Biotinylated chitosan-based SPIONs with potential in blood-contacting applications

Vera Balan; Ivona Andreea Petrache; Marcel Ionel Popa; Maria Butnaru; Eugen Barbu; John Tsibouklis; Liliana Verestiuc

doi:10.1007/s11051-012-0730-y

Biotinylated chitosan-based SPIONs with potential in blood-contacting applications

Vera Balan, Ivona Andreea Petrache, Marcel Ionel Popa, Maria Butnaru, Eugen Barbu, John Tsibouklis, Liliana Verestiuc

School of Pharmacy & Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Haemocompatible biotinylated superparamagnetic nanoparticles (size range 300–700 nm) have been obtained by coating magnetite through ionic gelation with a mixture of chitosan and sodium tripolyphosphate, followed by subsequent functionalisation with biotin. The evaluations of their magnetic properties together with haemocompatibility tests have shown that these nanoparticles exhibit the prerequisite behaviour for use in magnetic field–assisted separations within biological systems.

Original language	English
Pages (from-to)	730-743
Journal	Journal of Nanoparticle Research
Volume	14
Issue number	2
DOIs	https://doi.org/10.1007/s11051-012-0730-y
Publication status	Published - 2012

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title = "Biotinylated chitosan-based SPIONs with potential in blood-contacting applications",

abstract = "Haemocompatible biotinylated superparamagnetic nanoparticles (size range 300–700 nm) have been obtained by coating magnetite through ionic gelation with a mixture of chitosan and sodium tripolyphosphate, followed by subsequent functionalisation with biotin. The evaluations of their magnetic properties together with haemocompatibility tests have shown that these nanoparticles exhibit the prerequisite behaviour for use in magnetic field–assisted separations within biological systems.",

author = "Vera Balan and Petrache, {Ivona Andreea} and Popa, {Marcel Ionel} and Maria Butnaru and Eugen Barbu and John Tsibouklis and Liliana Verestiuc",

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T1 - Biotinylated chitosan-based SPIONs with potential in blood-contacting applications

AU - Balan, Vera

AU - Petrache, Ivona Andreea

AU - Popa, Marcel Ionel

AU - Butnaru, Maria

AU - Barbu, Eugen

AU - Tsibouklis, John

AU - Verestiuc, Liliana

PY - 2012

Y1 - 2012

N2 - Haemocompatible biotinylated superparamagnetic nanoparticles (size range 300–700 nm) have been obtained by coating magnetite through ionic gelation with a mixture of chitosan and sodium tripolyphosphate, followed by subsequent functionalisation with biotin. The evaluations of their magnetic properties together with haemocompatibility tests have shown that these nanoparticles exhibit the prerequisite behaviour for use in magnetic field–assisted separations within biological systems.

AB - Haemocompatible biotinylated superparamagnetic nanoparticles (size range 300–700 nm) have been obtained by coating magnetite through ionic gelation with a mixture of chitosan and sodium tripolyphosphate, followed by subsequent functionalisation with biotin. The evaluations of their magnetic properties together with haemocompatibility tests have shown that these nanoparticles exhibit the prerequisite behaviour for use in magnetic field–assisted separations within biological systems.

U2 - 10.1007/s11051-012-0730-y

DO - 10.1007/s11051-012-0730-y

M3 - Article

VL - 14

SP - 730

EP - 743

JO - Journal of Nanoparticle Research

JF - Journal of Nanoparticle Research

SN - 1388-0764

IS - 2

ER -

Biotinylated chitosan-based SPIONs with potential in blood-contacting applications

Abstract

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