Biotinylated chitosan-based SPIONs with potential in blood-contacting applications

Vera Balan, Ivona Andreea Petrache, Marcel Ionel Popa, Maria Butnaru, Eugen Barbu, John Tsibouklis, Liliana Verestiuc

Research output: Contribution to journalArticlepeer-review


Haemocompatible biotinylated superparamagnetic nanoparticles (size range 300–700 nm) have been obtained by coating magnetite through ionic gelation with a mixture of chitosan and sodium tripolyphosphate, followed by subsequent functionalisation with biotin. The evaluations of their magnetic properties together with haemocompatibility tests have shown that these nanoparticles exhibit the prerequisite behaviour for use in magnetic field–assisted separations within biological systems.
Original languageEnglish
Pages (from-to)730-743
JournalJournal of Nanoparticle Research
Issue number2
Publication statusPublished - 2012


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