Garry Scarlett

Search results

• 2023

  DNA Manipulation and Analysis

  Scarlett, G. (ed.), 1 Mar 2023, 1st ed. New York: Humana Press. 249 p. (Methods in Molecular Biology; vol. 2633)

  Research output: Book/Report › Book

• Preface

  Scarlett, G., 1 Mar 2023, DNA Manipulation and Analysis. Scarlett, G. (ed.). 1st ed. Humana Press, p. v-vi 2 p. (Methods in Molecular Biology; vol. 2633).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review
• 2021

  Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England

  The COVID-19 Genomics UK (COG-UK) Consortium, Volz, E., Robson, S. C., Beckett, A. H., Chauhan, A. J., Glaysher, S., Elliott, S., Bourgeois, Y., Scarlett, G. P., Loveson, K. F., Goudarzi, S., Fearn, C., Cook, K., Dent, H. & Paul, H., 13 May 2021, In: Nature. 593, 7858, p. 266-269 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Lineages 100%
  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • Gene 83%
  • Failure 83%
  • Target 83%
  43 Downloads (Pure)

• Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study

  COVID-19 Genomics UK (COG-UK) Consortium, Graham, M. S., Robson, S. C., Beckett, A. H., Chauhan, A. J., Glaysher, S., Elliott, S., Bourgeois, Y., Scarlett, G. P., Loveson, K. F., Goudarzi, S., Fearn, C., Cook, K., Dent, H. & Paul, H., 1 May 2021, In: The Lancet Public Health. 6, 5, p. e335-e345 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Reinfection 100%
  • Symptom 81%
  • symptoms 81%
  • Infection 45%
  • Severe Acute Respiratory Syndrome Coronavirus 2 36%
  38 Downloads (Pure)

• Evaluating the effects of SARS-CoV-2 spike mutation D614G on transmissibility and pathogenicity

  COG-UK Consortium, Robson, S. C., Beckett, A., Loveson, K. F., Chauhan, A. J., Glaysher, S., Elliott, S., Bourgeois, Y., Scarlett, G. P., Brooks, T. T., Williams, T. & Parker, M. D., 7 Jan 2021, In: Cell. 184, 1, p. 64-75

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Spike 100%
  • SARS Coronavirus 60%
  • Severe Acute Respiratory Syndrome Coronavirus 2 60%
  • patients 40%
  • Patient 40%
  72 Downloads (Pure)

• Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7

  The COVID-19 Genomics UK (COG-UK) Consortium, Meng, B., Robson, S. C., Loveson, K. F., Chauhan, A. J., Bourgeois, Y., Beckett, A. H., Goudarzi, S., Fearn, C., Cook, K., Dent, H., Paul, H. & Scarlett, G. P., 29 Jun 2021, In: Cell Reports. 35, 13, 24 p., 109292.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Spike 100%
  • Severe Acute Respiratory Syndrome Coronavirus 2 44%
  • infectivity 33%
  • Infection 33%
  • mutations 22%
  139 Downloads (Pure)
• 2020

  An integrated national scale SARS-CoV-2 genomic surveillance network

  The COVID-19 Genomics UK (COG-UK) Consortium, Robson, S., Scarlett, G., Bourgeois, Y. X. C. & Beckett, A. H., 1 Jul 2020, In: The Lancet Microbe. 1, p. e99-e100

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  File

  • coronaviruses 100%
  • diseases 50%
  • COVID-19 50%
  • Severe Acute Respiratory Syndrome Coronavirus 2 50%
  • workers 33%
  180 Downloads (Pure)

• CoronaHiT: large scale multiplexing of SARS-CoV-2 genomes using Nanopore sequencing

  The COVID-19 Genomics UK (COG-UK) Consortium, Robson, S., Scarlett, G., Bourgeois, Y. X. C., Beckett, A. H. & Loveson, K., 24 Jun 2020, bioRxiv.

  Research output: Working paper

  Open Access

  File

  • Sequencing 100%
  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • Sample 80%
  • Polymerase Chain Reaction 80%
  • cost 40%
  100 Downloads (Pure)

• COVID-19 infection dynamics in care homes in the East of England: a retrospective genomic epidemiology study

  The COVID-19 Genomics UK (COG-UK) Consortium, Robson, S., Scarlett, G., Bourgeois, Y. X. C., Beckett, A. H. & Loveson, K., 1 Sept 2020, medRxiv.

  Research output: Working paper

  Open Access

  • Resident 100%
  • covid-19 50%
  • COVID-19 50%
  • Severe Acute Respiratory Syndrome Coronavirus 2 50%
  • universities 33%

• Evaluating the effects of SARS-CoV-2 Spike mutation D614G on transmissibility and pathogenicity

  The COVID-19 Genomics UK (COG-UK) Consortium, Robson, S., Scarlett, G., Bourgeois, Y. X. C., Beckett, A. H. & Loveson, K., 1 Sept 2020, medRxiv.

