Carborane-based derivatives of delocalised lipophilic cations for boron neutron capture therapy: synthesis and preliminary in vitro evaluation

Gianpiero Calabrese; A. Gomes; Eugen Barbu; Tom Nevell; John Tsibouklis

doi:10.1039/B806197A

Carborane-based derivatives of delocalised lipophilic cations for boron neutron capture therapy: synthesis and preliminary in vitro evaluation

Gianpiero Calabrese, A. Gomes, Eugen Barbu, Tom Nevell, John Tsibouklis

School of Pharmacy & Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Aimed towards the development and effective delivery of highly boronated antitumour agents for use in the neutron capture therapy of cancer, closo-carboranyl derivatives of Nile blue and salts of dequalinium, rhodamine-123 and tetraphenyl phosphonium incorporating nido-carborane counterions have been synthesized and characterized. A preliminary in vitro evaluation in human cell lines indicated the propensity of these agents to target tumour cells, and to deliver therapeutically relevant quantities of boron.

Original language	English
Pages (from-to)	4864-4871
Number of pages	8
Journal	Journal of Materials Chemistry
Volume	18
Issue number	40
DOIs	https://doi.org/10.1039/B806197A
Publication status	Published - 2008

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title = "Carborane-based derivatives of delocalised lipophilic cations for boron neutron capture therapy: synthesis and preliminary in vitro evaluation",

abstract = "Aimed towards the development and effective delivery of highly boronated antitumour agents for use in the neutron capture therapy of cancer, closo-carboranyl derivatives of Nile blue and salts of dequalinium, rhodamine-123 and tetraphenyl phosphonium incorporating nido-carborane counterions have been synthesized and characterized. A preliminary in vitro evaluation in human cell lines indicated the propensity of these agents to target tumour cells, and to deliver therapeutically relevant quantities of boron.",

author = "Gianpiero Calabrese and A. Gomes and Eugen Barbu and Tom Nevell and John Tsibouklis",

year = "2008",

doi = "10.1039/B806197A",

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journal = "Journal of Materials Chemistry",

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publisher = "Royal Society of Chemistry",

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T1 - Carborane-based derivatives of delocalised lipophilic cations for boron neutron capture therapy: synthesis and preliminary in vitro evaluation

AU - Calabrese, Gianpiero

AU - Gomes, A.

AU - Barbu, Eugen

AU - Nevell, Tom

AU - Tsibouklis, John

PY - 2008

Y1 - 2008

N2 - Aimed towards the development and effective delivery of highly boronated antitumour agents for use in the neutron capture therapy of cancer, closo-carboranyl derivatives of Nile blue and salts of dequalinium, rhodamine-123 and tetraphenyl phosphonium incorporating nido-carborane counterions have been synthesized and characterized. A preliminary in vitro evaluation in human cell lines indicated the propensity of these agents to target tumour cells, and to deliver therapeutically relevant quantities of boron.

AB - Aimed towards the development and effective delivery of highly boronated antitumour agents for use in the neutron capture therapy of cancer, closo-carboranyl derivatives of Nile blue and salts of dequalinium, rhodamine-123 and tetraphenyl phosphonium incorporating nido-carborane counterions have been synthesized and characterized. A preliminary in vitro evaluation in human cell lines indicated the propensity of these agents to target tumour cells, and to deliver therapeutically relevant quantities of boron.

U2 - 10.1039/B806197A

DO - 10.1039/B806197A

M3 - Article

SN - 0959-9428

VL - 18

SP - 4864

EP - 4871

JO - Journal of Materials Chemistry

JF - Journal of Materials Chemistry

IS - 40

ER -

Carborane-based derivatives of delocalised lipophilic cations for boron neutron capture therapy: synthesis and preliminary in vitro evaluation

Abstract

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