gormley, N. A., Watson, M. A., Bath, A. J., Embleton, M. L., Gowers, D. M., Daniels, L. E., Parry, S. H. & Szczelkun, M. D., 1 Aug 1999, In: Biochemical Society Transactions. 27, 4, p. 696-699 4 p.Research output: Contribution to journal › Article › peer-review
-
1998
Triple helix formation at (AT)(n) adjacent to an oligopurine tract
Gowers, D. M. & Fox, K. R., 1 Aug 1998, In: Nucleic Acids Research. 26, 16, p. 3626-3633 8 p.Research output: Contribution to journal › Article › peer-review
Open Access -
1997
DNA triple helix formation at oligopurine sites containing multiple contiguous pyrimidines
Gowers, D. M. & Fox, K. R., 1 Oct 1997, In: Nucleic Acids Research. 25, 19, p. 3787-3794 8 p.Research output: Contribution to journal › Article › peer-review
Open Access