A comparison of the free radical scavenging activity of leukotrienes and prostaglandins

M. Chopra; J. J. F. Belch; W. E. Smith

doi:10.3109/10715768809066916

A comparison of the free radical scavenging activity of leukotrienes and prostaglandins

M. Chopra^*, J. J. F. Belch, W. E. Smith

^*Corresponding author for this work

School of Pharmacy & Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The relative reactivity of leukotrienes and prostaglandins to free radicals and the superoxide ion generated by the photo oxidation of dianisidine have been assessed in vitro. Leukotrienes are effective general radical scavengers rather than superoxide scavengers, with the order of effectiveness LTD, > LTC₄ > LTB₄. Prostaglandins are relatively unreactive. It is suggested that this susceptibility to free radical attack may be one reason for the formation of chemotactic agents from leukotrienes rather than prostaglandins and this may be one part of the mode of action of these compounds in chronic inflammation.

Original language	English
Pages (from-to)	95-99
Number of pages	5
Journal	Free Radical Research
Volume	5
Issue number	2
DOIs	https://doi.org/10.3109/10715768809066916
Publication status	Published - 1 Mar 1988

Keywords

Leukotrienes
Prostaglandins
Superoxide

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10.3109/10715768809066916

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title = "A comparison of the free radical scavenging activity of leukotrienes and prostaglandins",

abstract = "The relative reactivity of leukotrienes and prostaglandins to free radicals and the superoxide ion generated by the photo oxidation of dianisidine have been assessed in vitro. Leukotrienes are effective general radical scavengers rather than superoxide scavengers, with the order of effectiveness LTD, > LTC4 > LTB4. Prostaglandins are relatively unreactive. It is suggested that this susceptibility to free radical attack may be one reason for the formation of chemotactic agents from leukotrienes rather than prostaglandins and this may be one part of the mode of action of these compounds in chronic inflammation.",

keywords = "Leukotrienes, Prostaglandins, Superoxide",

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AU - Chopra, M.

AU - Belch, J. J. F.

AU - Smith, W. E.

PY - 1988/3/1

Y1 - 1988/3/1

N2 - The relative reactivity of leukotrienes and prostaglandins to free radicals and the superoxide ion generated by the photo oxidation of dianisidine have been assessed in vitro. Leukotrienes are effective general radical scavengers rather than superoxide scavengers, with the order of effectiveness LTD, > LTC4 > LTB4. Prostaglandins are relatively unreactive. It is suggested that this susceptibility to free radical attack may be one reason for the formation of chemotactic agents from leukotrienes rather than prostaglandins and this may be one part of the mode of action of these compounds in chronic inflammation.

AB - The relative reactivity of leukotrienes and prostaglandins to free radicals and the superoxide ion generated by the photo oxidation of dianisidine have been assessed in vitro. Leukotrienes are effective general radical scavengers rather than superoxide scavengers, with the order of effectiveness LTD, > LTC4 > LTB4. Prostaglandins are relatively unreactive. It is suggested that this susceptibility to free radical attack may be one reason for the formation of chemotactic agents from leukotrienes rather than prostaglandins and this may be one part of the mode of action of these compounds in chronic inflammation.

KW - Leukotrienes

KW - Prostaglandins

KW - Superoxide

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DO - 10.3109/10715768809066916

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SP - 95

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JO - Free Radical Research

JF - Free Radical Research

SN - 1071-5762

IS - 2

ER -

A comparison of the free radical scavenging activity of leukotrienes and prostaglandins

Abstract

Keywords

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