Abstract
The proto-oncogene c-fos has been isolated as the cellular homolog of the v-fos gene found in the osteosarcoma inducing FBR- and FBJ-murine sarcoma viruses (MSV). Expression of the c-fos gene in transgenic mice leads to the development of bone lesions of which about half progress to bone tumors mainly chondrosarcomas. The tumors display a strong preference for males and have a latency with a mean of 9.5 months. However, also mice without visible lesions develop bone tumors with the same sex preference and latency. These consequences of c-fos expression are independent of the chosen promoter but dependent on a replacement of 3' noncoding sequences of c-fos by a long terminal repeat (LTR) of the FBJ-MSV virus.
Original language | English |
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Pages (from-to) | 861-5 |
Number of pages | 5 |
Journal | Oncogene |
Volume | 4 |
Issue number | 7 |
Publication status | Published - Jul 1989 |
Keywords
- Animals
- Bone Neoplasms
- Female
- Male
- Mice
- Mice, Transgenic
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-fos
- Proto-Oncogenes
- Repetitive Sequences, Nucleic Acid
- Sarcoma Viruses, Murine
- Sex Factors