An ANFIS approach to transmembrane protein prediction

Hassan B. Kazemian, Syed A. Yusuf

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    This paper is concerned with transmembrane prediction analysis. Most of novel drug design requires the use of Membrane proteins. Transmembrane protein structure allows pharmaceutical industry to design new drugs based on structural layout. However, laboratory experimental structure determination by X-ray crystallography is difficult to be achieved as the hydrophobic molecules do not crystalize easily. Moreover, the sheer number of proteins demands a computational solution to transmembrane regions identifications. This research therefore presents a novel Adaptive Neural Fuzzy Inference System (ANFIS) approach to predict and analyze of membrane helices in amino acid sequences. The ANFIS technique is implemented to predict membrane helices using sliding window data capturing. The paper uses hydrophobicity and propensity to encode the datasets using the conventional one letter symbol of amino acid residues. The computer simulation results show that the offered ANFIS methodology predicts transmembrane regions with high accuracy for randomly selected proteins.

    Original languageEnglish
    Title of host publicationProceedings of the 2014 IEEE International Conference on Fuzzy Systems, FUZZ-IEEE
    PublisherInstitute of Electrical and Electronics Engineers Inc.
    Pages1360-1365
    Number of pages6
    ISBN (Electronic)978-1479920723
    DOIs
    Publication statusPublished - 4 Sep 2014
    Event2014 IEEE International Conference on Fuzzy Systems - Beijing, China
    Duration: 6 Jul 201411 Jul 2014

    Conference

    Conference2014 IEEE International Conference on Fuzzy Systems
    Abbreviated titleFUZZ-IEEE 2014
    Country/TerritoryChina
    CityBeijing
    Period6/07/1411/07/14

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