Sassan Hafizi

2023

The molecular and clinical role of Tensin 1/2/3 in cancer

Mainsiouw, L., Ryan, M., Hafizi, S. & Fleming, J. C., 9 Jun 2023, (Early online) In: Journal of Cellular and Molecular Medicine.

Research output: Contribution to journal › Literature review › peer-review

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2022

The first laminin G-like domain of protein S is essential for binding and activation of Tyro3 receptor and intracellular signalling

Al Kafri, N., Ahnström, J., Teraz-Orosz, A., Chaput, L., Singh, N., Villoutreix, B. O. & Hafizi, S., 1 Jul 2022, In: Biochemistry and Biophysics Reports. 30, 11 p., 101263.

Research output: Contribution to journal › Article › peer-review

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Transient regulation of focal adhesion via Tensin3 is required for nascent oligodendrocyte differentiation

Merour, E., Hmidan, H., Marie, C., Helou, P-H., Lu, H., Potel, A., Hure, J-B., Clavairoly, A., Shih, Y. P., Goudarzi, S., Dussaud, S., Ravassard, P., Hafizi, S., Lo, S. H., Hassan, B. A. & Parras, C., 10 Oct 2022, In: eLife. 11, 34 p., e80273.

Research output: Contribution to journal › Article › peer-review

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2021

Functional succinate dehydrogenase deficiency is a common adverse feature of clear cell renal cancer

Aggarwal, R. K., Luchtel, R. A., Machha, V., Tischer, A., Zou, Y., Pradhan, K., Ashai, N., Ramachandra, N., Albanese, J. M., Yang, J., Wang, X., Aluri, S., Gordon, S., Aboumohamed, A., Gartrell, B. A., Hafizi, S., Pullman, J. & Shenoy, N., 28 Sept 2021, In: Proceedings of the National Academy of Sciences. 118, 39, 12 p., e2106947118.

Research output: Contribution to journal › Article › peer-review

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Gas6/TAM signalling negatively regulates inflammatory induction of GM-CSF in mouse brain microglia

Gilchrist, S. E., Pennelli, G. M. & Hafizi, S., 24 Nov 2021, In: Cells. 10, 12, 14 p., 3281.

Research output: Contribution to journal › Article › peer-review

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Identification of signalling pathways activated by Tyro3 that promote cell survival, proliferation and invasiveness in human cancer cells

Al Kafri, N. & Hafizi, S., 1 Dec 2021, In: Biochemistry and Biophysics Reports. 28, 10 p., 101111.

Research output: Contribution to journal › Article › peer-review

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Immune evasion in renal cell carcinoma: biology, clinical translation, future directions

Wang, X., Lopez, R., Luchtel, R., Hafizi, S., Gartrell, B. & Shenoy, N. K., 1 Jan 2021, In: Kidney International. 99, 1, p. 75-85 11 p.

Research output: Contribution to journal › Literature review › peer-review

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Inhibition of DCLK1 with DCLK1-in-1 suppresses renal cell carcinoma invasion and stemness and promotes cytotoxic T-cell-mediated anti-tumor immunity

Ding, L., Yang, Y., Ge, Y., Lu, Q., Yan, Z., Chen, X., Du, J., Hafizi, S., Xu, X., Yao, J., Liu, J., Cao, Z. & Weygant, N., 16 Nov 2021, In: Cancers. 13, 22, 19 p., 5729.

Research output: Contribution to journal › Article › peer-review

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2020

A supervisor's story: Portsmouth

Hafizi, S., 7 Oct 2020, CARA Annual Report 2019-2020. Council for At-Risk Academics, p. 19 1 p. (CARA Annual Report 2019-2020).

Research output: Chapter in Book/Report/Conference proceeding › Other chapter contribution

Open Access

CTEN induces tumour cell invasion and survival and is prognostic in radiotherapy-treated head and neck cancer

Fleming, J. C., Woo, J., Moutasim, K., Hanley, C. J., Frampton, S. J., Wood, O., Ward, M., Woelk, C. H., Ottensmeier, C. H., Hafizi, S., Kim, D. & Thomas, G. J., 13 Oct 2020, In: Cancers. 12, 10, 21 p., 2963.

