Jordi Cayuso Mas

Accepting PhD Students

PhD projects

- Role of Eph/Ephrin Signalling in Neural Regeneration
- Molecular Mechanisms of Fin Regeneration in Zebrafish
- Cell Signalling during Neural Tube Closure
- Eph/Ephrin Signalling and Neurodegeneration

Personal profile

Biography

After obtaining a degree in Biology and an MRes at the University of Barcelona, Jordi Cayuso completed his PhD with Dr Elisa Marti at the Molecular Biology Institute of Barcelona. There, he uncovered how Sonic Hedgehog coordinates the patterning, growth, and differentiation of neural precursors in the vertebrate neural tube.

He then moved to the UK for his first postdoctoral position with Dr Elke Ober at the MRC National Institute for Medical Research in London. During this time, he began studying the Eph/Ephrin signalling pathway. His findings revealed that Eph/Ephrin signalling between liver precursors and the adjacent mesoderm is crucial for the asymmetric placement of the liver and the proper formation of the ducts connecting the liver and the pancreas to the gut.

In 2013, he joined Dr David Wilkinson's laboratory at The Francis Crick Institute in London, where he discovered that the Eph receptor coordinates the formation of sharp borders with the acquisition of cell identities by regulating the mechanical properties of cells and activating the transcription cofactors Yap/Taz.

In 2023, Jordi Cayuso joined the University of Portsmouth as a Group Leader and Senior Lecturer in Biomedical Sciences. Currently, he is investigating how Eph/Ephrin signalling is involved in various aspects of neural development, tissue regeneration, and neurodegeneration.

In addition to his research, he has contributed as a Teaching Assistant at the prestigious “Embryology: Concepts & Techniques in Modern Developmental Biology” course at the Marine Biological Laboratory (Woods Hole, University of Chicago, US).

Alongside research, I contributed as a Teaching Assistant at the prestigious “Embryology: Concepts & Techniques in Modern Developmental Biology” course at the Marine Biology Laboratories (Woods Hole, University of Chicago, US).

Research Interests

Our research aims to uncover the cellular and molecular mechanisms controlling:

- Neural tube development.

- Neural regeneration.

- Neurodegenerative diseases and genetic conditions affecting brain development.

For this, we use primarily zebrafish models, together with a range of experimental techniques including: CRISPR genome editing, live imaging, image analysis, cell transplantation, transcriptomics, proteomics and behavioural analysis.

 

PhD and MRes opportunities

We are currently accepting applications from MRes and self-funded PhDs. Please email your expression of interest to jordi.cayuso@port.ac.uk.

Further information on current projects can be found here: https://www.port.ac.uk/study/courses/postgraduate-research/pgr-pharmacy-pharmacology-and-biomedical-sciences

 

 

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 4 - Quality Education
  • SDG 10 - Reduced Inequalities
  • SDG 14 - Life Below Water

Education/Academic qualification

PG Cert, Higher Education and Professional Practice, University of Wolverhampton

10 Jan 202114 Jan 2022

Award Date: 14 Jan 2022

Ph.D., New roles of the Shh pathway in the development of the vertebrate caudal neural tube, University of Barcelona

1 Apr 200220 Jul 2006

Award Date: 20 Jul 2006

MRes, Role of glaikit in the development of the nervous system in Drosophila, University of Barcelona

15 Sept 200021 Mar 2002

Award Date: 21 Mar 2002

BSc, Biology, University of Barcelona

10 Sept 199631 Jul 2000

Award Date: 31 Jul 2000

External positions

Group Leader & Senior Lecturer, University of Wolverhampton

1 Dec 202024 Mar 2023

Visiting Scientist, The Francis Crick Institute

1 Jan 202031 Dec 2023

Senior Laboratory Research Scientist, The Francis Crick Institute

1 Mar 201631 Dec 2019

Teaching Assistant, Marine Biological Laboratory

15 Jun 201210 Jul 2016

Keywords

  • QH301 Biology
  • Cell biology
  • Development
  • Signalling
  • Eph/Ephrin
  • Mechanotransduction
  • Zebrafish
  • Regeneration
  • Neurobiology
  • Neurodegeneration
  • QH426 Genetics
  • Gene Editing
  • CRISPR
  • Animal Models