Projects per year
Patients and methods - A “tandem” endoscopy cross-overdesign. Participants will be randomized to endoscopy usingmapping biopsies or AAC, in which dilute acetic acid issprayed onto the surface of the esophagus, highlighting tissuethrough an whitening reaction and enhancing visibilityof areas with cellular changes for biopsy. After 4 to 10weeks, participants will undergo a repeat endoscopy, usingthe second method. Rates of recruitment and retention willbe assessed, in addition to the estimated dysplasia detectionrate, effectiveness of the endoscopist training program,and rates of adverse events (AEs). Qualitative interviewswill explore participant and endoscopist acceptabilityof study design and delivery, and the acceptability ofswitching endoscopic techniques for Barrett's surveillance.
Results - Endoscopists’ ability to diagnose dysplasia in Barrett’sesophagus can be improved. AAC may offer a simple,universally applicable, easily-acquired technique to improvedetection, affording patients earlier diagnosis and treatment,reducing endoscopy time and pathology costs. TheABBA study will determine whether a crossover “tandem”endoscopy design is feasible and acceptable to patientsand clinicians and gather outcome data to power a definitivetrial.
- oesophageal cancer
FingerprintDive into the research topics of 'Acetic acid guided biopsies in Barrett’s surveillance for neoplasia detection versus non-targeted biopsies (Seattle protocol): a feasibility study for a randomised tandem endoscopy trial. The ABBA study.'. Together they form a unique fingerprint.
- 1 Finished
A feasibility study with a crossover design to assess the diagnostic accuracy of acetic acid guided biopsies versus non-targeted biopsies (current practice) for detection of dysplasia during Barrett’s surveillance: The ABBA study
Fogg, C., Dewey, A., Higgins, B., Bhandari, P., Longcroft-Wheaton, G. & Gadeke, L.
1/04/15 → 30/06/16