Pipelines have been extensively implemented for the transport of natural gas and liquid petroleum over large distances as they are safe, convenient, and more economical. However, there are several kind of damages that might happen to the pipeline, for instance erosion, breaking, and dent. Thus, if these faults are not correctly refit will cause significant pipeline demolitions which have a tremendous impact on the environment. Deep learning approaches assist operators to recognize the damages in pipelines in the earliest phases so that they can have a good time for discussion on how to solve the problem and gathering information. In this chapter, some types of threats which usually occur in pipelines are introduced. Moreover, early detection of pipeline threats using deep learning methods combined with classification methods are studied for pipeline safety and damage prevention.