Acute oxygen sensing in cellular models: relevance to the physiology of pulmonary neuroepithelial and carotid bodies

P. Kemp; G. Searle; M. Hartness; Anthony Lewis; P. Miller; S. Williams; P. Wootten; D. Adriaensen; C. Peers

doi:10.1002/ar.a.10008

Acute oxygen sensing in cellular models: relevance to the physiology of pulmonary neuroepithelial and carotid bodies

P. Kemp, G. Searle, M. Hartness, Anthony Lewis, P. Miller, S. Williams, P. Wootten, D. Adriaensen, C. Peers

School of Pharmacy & Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The combination of studies in native tissues and immortalised model systems during the last decade has made possible a deeper understanding of the physiology and functional morphology of arterial and airway oxygen sensors. Complementary and overlapping information from these earlier studies has allowed a detailed description of the cellular events that link decreased environmental oxygen to the release of physiologically important vasoactive transmitters. Since these basic pathways have now been defined functionally, what remains to be determined is the molecular identity of the specific proteins involved in the signal transduction pathways, and how these proteins interact to produce a full physiological response. With these goals clearly in sight, we have embarked upon a strategy that is a novel combination of proteomics and functional genomics. It is hoped this strategy will enable us to develop and refine the initial models in order to understand more completely the process of oxygen sensing in health and disease.

Original language	English
Pages (from-to)	41-50
Number of pages	10
Journal	The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology
Volume	270A
Issue number	1
DOIs	https://doi.org/10.1002/ar.a.10008
Publication status	Published - 2003

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Kemp, P., Searle, G., Hartness, M., Lewis, A., Miller, P., Williams, S., Wootten, P., Adriaensen, D., & Peers, C. (2003). Acute oxygen sensing in cellular models: relevance to the physiology of pulmonary neuroepithelial and carotid bodies. The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology, 270A(1), 41-50. https://doi.org/10.1002/ar.a.10008

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title = "Acute oxygen sensing in cellular models: relevance to the physiology of pulmonary neuroepithelial and carotid bodies",

abstract = "The combination of studies in native tissues and immortalised model systems during the last decade has made possible a deeper understanding of the physiology and functional morphology of arterial and airway oxygen sensors. Complementary and overlapping information from these earlier studies has allowed a detailed description of the cellular events that link decreased environmental oxygen to the release of physiologically important vasoactive transmitters. Since these basic pathways have now been defined functionally, what remains to be determined is the molecular identity of the specific proteins involved in the signal transduction pathways, and how these proteins interact to produce a full physiological response. With these goals clearly in sight, we have embarked upon a strategy that is a novel combination of proteomics and functional genomics. It is hoped this strategy will enable us to develop and refine the initial models in order to understand more completely the process of oxygen sensing in health and disease.",

author = "P. Kemp and G. Searle and M. Hartness and Anthony Lewis and P. Miller and S. Williams and P. Wootten and D. Adriaensen and C. Peers",

year = "2003",

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journal = "The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology",

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Kemp, P, Searle, G, Hartness, M, Lewis, A, Miller, P, Williams, S, Wootten, P, Adriaensen, D & Peers, C 2003, 'Acute oxygen sensing in cellular models: relevance to the physiology of pulmonary neuroepithelial and carotid bodies', The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology, vol. 270A, no. 1, pp. 41-50. https://doi.org/10.1002/ar.a.10008

TY - JOUR

T1 - Acute oxygen sensing in cellular models: relevance to the physiology of pulmonary neuroepithelial and carotid bodies

AU - Kemp, P.

AU - Searle, G.

AU - Hartness, M.

AU - Lewis, Anthony

AU - Miller, P.

AU - Williams, S.

AU - Wootten, P.

AU - Adriaensen, D.

AU - Peers, C.

PY - 2003

Y1 - 2003

N2 - The combination of studies in native tissues and immortalised model systems during the last decade has made possible a deeper understanding of the physiology and functional morphology of arterial and airway oxygen sensors. Complementary and overlapping information from these earlier studies has allowed a detailed description of the cellular events that link decreased environmental oxygen to the release of physiologically important vasoactive transmitters. Since these basic pathways have now been defined functionally, what remains to be determined is the molecular identity of the specific proteins involved in the signal transduction pathways, and how these proteins interact to produce a full physiological response. With these goals clearly in sight, we have embarked upon a strategy that is a novel combination of proteomics and functional genomics. It is hoped this strategy will enable us to develop and refine the initial models in order to understand more completely the process of oxygen sensing in health and disease.

AB - The combination of studies in native tissues and immortalised model systems during the last decade has made possible a deeper understanding of the physiology and functional morphology of arterial and airway oxygen sensors. Complementary and overlapping information from these earlier studies has allowed a detailed description of the cellular events that link decreased environmental oxygen to the release of physiologically important vasoactive transmitters. Since these basic pathways have now been defined functionally, what remains to be determined is the molecular identity of the specific proteins involved in the signal transduction pathways, and how these proteins interact to produce a full physiological response. With these goals clearly in sight, we have embarked upon a strategy that is a novel combination of proteomics and functional genomics. It is hoped this strategy will enable us to develop and refine the initial models in order to understand more completely the process of oxygen sensing in health and disease.

U2 - 10.1002/ar.a.10008

DO - 10.1002/ar.a.10008

M3 - Article

SN - 1552-4884

VL - 270A

SP - 41

EP - 50

JO - The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology

JF - The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology

IS - 1

ER -

Acute oxygen sensing in cellular models: relevance to the physiology of pulmonary neuroepithelial and carotid bodies

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