An electroactive oligo‐EDOT platform for neural tissue engineering

Kaja I. Ritzau‐Reid, Christopher D. Spicer, Amy Gelmi, Christopher L. Grigsby, James F. Ponder, Victoria Bemmer, Adam Creamer, Ramon Vilar, Andrea Serio, Molly M. Stevens

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The unique electrochemical properties of the conductive polymer poly(3,4‐ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) make it an attractive material for use in neural tissue engineering applications. However, inadequate mechanical properties, and difficulties in processing and lack of biodegradability have hindered progress in this field. Here, the functionality of PEDOT:PSS for neural tissue engineering is improved by incorporating 3,4‐ethylenedioxythiophene (EDOT) oligomers, synthesized using a novel end‐capping strategy, into block co‐polymers. By exploiting end‐functionalized oligoEDOT constructs as macroinitiators for the polymerization of poly(caprolactone), a block co‐polymer is produced that is electroactive, processable, and bio‐compatible. By combining these properties, electroactive fibrous mats are produced for neuronal culture via solution electrospinning and melt electrospinning writing. Importantly, it is also shown that neurite length and branching of neural stem cells can be enhanced on the materials under electrical stimulation, demonstrating the promise of these scaffolds for neural tissue engineering.
Original languageEnglish
Article number2003710
Pages (from-to)1-11
Number of pages11
JournalAdvanced Functional Materials
Issue number42
Early online date14 Aug 2020
Publication statusPublished - 15 Oct 2020


  • RCUK
  • EP/L016737/1
  • MRC
  • MR/K026666/1
  • Wellcome Trust
  • 213949/Z/18/Z
  • 3,4‐ethylenedioxythiophene
  • biomaterials
  • electrospinning
  • neurite outgrowth
  • tissue engineering


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