  Research output: Working paper

  Open Access

  • Spike 100%
  • patients 25%
  • growth 25%
  • SARS Coronavirus 25%
  • Severe Acute Respiratory Syndrome Coronavirus 2 25%

• Genomic epidemiology of SARS-CoV-2 spread in Scotland highlights the role of European travel in COVID-19 emergence

  The COVID-19 Genomics UK (COG-UK) Consortium, Robson, S., Scarlett, G., Bourgeois, Y. X. C., Beckett, A. H. & Loveson, K., 9 Jun 2020, medRxiv.

  Research output: Working paper

  Open Access

  • COVID-19 100%
  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • travel 60%
  • scotland 60%
  • Travel 60%

• Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020

  The WHO European Region sequencing laboratories and GISAID EpiCoV group, Robson, S., Scarlett, G., Loveson, K. & Beckett, A. H., 13 Aug 2020, In: Eurosurveillance. 25, 32, 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • coronaviruses 50%
  • Cladistics 33%
  • Nomenclature 33%
  • Time 33%
  109 Downloads (Pure)

• Retrospective screening of routine respiratory samples revealed undetected community transmission and missed intervention opportunities for SARS-CoV-2 in the United Kingdom

  The COVID-19 Genomics UK (COG-UK) Consortium, Chappell, J. G., Tsoleridis, T., Clark, G., Berry, L., Holmes, N., Moore, C., Carlile, M., Sang, F., Debebe, J., Wright, V., Irving, W. L., Thomson, B. J., Boswell, T. C. J., Willingham, I., Joseph, A., Smith, W., Khakh, M., Fleming, V. M., Lister, M. M., & 10 othersHowson-Wells, H. C., Holmes, E. C., Loose, M., Ball, J. K., McClure, C. P., Robson, S., Scarlett, G., Bourgeois, Y. X. C., Beckett, A. H. & Loveson, K., 21 Aug 2020, medRxiv.

  Research output: Working paper

  Open Access

  • Virus 100%
  • viruses 62%
  • data 37%
  • testing 37%
  • communities 37%
• 2017

  A newly identified Rab-GDI paralogue has a role in neural development in amphibia

  Nazlamova, L., Noble, A., Schubert, F. R., Mcgeehan, J., Myers, F., Guille, M. & Scarlett, G., 30 Jan 2017, In: Gene. 599, p. 78–86

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Protein 100%
  • proteins 100%
  • Nested Gene 66%
  • Xenopus 66%
  • Embryogenesis 66%
  258 Downloads (Pure)

• RNA whole-mount In Situ Hybridization Proximity Ligation Assay (rISH-PLA), an assay for detecting RNA-protein complexes in intact cells

  Roussis, I. M., Myers, F. A. & Scarlett, G. P., 3 Mar 2017, (Early online) Current Protocols in Cell Biology. Nadkami, A. (ed.). Wiley Online Library, Vol. 74. Unit 17.20

  Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

  Open Access

  • rna 100%
  • RNA 70%
  • proteins 60%
  • in-situ hybridization 40%
  • in Situ Hybridization 40%
• 2016

  RNA whole-mount In situ Hybridisation Proximity Ligation Assay (rISH-PLA), an assay for detecting RNA-protein complexes in intact cells

  Roussis, I. M., Guille, M., Myers, F. A. & Scarlett, G. P., 29 Jan 2016, In: PLoS One. 11, 1, e0147967.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • rna 100%
  • RNA 66%
  • proteins 58%
  • in-situ hybridization 41%
  • in Situ Hybridization 41%
  420 Downloads (Pure)
• 2015

  Circular dichroism for the analysis of protein–DNA interactions

  Siligardi, G., Kneale, G. G. & Scarlett, G., 2015, DNA-protein interactions: principles and protocols. Leblanc, B. P. & Rodrigue, S. (eds.). 4 ed. Cham: Humana Press, p. 299-312 (Methods in molecular biology; vol. 1334).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

  Open Access

  • dichroism 100%
  • Circular Dichroism 100%
  • interactions 42%
  • information 28%
  • synchrotron radiation 28%

• Omega 3 (n−3) fatty acids down-regulate nuclear factor-kappa B (NF-κB) gene and blood cell adhesion molecule expression in patients with homozygous sickle cell disease

  Daak, A. A., Elderdery, A. Y., Elbashir, L. M., Mariniello, K., Mills, J., Scarlett, G., Elbashir, M. I. & Ghebremeskel, K., 1 Jun 2015, In: Blood Cells, Molecules, and Diseases. 55, 1, p. 48-55

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Omega-3 Fatty Acid 100%
  • Inpatient 80%
  • diseases 80%
  • inflammation 80%
  • fatty acids 80%
  200 Downloads (Pure)
• 2014

