A rational approach to re-engineer the catalytic efficiency of flavin-dependent halogenases

Binuraj R. K. Menon

doi:10.1016/j.checat.2022.09.044

A rational approach to re-engineer the catalytic efficiency of flavin-dependent halogenases

Binuraj R. K. Menon^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Recently in Nature Catalysis, Prakinee et al. used a novel approach where they re-engineered the hypohalous acid (or HOX) intermediate transfer tunnel of a tryptophan 6-halogenase enzyme to create a catalytically robust and highly efficient variant enzyme.

Original language	English
Pages (from-to)	2434-2437
Number of pages	4
Journal	Chem Catalysis
Volume	2
Issue number	10
DOIs	https://doi.org/10.1016/j.checat.2022.09.044
Publication status	Published - 20 Oct 2022

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10.1016/j.checat.2022.09.044

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title = "A rational approach to re-engineer the catalytic efficiency of flavin-dependent halogenases",

abstract = "Recently in Nature Catalysis, Prakinee et al. used a novel approach where they re-engineered the hypohalous acid (or HOX) intermediate transfer tunnel of a tryptophan 6-halogenase enzyme to create a catalytically robust and highly efficient variant enzyme.",

author = "Menon, \{Binuraj R. K.\}",

note = "Funding Information: This work was supported by the UKRI Synthetic Biology for Growth Programme (SBfG) under grant BB/M017982/1 and by the Royal Society under grant RGS\textbackslash{}R2\textbackslash{}180317 . Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

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AU - Menon, Binuraj R. K.

N1 - Funding Information: This work was supported by the UKRI Synthetic Biology for Growth Programme (SBfG) under grant BB/M017982/1 and by the Royal Society under grant RGS\R2\180317 . Publisher Copyright: © 2022 Elsevier Inc.

PY - 2022/10/20

Y1 - 2022/10/20

N2 - Recently in Nature Catalysis, Prakinee et al. used a novel approach where they re-engineered the hypohalous acid (or HOX) intermediate transfer tunnel of a tryptophan 6-halogenase enzyme to create a catalytically robust and highly efficient variant enzyme.

AB - Recently in Nature Catalysis, Prakinee et al. used a novel approach where they re-engineered the hypohalous acid (or HOX) intermediate transfer tunnel of a tryptophan 6-halogenase enzyme to create a catalytically robust and highly efficient variant enzyme.

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U2 - 10.1016/j.checat.2022.09.044

DO - 10.1016/j.checat.2022.09.044

M3 - Comment/debate

AN - SCOPUS:85140780164

SN - 2667-1107

VL - 2

SP - 2434

EP - 2437

JO - Chem Catalysis

JF - Chem Catalysis

IS - 10

ER -

A rational approach to re-engineer the catalytic efficiency of flavin-dependent halogenases

Abstract

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