Antifouling activity of meroditerpenoids from the marine brown alga Halidrys siliquosa

G. Culioli, A. Ortalo-Magne, R. Valls, Claire Hellio, A. Clare, L. Piovetti

Research output: Contribution to journalArticlepeer-review

Abstract

Nine tetraprenyltoluquinol-related metabolites (1-9) have been isolated from the organic extract of the temperate brown alga Halidrys siliquosa that exhibits antifouling properties. The planar structure of compounds 1-9 was elucidated on the basis of extensive spectroscopic analysis and by comparison of the data with those of related metabolites. Antifouling and toxicity tests were conducted on these compounds: the most active (compounds 2, 6, and 9) inhibited both the growth of four strains of bacteria (MICs < 2.5 mu g/mL) and settlement of cyprids of Balanus amphitrite (EC50 < 5 mu g/mL), the latter at nontoxic concentrations (LC50 > 5 mu g/mL).
Original languageEnglish
Pages (from-to)1121-1126
Number of pages6
JournalJournal of Natural Products
Volume71
Issue number7
DOIs
Publication statusPublished - 2008

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