  An old dog and new tricks: genetic analysis of a Tudor dog recovered from the Mary Rose wreck

  Zouganelis, G. D., Ogden, R., Nahar, N., Runfola, V., Ashrafian Bonab, M., Ardalan, A., Radford, D. R., Barnett, R., Larson, G., Hildred, A., Jones, M. & Scarlett, G., 1 Dec 2014, In: Forensic Science International. 245, p. 51-57

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • dogs 100%
  • Dog 100%
  • animals 28%
  • ships 28%
  • Animal 28%
  585 Downloads (Pure)

• APTE: identification of indirect read-out A-DNA promoter elements in genomes

  Whitley, D. C., Runfola, V., Cary, P., Nazlamova, L., Guille, M. & Scarlett, G., 26 Aug 2014, In: BMC Bioinformatics. 15, 288

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Promoter Region 100%
  • Transcription Factor 83%
  • transcription factors 83%
  • promoters 83%
  • Xenopus 66%
  111 Downloads (Pure)
• 2009

  A-form DNA structure is a determinant of transcript levels from the Xenopus gata2 promoter in embryos

  Llewellyn, K., Cary, P., McClellan, J., Guille, M. & Scarlett, G., 2009, In: Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1789, 11-12, p. 675-680 6 p.

  Research output: Contribution to journal › Article › peer-review

  • dna 100%
  • transcription factors 100%
  • promoters 100%
  • Promoter Region 100%
  • Transcription Factor 100%
• 2008

  Methylation of Xilf3 by Xprmt1b alters its DNA, but not RNA, binding activity

  Cazanove, O., Batut, J., Scarlett, G., Mumford, K., Elgar, S., Thresh, S., Neant, I., Moreau, M. & Guille, M., 2008, In: Biochemistry. 47, 32, p. 8350-8357 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Methylation 100%
  • methylation 100%
  • Xenopus 83%
  • proteins 83%
  • Binding Affinity 66%
• 2006

  Identification of a structural and functional domain in xNAP1 involved in protein–protein interactions

  Friedeberg, C., Scarlett, G., McGeehan, J., Abu-Daya, A., Guille, M. & Kneale, G., 2006, In: Nucleic Acids Research. 34, 17, p. 4893-4899 7 p.

  Research output: Contribution to journal › Article › peer-review

  • proteins 100%
  • nucleosomes 100%
  • Nucleosome 100%
  • Protein Assembly 75%
  • interactions 50%
• 2004

  Intact RNA-binding domains are necessary for structure-specific DNA binding and transcription control by CBTF122 during Xenopus development

  Scarlett, G., Elgar, S., Cary, P., Noble, A., Oxford, R., Kneale, G. & Guille, M., Dec 2004, In: The Journal of Biological Chemistry. 279, 50, p. 52447-52455 9 p.

  Research output: Contribution to journal › Article › peer-review

  • rna 100%
  • dna 85%
  • transcription 57%
  • in vivo 42%
  • DNA Binding 42%
• 2003

  Characterization of anEco R 124I restriction-modification enzyme produced from a deleted form of the DNA-binding subunit, which results in a novel DNA specificity

  Abadjieva, A., Scarlett, G., Janscak, P., Dutta, C. F. & Firman, K., 2003, In: Folia Microbiologica. 48, 3, p. 319-328 10 p.

  Research output: Contribution to journal › Article › peer-review

  • dna 100%
  • DNA 66%
  • mutants 55%
  • methyl transferases 44%
  • endonucleases 33%
• 2002

  Structures of CUG Repeats in RNA: potential implications for human genetic diseases

  Pinheiro, P., Scarlett, G., Rodger, A., Rodger, P., Murray, A., Brown, T., Newbury, S. & McClellan, J., 2002, In: The Journal of Biological Chemistry. 277, 38, p. 35183-35190 8 p.

  Research output: Contribution to journal › Article › peer-review

  • rna 100%
  • RNA 100%
  • humans 50%
  • length 50%
  • control 50%
• 2000

  RNA-dependent cytoplasmic anchoring of a transcription factor subunit during Xenopus development

  Brzostowski, J., Robinson, C., Orford, R., Elgar, S., Scarlett, G., Peterkin, T., Malartre, M., Kneale, G., Wormington, M. & Guille, M., 17 Jul 2000, In: EMBO Journal. 19, 14, p. 3683-3693 11 p.

  Research output: Contribution to journal › Article › peer-review

  • rna 100%
  • Transcription Factor 75%
  • transcription factors 75%
  • translocation 75%
  • RNA Binding 50%
• 1993

  Tyr26 and Phe73 are essential for full biological activity of the Fd Gene 5 protein

  O'Donohue, M. J., Scarlett, G. P. & Kneale, G. G., 1 May 1993, In: FEMS Microbiology Letters. 109, 2-3, p. 219-223 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access