Roger Draheim

2022

Antimicrobial compounds from an FDA‐approved drug library with activity against Streptococcus suis

Li, H., Li, T., Zhang, L., Hu, Q., Liao, X., Jiang, Q., Qiu, X., Li, L., Draheim, R. R., Huang, Q. & Zhou, R., 1 Mar 2022, In: Journal of Applied Microbiology. 132, 3, p. 1877-1886 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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8 Downloads (Pure)

Enhancing the antibacterial effect of Chitosan to combat orthopaedic implant-associated infections

Rahayu, D. P., De Mori, A., Yusuf, R., Draheim, R., Lalatsa, A. & Roldo, M., 1 Aug 2022, In: Carbohydrate Polymers. 289, 119385.

Research output: Contribution to journal › Article › peer-review

Open Access

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3 Downloads (Pure)

Harnessing the properties of fluoridated chitosan polymers against the formation of oral biofilms

Rahayu, D. P., De Mori, A., Draheim, R., Lalatsa, K. & Roldo, M., 23 Feb 2022, In: Pharmaceutics. 14, 3, 15 p., 488.

Research output: Contribution to journal › Article › peer-review

Open Access

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39 Downloads (Pure)

2021

Comparative phenotypic, proteomic, and phosphoproteomic analysis reveals different roles of serine/threonine phosphatase and kinase in the growth, cell division, and pathogenicity of Streptococcus suis

Hu, Q., Yao, L., Liao, X., Zhang, L-S., Li, H-T., Li, T-T., Jiang, Q-G., Tan, M-F., Li, L., Draheim, R., Huang, Q. & Zhou, R., 26 Nov 2021, In: Microorganisms. 9, 12, 21 p., 2442.

Research output: Contribution to journal › Article › peer-review

Open Access

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11 Downloads (Pure)

2020

Evaluation of antibacterial and cytotoxicity properties of silver nanowires and their composites with carbon nanotubes for biomedical applications

De Mori, A., Jones, R. S., Cretella, M., Cerri, G., Draheim, R., Barbu, E., Tozzi, G. & Roldo, M., 26 Mar 2020, In: International Journal of Molecular Sciences. 21, 7, 22 p., 2303.

Research output: Contribution to journal › Article › peer-review

Open Access

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102 Downloads (Pure)

2019

Antibacterial PMMA composite cements with tunable thermal and mechanical properties

De Mori, A., Di Gregorio, E., Kao, A., Tozzi, G., Barbu, E., Sanghani-Kerai, A., Draheim, R. & Roldo, M., 14 Nov 2019, In: ACS Omega. 4, 22, p. 19664-19675 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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142 Downloads (Pure)

Sustained release from injectable composite gels loaded with silver nanowires designed to combat bacterial resistance in bone regeneration applications

De Mori, A., Hafidh, M., Mele, N., Yusuf, R., Cerri, G., Gavini, E., Tozzi, G., Barbu, E., Conconi, M. T., Draheim, R. & Roldo, M., 12 Mar 2019, In: Pharmaceutics. 11, 3, 116.

Research output: Contribution to journal › Article › peer-review

Open Access

File

270 Downloads (Pure)

2018

Silver nanowires: synthesis, antibacterial activity and biomedical applications

Jones, R. S., Draheim, R. & Roldo, M., 26 Apr 2018, In: Applied Sciences. 8, 5, 673.

Research output: Contribution to journal › Article › peer-review

Open Access

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460 Downloads (Pure)

Tuning chemoreceptor signaling by positioning aromatic residues at the lipid-aqueous interface

Yusuf, R., Lawrence, R., Eke, L. & Draheim, R., 11 Feb 2018, (Early online) Bacterial Chemosensing. Springer, Vol. 1729. (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

Open Access

2017

A modular high-throughput in vivo screening platform based upon chimeric bacterial receptors

Lehning, C., Heidelberger, J., Reinhard, J., Nørholm, M. H. H. & Draheim, R., 21 Jul 2017, In: ACS Synthetic Biology. 6, 7, p. 1315-1326 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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234 Downloads (Pure)

2016

High-throughput discovery of novel antibiotics

Taqi, A. & Draheim, R., 15 Oct 2016.

Research output: Contribution to conference › Poster › peer-review

Identification of transmembrane helix 1 (TM1) surfaces important for EnvZ dimerisation and signal output

Heininger, A., Yusuf, R., Lawrence, R. & Draheim, R. R., 4 May 2016, In: Biochimica et Biophysica Acta (BBA) - Biomembranes.

Research output: Contribution to journal › Article › peer-review

Open Access

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343 Downloads (Pure)

Screening for compounds that bind to the histidine kinase WalK from Staphylococcus aureus

Taqi, A. & Draheim, R., 14 Nov 2016.

Research output: Contribution to conference › Poster › peer-review

2015

Differential repositioning of the second transmembrane helices from E. coli Tar and EnvZ upon moving the flanking aromatic residues

Botelho, S. C., Enquist, K., Von Heijne, G. & Draheim, R. R., 1 Feb 2015, In: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1848, 2, p. 615-621 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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144 Downloads (Pure)

Employing aromatic tuning to modulate output from two-component signaling circuits

Yusuf, R. & Draheim, R. R., 1 Dec 2015, In: Journal of Biological Engineering. 9, 1, p. 7 7.

Research output: Contribution to journal › Article › peer-review

Open Access

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111 Downloads (Pure)

Employing aromatic tuning to modulate signal output from two-component signalling circuits

Lehning, C., Heidelberger, J., Reinhard, J. & Draheim, R. R., 2015.

