TY - JOUR
T1 - Biofilm formation in total hip arthroplasty
T2 - prevention and treatment
AU - García-Gareta, Elena
AU - Davidson, Christopher
AU - Levin, Alexandra
AU - Coathup, Melanie J.
AU - Blunn, Gordon W.
N1 - Publisher Copyright:
© The Royal Society of Chemistry 2016.
PY - 2016/8/18
Y1 - 2016/8/18
N2 - Biomaterials science is a very active area of research, which has allowed the successful use of implants in the orthopaedic field for over a century. However, implant infection remains a clinical concern as it is associated with extensive patient morbidity and a high economic burden, which is predicted to increase due to an ageing population. Bacteria are able to adhere, colonise and develop into biofilms on the surface of biomaterials making associated infections physiologically different to other post-surgical infections. Unfortunately, biofilms exert increased protection from the host immune system and an increased resistance to antibiotic therapy in comparison to their planktonic counterparts. The aim of this review is to assess the current knowledge on treatments, pathogenesis and the prevention of infections associated with orthopaedic implants, with a focus on total hip arthroplasty.
AB - Biomaterials science is a very active area of research, which has allowed the successful use of implants in the orthopaedic field for over a century. However, implant infection remains a clinical concern as it is associated with extensive patient morbidity and a high economic burden, which is predicted to increase due to an ageing population. Bacteria are able to adhere, colonise and develop into biofilms on the surface of biomaterials making associated infections physiologically different to other post-surgical infections. Unfortunately, biofilms exert increased protection from the host immune system and an increased resistance to antibiotic therapy in comparison to their planktonic counterparts. The aim of this review is to assess the current knowledge on treatments, pathogenesis and the prevention of infections associated with orthopaedic implants, with a focus on total hip arthroplasty.
UR - http://www.scopus.com/inward/record.url?scp=85016438127&partnerID=8YFLogxK
UR - https://discovery.ucl.ac.uk/id/eprint/1551196/
U2 - 10.1039/c6ra09583f
DO - 10.1039/c6ra09583f
M3 - Article
AN - SCOPUS:85016438127
SN - 2046-2069
VL - 6
SP - 80244
EP - 80261
JO - RSC Advances
JF - RSC Advances
IS - 83
ER -