Biomanufacturing of customized modular scaffolds for critical bone defects

Bahattin Koc, Anil A. Acar, Andrew Weightman, Glen Cooper, Gordon Blunn, Paulo Bartolo

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There is a significant unmet clinical need for modular and customized porous biodegradable constructs (scaffolds) for non-union large bone loss injuries. This paper proposes modelling and biomanufacturing of modular and customizable porous constructs for patient-specific critical bone defects. A computational geometry-based algorithm was developed to model modular porous constructs using a parametric femur model based on the frequency of common injuries. The generated modular constructs are used to generate biomimetic path planning for three-dimensional (3D) printing of modular scaffold pieces. The developed method can be used for regenerating bone tissue for treating non-union large bone defects.
Original languageEnglish
Pages (from-to)209-212
Number of pages4
JournalCIRP Annals - Manufacturing Technology
Issue number1
Early online date15 May 2019
Publication statusPublished - 1 Jun 2019


  • RCUK
  • EP/R015139/1


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