Can mesenchymal stem cells survive under normal impaction force in revision total hip replacements?

Michelle Korda, Gordon Blunn, Kirsty Phipps, Philippa Rust, Lucy Di Silvio, Melanie Coathup, Allen Goodship, Jia Hua

Research output: Contribution to journalArticlepeer-review

Abstract

Impaction allograft as a scaffold for bone-forming cells is a tissue-engineering approach for filling bone defects that are commonly encountered during revision total joint replacement (THR). The purpose of this in vitro study is to assess the viability of mesenchymal stem cells (MSC) grown on allograft following impaction using forces similar to those measured during revision total hip replacements. Impaction forces of 0, 3, 6, and 9 kN were used representing normal and high impact. The results showed that the viability in the 3 and 6 kN groups was not significantly reduced compared with that of the 0 kN group, while the survival of the MSCs was significantly reduced after 9 kN impaction force. This study suggests that the addition of MSCs to the allograft scaffold will survive normal impaction force in revision THR.

Original languageEnglish
Pages (from-to)625-30
Number of pages6
JournalTissue Engineering - Part A
Volume12
Issue number3
DOIs
Publication statusPublished - Mar 2006

Keywords

  • Animals
  • Cell Proliferation
  • Cell Survival
  • Cells, Cultured
  • Hip Prosthesis
  • Mesenchymal Stromal Cells
  • Sheep
  • Stress, Mechanical
  • Time Factors
  • Tissue Engineering
  • Transplantation, Homologous

Fingerprint

Dive into the research topics of 'Can mesenchymal stem cells survive under normal impaction force in revision total hip replacements?'. Together they form a unique fingerprint.

Cite this