A physiologically based pharmacokinetic model for 2,3,7,8-tetrabromodibenzo-p-dioxin (tbdd) in the rat: tissue distribution and cyp1a induction

INIS

• rats 100%
• induction 100%
• tissue distribution 100%
• dioxin 100%
• liver 21%
• doses 17%
• data 13%
• tissues 13%
• fats 13%
• compartments 8%
• skin 8%
• proteins 8%
• dna 8%
• clearance 8%
• excretion 8%
• comparative evaluations 4%
• experimental data 4%
• tools 4%
• interactions 4%
• affinity 4%
• modifications 4%
• diffusion 4%
• blood 4%
• uptake 4%
• receptors 4%
• measured values 4%
• partition 4%
• oral administration 4%
• radioimmunoassay 4%
• feces 4%
• enzyme induction 4%

Pharmacology, Toxicology and Pharmaceutical Science

• Dioxins and Dioxin-Like Compounds 100%
• Pharmacokinetics 100%
• 2,3,7,8-Tetrachlorodibenzodioxin 35%
• CYP1A2 35%
• Binding Protein 11%
• Elimination 5%
• Radioimmunoassay 5%
• Binding Site 5%
• Bromine 5%
• Cytochrome P450 1A1 5%
• Aluminum Hydroxide 5%
• Enzyme Induction 5%
• Aromatic Hydrocarbon Receptor 5%