Enhancing PMMA Bone Cement Performance and Biocompatibility using Metal-Organic Frameworks

This project aims to enhance the performance of poly(methyl methacrylate) (PMMA) bone cements by incorporating nanosized zeolitic imidazolate framework-8 (ZIF-8), with or without magnesium doping. The study will focus on optimizing the synthesis of ZIF-8, integrating it into PMMA cements, and evaluating its effects on mechanical strength, polymerization temperature, antimicrobial properties, and cytocompatibility. By improving these characteristics, the research seeks to advance bone cements towards better osseointegration, reduced toxicity, and effective drug delivery, potentially leading to significant clinical benefits and advancements in bone repair technologies.