TY - JOUR
T1 - Azocross-linked poly(acrylic acid) for colonic delivery and adhesion specificity
T2 - Synthesis and characterisation
AU - Kakoulides, Elias P.
AU - Smart, John D.
AU - Tsibouklis, John
PY - 1998/3/31
Y1 - 1998/3/31
N2 - A new synthetic pathway to 4,4'-divinylazobenzene is presented together with a procedure for the copolymerisation of this compound with acrylic acid. The chemical structure of the synthesised series of copolymers is examined in the light of infrared spectroscopy results and nuclear magnetic resonance data. The thermal properties of the materials are assessed using a combination of thermal analysis techniques and their swelling behaviour is evaluated at physiologically relevant buffers designed to mimic the gastrointestinal environment.
AB - A new synthetic pathway to 4,4'-divinylazobenzene is presented together with a procedure for the copolymerisation of this compound with acrylic acid. The chemical structure of the synthesised series of copolymers is examined in the light of infrared spectroscopy results and nuclear magnetic resonance data. The thermal properties of the materials are assessed using a combination of thermal analysis techniques and their swelling behaviour is evaluated at physiologically relevant buffers designed to mimic the gastrointestinal environment.
KW - 4,4'-Divinylazobenzene
KW - Azopolymers
KW - Azoreduction
KW - Biodegradable hydrogels
KW - Colon-specific drug delivery
KW - Mucoadhesion
UR - http://www.scopus.com/inward/record.url?scp=0032584124&partnerID=8YFLogxK
U2 - 10.1016/S0168-3659(98)00005-4
DO - 10.1016/S0168-3659(98)00005-4
M3 - Article
C2 - 9743449
AN - SCOPUS:0032584124
VL - 52
SP - 291
EP - 300
JO - Journal of Controlled Release: Official Journal of the Controlled Release Society
JF - Journal of Controlled Release: Official Journal of the Controlled Release Society
SN - 0168-3659
IS - 3
ER -