Matt Guille

Matt Guille

Professor

 https://orcid.org/0000-0001-6865-4519

Accepting PhD Students

Personal profile

Biography

I did my degree and PhD in Biochemistry at King’s College London, where I first worked on Xenopus. I went on to post-doc fellowships working on gene regulation at CRUK and the Developmental Biology Research Centre, both in London. From there I moved to Portsmouth setting up an independent lab working on gene regulation in Xenopus and in 2006 led the inception of the European Xenopus Resource Centre funded by the Wellcome Trust. Having Portsmouth as a hub for the latest developmental biology research makes it a very exciting place for me to study and, after doing my five year turn as head of school, I am currently enjoying working hands on alongside my team in the lab.

Alongside my Xenopus work I enjoy collaborating with the Marine Biologists in Portsmouth to support their use of the latest molecular genetics technologies in fascinating applied research projects.

For more information about my research please visit my lab page.

Research Interests

My team researches gene regulation in the early development of the Xenopus (clawed frog) embryo. This includes transcription factor regulation (Brzostowski et al, 2000, Cazanove et al 2008) and epigenetic mechanisms (Steer et al 2003, Abu-Daya et al, 2005). Currently we are performing a systematic analysis of the function and control of the variant histones in early development in collaboration with Dr Fiona Myers. Half of MJG’s time is dedicated to running the European Xenopus Resource Centre (EXRC), in this context developing improved techniques for working with Xenopus (Love et al 2012) and enhancing frog welfare (Abu-Daya et al 2012).

  • Transcription factor activity control in the early embryo
  • dsRBD containing proteins
  • Chromatin regulation in the early embryo
  • The genetics of wood digestion in the marine environment
  • Developing new tools for the Xenopus model

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Collaborations and top research areas from the last five years

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  • 51 Article
  • 3 Other contribution
  • 2 Chapter (peer-reviewed)

  • Monoallelic de novo variants in DDX17 cause a neurodevelopmental disorder

    Seaby, E. G., Godwin, A., Meyer-Dilhet, G., Clerc, V., Grand, X., Fletcher, T., Monteiro, L., Kerkhofs, M., Carelli, V., Palombo, F., Seri, M., Olivucci, G., Grippa, M., Ciaccio, C., D’Arrigo, S., Iascone, M., Bermudez, M., Fischer, J., Di Donato, N. & Goesswein, S. & 25 others, Leung, M. L., Koboldt, D. C., Myers, C., Arnadottir, G. A., Stefansson, K., Sulem, P., Goldberg, E. M., Bruel, A.-L., Tran Mau Them, F., Willems, M., Bjornsson, H. T., Hognason, H. B., Thorolfsdottir, E. T., Agolini, E., Novelli, A., Zampino, G., Onesimo, R., Lachlan, K., Baralle, D., Rehm, H. L., O’Donnell-Luria, A., Courchet, J., Guille, M., Bourgeois, C. F. & Ennis, S., 6 Feb 2025, (Early online) In: Brain. 14 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
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    36 Downloads (Pure)

  • Novel mutations in the RECQL4 gene affect its helicase functions, interactions with the BLM helicase and chemotherapeutics-induced cell death

    Kaczmarczyk, A., Sokolowski, M., Wojnicki, K., Pabis, M., Wojtas, B., Ciechomska, I. A., Poleszak, K., Gielniewski, B., Król, S. K., Guille, M., Glatt, S. & Kaminska, B., 19 Dec 2025, In: Cell Death Discovery. 11, 1, 12 p., 560.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File

  • Shared and non-overlapping functions of RECQL4 and BLM helicases in chemotherapeutics-induced glioma cell responses

    Wojnicki, K., Wojtas, B., Ciechomska, I. A., Kaza, B., Guille, M., Priebe, W. & Kaminska, B., 29 Sept 2025, In: BMC Cancer. 25, 1, 10 p., 1434.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File
    6 Downloads (Pure)

  • Bi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive and complex movement disorders

    Kaiyrzhanov, R., Rad, A., Lin, S.-J., Bertoli-Avella, A., Kallemeijn, W. W., Godwin, A., Zaki, M. S., Huang, K., Lau, T., Petree, C., Efthymiou, S., Karimiani, E. G., Hempel, M., Normand, E. A., Rudnik-Schöneborn, S., Schatz, U. A., Baggelaar, M. P., Ilyas, M., Sultan, T. & Alvi, J. R. & 69 others, Ganieva, M., Fowler, B., Aanicai, R., Tayfun, G. A., Al saman, A., Alswaid, A., Amiri, N., Asilova, N., Shotelersuk, V., Yeetong, P., Azam, M., Babaei, M., Monajemi, G. B., Mohammadi, P., Samie, S., Banu, S. H., Basto, J. P., Kortüm, F., Bauer, M., Bauer, P., Beetz, C., Garshasbi, M., Issa, A. H., Eyaid, W., Ahmed, H., Hashemi, N., Hassanpour, K., Herman, I., Ibrohimov, S., Abdul-Majeed, B. A., Imdad, M., Isrofilov, M., Kaiyal, Q., Khan, S., Kirmse, B., Koster, J., Marques Lourenço, C., Mitani, T., Moldovan, O., Murphy, D., Najafi, M., Pehlivan, D., Rocha, M. E., Salpietro, V., Schmidts, M., Shalata, A., Mahroum, M., Talbeya, J. K., Taylor, R. W., Vazquez, D., Vetro, A., Waterham, H. R., Zaman, M., Schrader, T. A., Chung, W. K., Guerrini, R., Lupski, J. R., Gleeson, J., Suri, M., Jamshidi, Y., Bhatia, K. P., Vona, B., Severino, M., Schrader, M., Guille, M., Tate, E. W., Varshney, G. K., Houlden, H. & Maroofian, R., 1 Apr 2024, In: Brain. 147, 4, p. 1436–1456

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File
    79 Downloads (Pure)

  • Modelling human genetic disorders in Xenopus tropicalis

    Willsey, H. R., Seaby, E. G., Godwin, A., Ennis, S., Guille, M. & Grainger, R. M., 4 Jun 2024, In: Disease Models & Mechanisms. 17, 5, p. 1-12 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
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    121 Downloads (Pure)
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