A comparison of the free radical scavenging activity of leukotrienes and prostaglandins

M. Chopra*, J. J. F. Belch, W. E. Smith

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The relative reactivity of leukotrienes and prostaglandins to free radicals and the superoxide ion generated by the photo oxidation of dianisidine have been assessed in vitro. Leukotrienes are effective general radical scavengers rather than superoxide scavengers, with the order of effectiveness LTD, > LTC4 > LTB4. Prostaglandins are relatively unreactive. It is suggested that this susceptibility to free radical attack may be one reason for the formation of chemotactic agents from leukotrienes rather than prostaglandins and this may be one part of the mode of action of these compounds in chronic inflammation.

Original languageEnglish
Pages (from-to)95-99
Number of pages5
JournalFree Radical Research
Volume5
Issue number2
DOIs
Publication statusPublished - 1 Mar 1988

Keywords

  • Leukotrienes
  • Prostaglandins
  • Superoxide

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