C-fos expression induces bone tumors in transgenic mice

U. Ruther, D. Komitowski, F. R. Schubert, E. F. Wagner

Research output: Contribution to journalArticlepeer-review

Abstract

The proto-oncogene c-fos has been isolated as the cellular homolog of the v-fos gene found in the osteosarcoma inducing FBR- and FBJ-murine sarcoma viruses (MSV). Expression of the c-fos gene in transgenic mice leads to the development of bone lesions of which about half progress to bone tumors mainly chondrosarcomas. The tumors display a strong preference for males and have a latency with a mean of 9.5 months. However, also mice without visible lesions develop bone tumors with the same sex preference and latency. These consequences of c-fos expression are independent of the chosen promoter but dependent on a replacement of 3' noncoding sequences of c-fos by a long terminal repeat (LTR) of the FBJ-MSV virus.

Original languageEnglish
Pages (from-to)861-5
Number of pages5
JournalOncogene
Volume4
Issue number7
Publication statusPublished - Jul 1989

Keywords

  • Animals
  • Bone Neoplasms
  • Female
  • Male
  • Mice
  • Mice, Transgenic
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-fos
  • Proto-Oncogenes
  • Repetitive Sequences, Nucleic Acid
  • Sarcoma Viruses, Murine
  • Sex Factors

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