Antifouling activities of N-substituted imides: antimicrobial activities and inhibition of Mytilus edulis phenoloxidase

F. Zentz, Claire Hellio, A. Valla, D. La Broise, Graham Bremer, R. Labia

Research output: Contribution to journalArticlepeer-review

Abstract

In the search for novel biodegradable antifouling agents, a series of imides (N-substituted maleimides and succinimides) have been synthesized. A large majority of N-substituted maleimides and succinimides showed an antimicrobial activity toward gram-positive and gram-negative bacteria and fungi of marine origin with minimal inhibition concentrations in the range of 6 to 24 mg/ml. The imides with an alkyl substituent showed higher activities than aromatic analogues, but structure-activity relationships were not clearly established. Some compounds were powerful inhibitors of Mytilus edulis phenoloxidase. This inhibition was noncompetitive as demonstrated with 2 maleimides, a 3-acetoxy succinimide and a succinimide. Thus, this family of products has potential interest as antifouling agents.
Original languageEnglish
Pages (from-to)431-440
Number of pages10
JournalMarine Biotechnology
Volume4
Issue number4
DOIs
Publication statusPublished - Sep 2002

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