A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(II) probe for in vivo imaging of live neurons

Yu Man Ho, Ngan Pan Bennett Au, Ka Leung Wong, Chris Tsz-Leung Chan, Wai Ming Kwok, Ga Lai Law, Kwong Kit Tang, Wai Yeung Wong, Chi Him Eddie Ma, Michael Hon-Wah Lam

Research output: Contribution to journalArticlepeer-review


Real-time tracking of fast axonal transport of acidic vesicles in live adult mouse dorsal root ganglion (DRG) and cortical neurons in brain slices was visualized by the use of binuclear cycloplatinated complexes, ([Pt(L1)]2(μ-dppm))2+ (1) and ([Pt(L2)]2(μ-dppm))2+ (2), as lysosome-specific two-photon imaging probes.

Original languageEnglish
Pages (from-to)4161-4163
Number of pages3
JournalChemical Communications
Issue number32
Early online date3 Jan 2014
Publication statusPublished - 25 Mar 2014

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