Research output: Contribution to journal › Article › peer-review

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Galectin-3 stimulates Tyro3 receptor tyrosine kinase and Erk signalling, cell survival and migration in human cancer cells

Al Abdullah Al Kafri, N. & Hafizi, S., 11 Jul 2020, In: Biomolecules. 10, 7, 15 p., 1035.

Research output: Contribution to journal › Article › peer-review

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Gas6 induces myelination through anti-inflammatory IL-10 and TGF-β upregulation in white matter and glia

Goudarzi, S., Gilchrist, S. E. & Hafizi, S., 26 Jul 2020, In: Cells. 9, 8, 1779.

Research output: Contribution to journal › Article › peer-review

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Gas6 inhibits toll-like receptor-mediated inflammatory pathways in mouse microglia via Axl and Mer

Gilchrist, S. E., Goudarzi, S. & Hafizi, S., 9 Oct 2020, In: Frontiers in Cellular Neuroscience. 14, 10 p., 576650.

Research output: Contribution to journal › Article › peer-review

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2019

Tumour-secreted protein S (ProS1) activates a Tyro3-Erk signalling axis and protects cancer cells from apoptosis

Al Abdullah Al Kafri, N. & Hafizi, S., 22 Nov 2019, In: Cancers. 11, 12, 17 p., 1843.

Research output: Contribution to journal › Article › peer-review

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2017

TAM receptor tyrosine kinases in cancer drug resistance

Vouri, M. & Hafizi, S., 19 May 2017, (Early online) In: Cancer Research.

Research output: Contribution to journal › Article › peer-review

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2016

Axl-EGFR receptor tyrosine kinase hetero-interaction provides EGFR with access to pro-invasive signalling in cancer cells

Vouri, M., Croucher, D. R., Kennedy, S. P., An, Q., Pilkington, G. J. & Hafizi, S., 24 Oct 2016, In: Oncogenesis. 5, 10, e266.

Research output: Contribution to journal › Article › peer-review

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Dysregulated expression of Tensin2 and components of the PI3 Kinase/Akt signaling pathway in human thyroid carcinoma

Erfani, N., Fattahi, M. J., Dabbaghmanesh, M. H., Mehr, M., Monabati, A., Hafizi, S. & Ghaderi, A., 1 Jan 2016, In: Middle East Journal of Cancer. 7, 1, 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Dysregulated expression of Tensin 2 and components of the PI3 Kinase/Akt signaling pathway in human thyroid carcinoma

Erfani, N., Fattahi, M. J., Dabbaghmanesh, M. H., Mehrazmay, M., Monabati, A., Kazerouni, A. R., Hafizi, S. & Ghaderi, A., 1 Jan 2016, In: Middle East Journal of Cancer. 7, 1, p. 1-7 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Gas6 promotes oligodendrogenesis and myelination in the adult central nervous system and after lysolecithin-induced demyelination

Goudarzi, S., Rivera, A., Butt, A. M. & Hafizi, S., Sept 2016, In: ASN Neuro. 8, 5, p. 1-14

Research output: Contribution to journal › Article › peer-review

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Lycopene acts through inhibition of IκB kinase to suppress NF-κB signaling in human prostate and breast cancer cells

Assar, E. A., Vidalle, M. C., Chopra, M. & Hafizi, S., Jul 2016, In: Tumor Biology. 37, 7, p. 9375-9385

Research output: Contribution to journal › Article › peer-review

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2015

Hollow-layered nanoparticles for therapeutic delivery of peptide prepared using electrospraying

Rasekh, M., Young, C., Roldo, M., Lancien, F., Le Mével, J-C., Hafizi, S., Ahmad, Z., Barbu, E. & Gorecki, D., 1 Nov 2015, In: Journal of Materials Science: Materials in Medicine. 26, 11

Research output: Contribution to journal › Article › peer-review

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Small molecule inhibition of Axl receptor tyrosine kinase potently suppresses multiple malignant properties of glioma cells

