Research outputs per year
Research outputs per year
Personal profile
Summary
**Accepting self-funded PhD students**
Dr David Rusling is a Senior Lecturer in Pharmacology within the School of Pharmacy and Biomedical Sciences at the University of Portsmouth. His research focuses on the self-assembly and recognition of nucleic acid sequences from a biological, therapeutic and nanotech perspective. One of his long-term research projects is seeking to improve the triplex-forming properties of oligonucleotides, a class of DNA-binding agent capable of recognising unique base sequences within the major groove of double-helical DNA. Such molecules have potential to modulate the expression of specific genes, as well as introduce functionality into artificial DNA structures assembled for DNA nanotechnology. David’s recent research has appeared in several prominent journals, including Nucleic Acids Research, ACS Nano, Angewandte Chemie, and Chemical Communications.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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A third strand for protein–DNA interactions
Rusling, D. A. & Vasquez, K. M., 15 Oct 2024, In: Nature Chemistry. 16, p. 1748-1750 3 p.Research output: Contribution to journal › Comment/debate › peer-review
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Functionalizing DNA origami by triplex-directed site-specific photo-cross-linking
Kalra, S., Donnelly, A., Singh, N., Matthews, D., Del Villar-Guerra, R., Bemmer, V., Dominguez, C., Allcock, N., Cherny, D., Revyakin, A. & Rusling, D. A., 15 May 2024, In: Journal of the American Chemical Society. 146, 19, p. 13617–13628 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile69 Downloads (Pure) -
Fluorous-directed assembly of DNA origami nanostructures
Zou, J., Stammers, A. C., Taladriz-Sender, A., Withers, J. M., Christie, I., Santana Vega, M., Aekbote, B. L., Peveler, W. J., Rusling, D. A., Burley, G. A. & Clark, A. W., 10 Jan 2023, In: ACS Nano. 17, 1, p. 752-759 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile86 Downloads (Pure) -
The formation and displacement of ordered DNA triplexes in self-assembled three-dimensional DNA crystals
Zhao, Y., Chandrasekaran, A. R., Rusling, D. A., Woloszyn, K., Hao, Y., Hernandez, C., Vecchioni, S., Ohayon, Y. P., Mao, C., Seeman, N. C. & Sha, R., 2 Feb 2023, In: Journal of the American Chemical Society. 145, 6, p. 3599–3605Research output: Contribution to journal › Article › peer-review
Open AccessFile66 Downloads (Pure) -
Triplex-forming properties and enzymatic incorporation of a base-modified nucleotide capable of duplex DNA recognition at neutral pH
Rusling, D. A., 21 Jul 2021, In: Nucleic Acids Research. 49, 13, p. 7256-7266Research output: Contribution to journal › Article › peer-review
Open AccessFile176 Downloads (Pure)
Projects
- 1 Active
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Triplex DNA: The next platform for oligonucleotide drug development
1/07/24 → 30/06/26
Project: Research
Activities
- 1 Editorial activity
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Nucleic Acids Research (Journal)
Rusling, D. (Editor)
1 Jan 2024Activity: Publication peer-review and editorial work types › Editorial activity