Jordi Cayuso Mas

Accepting PhD Students

PhD projects

- Role of Eph/Ephrin Signalling in Neural Regeneration
- Molecular Mechanisms of Fin Regeneration in Zebrafish
- Cell Signalling during Neural Tube Closure
- Eph/Ephrin Signalling and Neurodegeneration

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Personal profile


I am a cell and developmental biologist interested in understanding how cell-to-cell communication controls cell behaviour during development, regeneration and neurodegeneration. After my degree in Biology and a MRes at (University of Barcelona), I completed my PhD in Genetics with Dr Elisa Marti at the Molecular Biology Institute of Barcelona. There, I uncovered that through the transcriptional regulation of transcription factors, anti-apoptotic and cell cycle genes, Sonic Hedgehog coordinates the patterning, growth and differentiation of neural precursors and the switch between neurogenic and gliogenic programmes in the vertebrate neural tube.

During my first postdoc with Dr Elke Ober at the MRC National Institute for Medical Research (London), I started working on the Eph/Ephrin pathway, a signalling system involved in embryonic development and tissue homeostasis and with links to cancer and neurodegenerative diseases. My work in liver development, revealed that bidirectional Eph/Ephrin signalling is mediated by signalling filopodia and can occur at a distance. Further to this, Eph/Ephrin signalling between liver precursors and the adjacent mesoderm is key for the asymmetric placement of the liver and for the correct formation of the ducts connecting the liver and the pancreas to the gut.

In 2013, I moved to Dr David Wilkinson laboratory (The Francis Crick Institute, London) where I investigated the role of Eph/Ephrin signalling in the formation of tissue boundaries, a critical process in embryonic development and disease. For this, I established knock-out and knock-in CRISPR/Cas9 strategies and generated null and signalling-deficient Eph/Ephrin zebrafish lines. Using these tools, I discovered that the Eph receptor coordinates the formation of sharp borders with the acquisition of cell identities by regulating the mechanical properties of cells and activating the transcription factors Yap/Taz.

I was also a Teaching Assistant at the prestigious “Embryology: Concepts & Techniques in Modern Developmental Biology” course at the Marine Biology Laboratories (Woods Hole, University of Chicago, US) and since 2023 I am a group leader and Senior Lecturer in Biomedical Sciences at the University of Portsmouth.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 4 - Quality Education
  • SDG 10 - Reduced Inequalities

Education/Academic qualification

PG Cert, Higher Education and Professional Practice, University of Wolverhampton

10 Jan 202114 Jan 2022

Award Date: 14 Jan 2022

Ph.D., New roles of the Shh pathway in the development of the vertebrate caudal neural tube, University of Barcelona

1 Apr 200220 Jul 2006

Award Date: 20 Jul 2006

MRes, Role of glaikit in the development of the nervous system in Drosophila, University of Barcelona

15 Sept 200021 Mar 2002

Award Date: 21 Mar 2002

BSc, Biology, University of Barcelona

10 Sept 199631 Jul 2000

Award Date: 31 Jul 2000

External positions

Group Leader & Senior Lecturer, University of Wolverhampton

1 Dec 202024 Mar 2023

Visiting Scientist, The Francis Crick Institute

1 Jan 202031 Dec 2023

Senior Laboratory Research Scientist, The Francis Crick Institute

1 Mar 201631 Dec 2019

Teaching Assistant, Marine Biological Laboratory

15 Jun 201210 Jul 2016


  • QH301 Biology
  • Cell biology
  • Development
  • Signalling
  • Eph/Ephrin
  • Mechanotransduction
  • Zebrafish
  • Regeneration
  • Neurobiology
  • Neurodegeneration
  • QH426 Genetics
  • Gene Editing
  • Animal Models