Research outputs per year
Research outputs per year
Personal profile
Biography
I have a BSc in Biochemistry from Royal Holloway and Bedford New College, University of London. I have a PhD in cardiovascular cell pharmacology from the National Heart and Lung Institute, Imperial College London, under the supervision of Prof Sir Magdi Yacoub.
I was an EU Marie Curie Postdoctoral Fellow at Lund University, Sweden, working with Prof. Björn Dahlbäck on the cellular biology of the Gas6-TAM signalling system. I continued my research work under higher postdoctoral fellowships and then as an independent investigator, until I joined the University of Portsmouth in 2009 as Senior Lecturer. I was promoted to Reader in Cell and Molecular Biology in September 2017.
For more information about my research please visit my lab page
Research Interests
1) Gas6-TAM ligand-receptor signalling and its role in normal and pathophysiological cell biology, including cancer and neurological diseases.
2) Intracellular signalling via the Tensin family proteins in normal and cancer cell biology.
Full-time project supervision: PhD studentship projects, ERASMUS internship students, Brazilian undergraduate “Science without Borders” placements; undergraduate summer bursary students.
Leader of Cellular Signalling Group.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- Q Science (General)
- Cell biology
- Molecular biology
- RS Pharmacy and materia medica
- Pharmacology
- Small molecule inhibitors
- RB Pathology
- Cancer
- multiple sclerosis
- Inflammation
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The first laminin G-like domain of protein S is essential for binding and activation of Tyro3 receptor and intracellular signalling
Al Kafri, N., Ahnström, J., Teraz-Orosz, A., Chaput, L., Singh, N., Villoutreix, B. O. & Hafizi, S., 1 Jul 2022, In: Biochemistry and Biophysics Reports. 30, 11 p., 101263.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
Transient regulation of focal adhesion via Tensin3 is required for nascent oligodendrocyte differentiation
Merour, E., Hmidan, H., Marie, C., Helou, P-H., Lu, H., Potel, A., Hure, J-B., Clavairoly, A., Shih, Y. P., Goudarzi, S., Dussaud, S., Ravassard, P., Hafizi, S., Lo, S. H., Hassan, B. A. & Parras, C., 10 Oct 2022, In: eLife. 11, 34 p., e80273.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
Functional succinate dehydrogenase deficiency is a common adverse feature of clear cell renal cancer
Aggarwal, R. K., Luchtel, R. A., Machha, V., Tischer, A., Zou, Y., Pradhan, K., Ashai, N., Ramachandra, N., Albanese, J. M., Yang, J., Wang, X., Aluri, S., Gordon, S., Aboumohamed, A., Gartrell, B. A., Hafizi, S., Pullman, J. & Shenoy, N., 28 Sep 2021, In: Proceedings of the National Academy of Sciences. 118, 39, 12 p., e2106947118.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Downloads (Pure) -
Gas6/TAM signalling negatively regulates inflammatory induction of GM-CSF in mouse brain microglia
Gilchrist, S. E., Pennelli, G. M. & Hafizi, S., 24 Nov 2021, In: Cells. 10, 12, 14 p., 3281.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Downloads (Pure) -
Identification of signalling pathways activated by Tyro3 that promote cell survival, proliferation and invasiveness in human cancer cells
Al Kafri, N. & Hafizi, S., 1 Dec 2021, In: Biochemistry and Biophysics Reports. 28, 10 p., 101111.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Downloads (Pure)
Press / Media
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Funding awarded for multiple sclerosis research
13/10/16
1 item of Media coverage
Press/Media: Research cited
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MS Society Research Matters - Researcher Perspective
5/05/15
1 item of Media coverage
Press/Media: Research cited