Research output: Contribution to conference › Poster › peer-review

Forcing the issue: aromatic tuning facilitates stimulus- independent modulation of a two-component signaling circuit

Nørholm, M. H. H., von Heijne, G. & Draheim, R. R., 17 Apr 2015, In: ACS Synthetic Biology. 4, 4, p. 474-481 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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118 Downloads (Pure)

Synthetic approaches to targeting bacterial signalling processes

Draheim, R. R., 2015.

Research output: Contribution to conference › Paper › peer-review

Synthetic targeting of two-component signalling circuits

Draheim, R. R., Jun 2015.

Research output: Contribution to conference › Paper › peer-review

2013

Residues at the cytoplasmic end of transmembrane helix 2 determine the signal output of the Tar_Ec chemoreceptor

Adase, C. A., Draheim, R. R., Rueda, G., Desai, R. & Manson, M. D., 23 Apr 2013, In: Biochemistry. 52, 16, p. 2729-2738

Research output: Contribution to journal › Article › peer-review

'Written Evidence' concerning 'UK Five Year Antimicrobial Resistance Strategy 2013-2018' to the Select Committee on Science and Technology, House of Commons, UK Parliament

Draheim, R. R., Oct 2013, London: Houses of Parliament.

Research output: Working paper › Discussion paper

2012

The residue composition of the aromatic anchor of the second transmembrane helix determines the signaling properties of the aspartate/maltose chemoreceptor Tar of Escherichia coli

Adase, C. A., Draheim, R. R. & Manson, M. D., 6 Mar 2012, In: Biochemistry. 51, 9, p. 1925-1932

Research output: Contribution to journal › Article › peer-review

2011

HAMP-membrane interactions correlate with the signaling mechanism and sub-celleular location of HAMP-containing receptors

Unnerståle, S., Mäler, L. & Draheim, R. R., Sept 2011.

Research output: Contribution to conference › Poster › peer-review

In vivo reconstitution of the EnvZ-OmpR osmosensing circuit suggests a non-piston mechanism of transmembrane communication

Draheim, R. R., Jan 2011.

Research output: Contribution to conference › Poster › peer-review

Mutational analysis of the transmembrane helix 2-HAMP domain connection in the Escherichia coli aspartate chemoreceptor Tar

Wright, G. A., Crowder, R. L., Draheim, R. R. & Manson, M. D., 1 Jan 2011, In: Journal of Bacteriology. 193, 1, p. 82-90

Research output: Contribution to journal › Article › peer-review

Structural characterization of AS1–membrane interactions from a subset of HAMP domains

Unnerståle, S., Mäler, L. & Draheim, R. R., Oct 2011, In: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1808, 10, p. 2403-2412

Research output: Contribution to journal › Article › peer-review

2010

Toward rational engineering of two-component signal output

Draheim, R. R. & Von Heijne, G., May 2010.

Research output: Contribution to conference › Poster › peer-review

2009

A rotational model for EnvZ signal transduction

Draheim, R. R., Nørholm, M. H. H., Botelho, S. C., Enquist, K. & Von Heijne, G., Jan 2009.

Research output: Contribution to conference › Poster › peer-review

2008

The region preceding the C-Terminal NWETF pentapeptide modulates baseline activity and aspartate inhibition of Escherichia coli Tar

Lai, R-Z., Bormans, A. F., Draheim, R. R., Wright, G. A. & Manson, M. D., 16 Dec 2008, In: Biochemistry. 47, 50, p. 13287-13295

Research output: Contribution to journal › Article › peer-review

Tuning Escherichia coli for membrane protein overexpression

Wagner, S., Klepsch, M. M., Schlegel, S., Appel, A., Draheim, R., Tarry, M., Hogbom, M., Van Wijk, K. J., Slotboom, D. J., Persson, J. O. & De Gier, J. W., 23 Sept 2008, In: Proceedings of the National Academy of Sciences. 105, 38, p. 14371-14376

Research output: Contribution to journal › Article › peer-review

2007

Tuning a bacterial chemoreceptor with membrane-protein interactions

Draheim, R. R., Bormans, A. F., Lai, R. & Manson, M. D., Jan 2007.

Research output: Contribution to conference › Poster › peer-review

Tuning signal output with receptor-membrane interactions

Draheim, R. R., Aug 2007.

Research output: Contribution to conference › Poster › peer-review

2006

2005

2004

Tryptophan residues flanking the second transmembrane helix (TM2) set the signaling state of Tar

Draheim, R. R., Bormans, A. F., Lai, R-Z. & Manson, M. D., 2004.

Research output: Contribution to conference › Paper › peer-review

Tuning receptor output with protein-membrane interactions

Draheim, R. R., Bormans, A. F., Lai, R. & Manson, M. D., 2004.

Research output: Contribution to conference › Paper › peer-review

2003

CheZ phosphatase localizes to chemoreceptor patches via CheA-short

Cantwell, B. J., Draheim, R. R., Weart, R. B., Nguyen, C., Stewart, R. C. & Manson, M. D., Apr 2003, In: Journal of Bacteriology. 185, 7, p. 2354-2361

Research output: Contribution to journal › Article › peer-review

Tryptophan residues flanking the second transmembrane helix (TM2) set the signaling state of Tar

Draheim, R. R., Bormans, A. F., Lai, R-Z. & Manson, M. D., Jan 2003.

Research output: Contribution to conference › Poster › peer-review

2002

In vivo MBP-Tar crosslinking suggests an asymmetrical signaling mechanism

Zhang, Y., Draheim, R. R. & Manson, M. D., 2002.

Research output: Contribution to conference › Poster › peer-review

2001

In vivo MBP-Tar crosslinking suggests an asymmetrical signaling mechanism

Zhang, Y., Draheim, R. R. & Manson, M. D., Jan 2001.

Research output: Contribution to conference › Poster › peer-review

Roger Draheim

Research output

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