An investigation of the ionophoric characteristics of destruxin A

M. Hinaje, M. Ford, Lee Banting, Stephen Arkle, B. Khambay

Research output: Contribution to journalArticlepeer-review

Abstract

Destruxin A, a cyclohexadepsipeptide related to the enniatins and beauvericin, exhibits ionophoric properties. Calcium ion mobilization across liposomal membrane barriers, for example, has been demonstrated using the calcium ion-sensitive dyes Arsenazo III and Fura-2. Initial molecular mechanics/molecular dynamics calculations indicate the potential for destruxin A to form a coordination complex with calcium in which the divalent cation is bound at the center of a sandwich formed by two molecules of destruxin A. This novel calcium ion binding may help explain the diverse biological effects exhibited by the destruxins.
Original languageEnglish
Pages (from-to)73-77
Number of pages5
JournalArchives of Biochemistry and Biophysics
Volume405
Issue number1
DOIs
Publication statusPublished - 1 Sep 2002

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