Acetic acid chromoendoscopy: improving neoplasia detection in Barrett's esophagus

Fergus J. Q. Chedgy, Sharmila Subramaniam, Kesavan Kandiah, Sreedhari Thayalasekaran, Pradeep Bhandari

Research output: Contribution to journalArticlepeer-review

114 Downloads (Pure)

Abstract

Barrett’s esophagus (BE) is an important condition given its significant premalignant potential and dismal five-year survival outcomes of advanced esophageal adenocarcinoma. It is therefore suggested that patients with a diagnosis of BE undergo regular surveillance in order to pick up dysplasia at an earlier stage to improve survival. Current “gold-standard” surveillance protocols suggest targeted biopsy of visible lesions followed by four quadrant random biopsies every 2 cm. However, this method of Barrett’s surveillance is fraught with poor endoscopist compliance as the procedures are time consuming and poorly tolerated by patients. There are also significant miss-rates with this technique for the detection of neoplasia as only 13% of early neoplastic lesions appear as visible nodules. Despite improvements in endoscope resolution these problems persist. Chromoendoscopy is an extremely useful adjunct to enhance mucosal visualization and characterization of Barrett’s mucosa. Acetic acid chromoendoscopy (AAC) is a simple, non-proprietary technique that can significantly improve neoplasia detection rates. This topic highlight summarizes the current evidence base behind AAC for the detection of neoplasia in BE and provides an insight into the direction of travel for further research in this area.
Original languageEnglish
Pages (from-to)5753–5760
Number of pages8
JournalWorld Journal of Gastroenterology
Volume22
Issue number25
DOIs
Publication statusPublished - 7 Jul 2016

Fingerprint

Dive into the research topics of 'Acetic acid chromoendoscopy: improving neoplasia detection in Barrett's esophagus'. Together they form a unique fingerprint.

Cite this