A study of cutaneous lesions caused by Leishmania mexicana in plasminogen-deficient mice

Jesús Maldonado; Calcagno Marina; Juan Puig; Zulay Maizo; Luisana Avilan

doi:10.1016/j.yexmp.2005.06.005

A study of cutaneous lesions caused by Leishmania mexicana in plasminogen-deficient mice

Jesús Maldonado, Calcagno Marina, Juan Puig, Zulay Maizo, Luisana Avilan

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The role of plasminogen, the zymogenic form of the serine protease plasmin, was investigated in the infection of Leishmania mexicana in plasminogen-deficient (plg^-/- )and Plg wild-type (plg^+/+) mice. Differences in the lesion size were observed between male plg^+/+ and plg^-/- mice. However, these differences were not observed in female mice. In both genders, examination of the lesion tissues at 8 weeks post-infection showed differences in the immunoreactivity pattern with anti-Leishmania antibodies. The parasites were limited to isolated foci in the plg^-/- mice lesion, in contrast to the scattered pattern observed in plg^+/+ mice. These results support the hypothesis that the interaction of the parasite with the host plasminogen-plasmin system might contribute to the virulence of L. mexicana.

Original language	English
Pages (from-to)	289-294
Number of pages	6
Journal	Experimental and Molecular Pathology
Volume	80
Issue number	3
Early online date	2 Aug 2005
DOIs	https://doi.org/10.1016/j.yexmp.2005.06.005
Publication status	Published - Jun 2006

Keywords

Animals
Female
Host-Parasite Interactions/physiology
Immunohistochemistry
Leishmania mexicana/immunology
Leishmaniasis, Cutaneous/immunology
Male
Mice
Plasminogen/deficiency
Sex Factors

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10.1016/j.yexmp.2005.06.005

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title = "A study of cutaneous lesions caused by Leishmania mexicana in plasminogen-deficient mice",

abstract = "The role of plasminogen, the zymogenic form of the serine protease plasmin, was investigated in the infection of Leishmania mexicana in plasminogen-deficient (plg-/- )and Plg wild-type (plg+/+) mice. Differences in the lesion size were observed between male plg+/+ and plg-/- mice. However, these differences were not observed in female mice. In both genders, examination of the lesion tissues at 8 weeks post-infection showed differences in the immunoreactivity pattern with anti-Leishmania antibodies. The parasites were limited to isolated foci in the plg-/- mice lesion, in contrast to the scattered pattern observed in plg+/+ mice. These results support the hypothesis that the interaction of the parasite with the host plasminogen-plasmin system might contribute to the virulence of L. mexicana.",

keywords = "Animals, Female, Host-Parasite Interactions/physiology, Immunohistochemistry, Leishmania mexicana/immunology, Leishmaniasis, Cutaneous/immunology, Male, Mice, Plasminogen/deficiency, Sex Factors",

author = "Jes{\'u}s Maldonado and Calcagno Marina and Juan Puig and Zulay Maizo and Luisana Avilan",

year = "2006",

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doi = "10.1016/j.yexmp.2005.06.005",

language = "English",

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journal = "Experimental and Molecular Pathology",

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T1 - A study of cutaneous lesions caused by Leishmania mexicana in plasminogen-deficient mice

AU - Maldonado, Jesús

AU - Marina, Calcagno

AU - Puig, Juan

AU - Maizo, Zulay

AU - Avilan, Luisana

PY - 2006/6

Y1 - 2006/6

N2 - The role of plasminogen, the zymogenic form of the serine protease plasmin, was investigated in the infection of Leishmania mexicana in plasminogen-deficient (plg-/- )and Plg wild-type (plg+/+) mice. Differences in the lesion size were observed between male plg+/+ and plg-/- mice. However, these differences were not observed in female mice. In both genders, examination of the lesion tissues at 8 weeks post-infection showed differences in the immunoreactivity pattern with anti-Leishmania antibodies. The parasites were limited to isolated foci in the plg-/- mice lesion, in contrast to the scattered pattern observed in plg+/+ mice. These results support the hypothesis that the interaction of the parasite with the host plasminogen-plasmin system might contribute to the virulence of L. mexicana.

AB - The role of plasminogen, the zymogenic form of the serine protease plasmin, was investigated in the infection of Leishmania mexicana in plasminogen-deficient (plg-/- )and Plg wild-type (plg+/+) mice. Differences in the lesion size were observed between male plg+/+ and plg-/- mice. However, these differences were not observed in female mice. In both genders, examination of the lesion tissues at 8 weeks post-infection showed differences in the immunoreactivity pattern with anti-Leishmania antibodies. The parasites were limited to isolated foci in the plg-/- mice lesion, in contrast to the scattered pattern observed in plg+/+ mice. These results support the hypothesis that the interaction of the parasite with the host plasminogen-plasmin system might contribute to the virulence of L. mexicana.

KW - Animals

KW - Female

KW - Host-Parasite Interactions/physiology

KW - Immunohistochemistry

KW - Leishmania mexicana/immunology

KW - Leishmaniasis, Cutaneous/immunology

KW - Male

KW - Mice

KW - Plasminogen/deficiency

KW - Sex Factors

UR - https://www.sciencedirect.com/science/article/pii/S0014480005000821?via%3Dihub

U2 - 10.1016/j.yexmp.2005.06.005

DO - 10.1016/j.yexmp.2005.06.005

M3 - Article

C2 - 16081064

SN - 0014-4800

VL - 80

SP - 289

EP - 294

JO - Experimental and Molecular Pathology

JF - Experimental and Molecular Pathology

IS - 3

ER -

A study of cutaneous lesions caused by Leishmania mexicana in plasminogen-deficient mice

Abstract

Keywords

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