Vouri, M., An, Q., Birt, M., Pilkington, G. J. & Hafizi, S., 29 Apr 2015, In: Oncotarget. p. 1-15

Research output: Contribution to journal › Article › peer-review

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2014

Axl/Gas6/NFκB signalling in schwannoma pathological proliferation, adhesion and survival

Ammoun, S., Provenzano, L., Zhou, L., Barczyk, M., Evans, K., Hilton, D., Hafizi, S. & Hanemann, C., 16 Jan 2014, In: Oncogene. 33, p. 336-346

Research output: Contribution to journal › Article › peer-review

Open Access

Receptor tyrosine kinases — expanding horizons

Hafizi, S., 20 Jun 2014, In: Cells. 3, 2, p. 657-659 3 p.

Research output: Contribution to journal › Editorial › peer-review

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2013

CpG dinucleotide-specific hypermethylation of the TNS3 gene promoter in human renal cell carcinoma

Carter, J., Gorecki, D., Mein, C., Ljungberg, B. & Hafizi, S., Jul 2013, In: Epigenetics. 8, 7, p. 739-747 9 p.

Research output: Contribution to journal › Article › peer-review

Erratum: Identification of candidate genes encoding an LDL-C QTL in baboons (Journal of Lipid Research (2013) 54:7 (1776-1785))

Karere, G. M., Glenn, J. P., Birnbaum, S., Hafizi, S., Rainwater, D. L., Mahaney, M. C., VandeBerg, J. L. & Cox, L. A., 1 Aug 2013, In: Journal of Lipid Research. 54, 8, 1 p.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

Functional characterisation of human cells harbouring a novel t(2p;7p) translocation involving TNS3 and EXOC6B genes

Ludwig, D., Carter, J., Smith, J. R., Borsani, G., Barlati, S. & Hafizi, S., Jun 2013, In: BMC Medical Genetics. 14, p. 65 1 p.

Research output: Contribution to journal › Article › peer-review

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Identification of candidate genes encoding an LDL-C QTL in baboons

Karere, G., Glenn, J. P., Birnbaum, S., Hafizi, S., Rainwater, D., Mahaney, M., VandeBerg, J. & Cox, L., Jul 2013, In: Journal of Lipid Research. 54, 7, p. 1776-1785 10 p.

Research output: Contribution to journal › Article › peer-review

Interaction of DISC1 with the PTB domain of Tensin2

Goudarzi, S., Smith, L., Schutz, S. & Hafizi, S., May 2013, In: Cellular and Molecular Life Sciences (CMLS). 70, 9, p. 1663-1672 10 p.

Research output: Contribution to journal › Article › peer-review

2012

Individual domains of Tensin2 exhibit distinct subcellular localisations and migratory effects

Hafizi, S., Sernstad, E., Swinny, J., Gomez, M. & Dahlback, B., 2010, In: The International Journal of Biochemistry & Cell Biology. 42, 1, p. 52-61 10 p.

Research output: Contribution to journal › Article › peer-review

Role of the GAS6-AXL receptor-ligand pairing in migration of human glioma cells

Smith, J., Pilkington, G. & Hafizi, S., 2010, In: Neuro-Oncology. 12, Supp 1, p. i9

Research output: Contribution to journal › Article › peer-review

Tensin2 reduces intracellular phosphatidylinositol 3,4,5-trisphosphate levels at the plasma membrane

Hafizi, S., Gustafsson, A., Oslakovic, C., Idevall-Hagren, O., Tengholm, A., Sperandio, O., Villoutreix, B. & Dahlback, B., 2010, In: Biochemical and Biophysical Research Communications. 399, 3, p. 396-401 6 p.

Research output: Contribution to journal › Article › peer-review

2009

Differential expression of Axl and Gas6 in renal cell carcinoma reflecting tumor advancement and survival

Gustafsson, A., Martuszewska, D., Johansson, M., Ekman, C., Hafizi, S., Ljungberg, B. & Dahlback, B., 2009, In: Clinical Cancer Research. 15, 14, p. 4742-4749 8 p.

