A method to design biomimetic scaffolds for bone tissue engineering based on Voronoi lattices

M. Fantini*, M. Curto, F. De Crescenzio

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    Abstract

    In regenerative medicine, 3D scaffolds are used to sustain the regeneration of tissues in removed or damaged parts of the human body. As such practices are being widely experimented in clinical applications, the design, the materials and the manufacturing process to obtain efficient 3D biocompatible lattices are being significantly investigated. Nevertheless, most of the proposed designs are based on regular 3D shapes obtained from the repetition of unit cells disposed in a three-dimensional array. This approach does not exploit the whole potential of computer-aided design tools coupled with manufacturing capabilities for freeform shapes. In this paper, we propose a method to model biomimetic lattices controlling the porosity and the pores size of scaffolds to be integrated with the anatomical shape of the defect. The method has been implemented in bone tissue case study and implements a generative design approach based on Voronoi diagrams.

    Original languageEnglish
    Pages (from-to)77-90
    Number of pages14
    JournalVirtual and Physical Prototyping
    Volume11
    Issue number2
    Early online date19 Apr 2016
    DOIs
    Publication statusPublished - May 2016

    Keywords

    • 3D scaffolds
    • generative design
    • Voronoi diagram

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