Biosynthesis and characterization of Acalypha indica mediated copper oxide nanoparticles and evaluation of its antimicrobial and anticancer activity

Rajeshwari Sivaraj*, Pattanathu K.S.M. Rahman, P. Rajiv, S. Narendhran, R. Venckatesh

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Copper oxide nanoparticles were synthesized by biological method using aqueous extract of Acalypha indica leaf and characterized by UV-visible spectroscopy, XRD, FT-IR, SEM TEM and EDX analysis. The synthesised particles were highly stable, spherical and particle size was in the range of 26-30 nm. The antimicrobial activity of A. indica mediated copper oxide nanoparticles was tested against selected pathogens. Copper oxide nanoparticles showed efficient antibacterial and antifungal effect against Escherichia coli, Pseudomonas fluorescens and Candida albicans. The cytotoxicity activity of A. indica mediated copper nanoparticles was evaluated by MTT assay against MCF-7 breast cancer cell lines and confirmed that copper oxide nanoparticles have cytotoxicity activity.

Original languageEnglish
Pages (from-to)255-258
Number of pages234
JournalSpectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Volume129
Early online date28 Mar 2014
DOIs
Publication statusPublished - 14 Aug 2014

Keywords

  • Acalypha indica
  • Antimicrobial
  • Biological method
  • Copper oxide nanoparticles
  • Cytotoxicity

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