Research output: Contribution to journal › Article › peer-review

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Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer

Martuszewska, D., Ljungberg, B., Johansson, M., Landberg, G., Oslakovic, C., Dahlback, B. & Hafizi, S., 2009, In: PLoS One. 4, 2, p. e4350

Research output: Contribution to journal › Article › peer-review

2006

Gas6 and protein S: Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily

Hafizi, S. & Dahlback, B., Dec 2006, In: The FEBS Journal. 273, 23, p. 5231-5244 14 p.

Research output: Contribution to journal › Article › peer-review

Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases

Hafizi, S. & Dahlback, B., Aug 2006, In: Cytokine & Growth Factor Reviews. 17, 4, p. 295-304 10 p.

Research output: Contribution to journal › Article › peer-review

2005

Analysis of Gas6 in human platelets and plasma

Balogh, I., Hafizi, S., Stenhoff, J., Dahlback, B. & Hansson, K. M., 2005, In: Arteriosclerosis, Thrombosis and Vascular Biology. 25, 6, p. 1280-1286

Research output: Contribution to journal › Article › peer-review

C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration

Hafizi, S., Ibraimi, F. & Dahlback, B., 2005, In: FASEB Journal. 19, 8, p. 971-973 3 p.

Research output: Contribution to journal › Article › peer-review

The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases

Hafizi, S., Gustafsson, A., Stenhoff, J. & Dahlback, B., Nov 2005, In: The International Journal of Biochemistry & Cell Biology. 37, 11, p. 2344-2356 13 p.

Research output: Contribution to journal › Article › peer-review

2004

ANG II activates effectors of mTOR via PI3-K signaling in human coronary smooth muscle cells

Hafizi, S., Wang, X., Chester, A., Yacoub, M. & Proud, C., Sept 2004, In: AJP: Heart and Circulatory Physiology. 287, 3, p. H1232-H1238

Research output: Contribution to journal › Article › peer-review

Differential effects of rapamycin, cyclosporine A, and FK506 on human coronary artery smooth muscle cell proliferation and signalling

Hafizi, S., Mordi, V., Andersson, K., Chester, A. & Yacoub, M., 2004, In: Vascular Pharmacology. 41, 4-5, p. 167-176 10 p.

Research output: Contribution to journal › Article › peer-review

2002

Human vascular smooth muscle cells from restenosis or in-stent stenosis sites demonstrate enhanced responses to p53: implications for brachytherapy and drug treatment for restenosis

Scott, S., O'Sullivan, M., Hafizi, S., Shapiro, L. & Bennett, M., 8 Mar 2002, In: Circulation Research. 90, 4, p. 398-404 7 p.

Research output: Contribution to journal › Article › peer-review

Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin

Hafizi, S., Alindri, F., Karlsson, R. & Dahlback, B., 20 Dec 2002, In: Biochemical and Biophysical Research Communications. 299, 5, p. 793-800 8 p.

Research output: Contribution to journal › Article › peer-review

2000

Mitogenic and secretory responses of human valve interstitial cells to vasoactive agents

Hafizi, S., Taylor, P. M., Chester, A., Allen, S. P. & Yacoub, M., May 2000, In: The Journal of Heart Valve Disease. 9, 3, p. 454-458 5 p.

Research output: Contribution to journal › Article › peer-review

Vascular endothelial growth factor release following coronary artery bypass surgery: extracorporeal circulation versus 'beating heart' surgery

Burton, P. B. J., Owen, V. J., Hafizi, S., Barton, P. J. R., Carr-White, G., Koh, T., De Souza, A., Yacoub, M. H. & Pepper, J. R., Oct 2000, In: European Heart Journal. 21, 20, p. 1708-1713

Research output: Contribution to journal › Article › peer-review

1999

Endothelin-1 stimulates proliferation of human coronary smooth muscle cells via the ET_Areceptor and is co-mitogenic with growth factors

Hafizi, S., Allen, S. P., Goodwin, A. T., Chester, A. H. & Yacoub, M. H., 1 Oct 1999, In: Atherosclerosis. 146, 2, p. 351-359 9 p.

Research output: Contribution to journal › Article › peer-review

Sassan Hafizi

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