Carborane-based derivatives of delocalised lipophilic cations for boron neutron capture therapy: synthesis and preliminary in vitro evaluation

Gianpiero Calabrese, A. Gomes, Eugen Barbu, Tom Nevell, John Tsibouklis

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Aimed towards the development and effective delivery of highly boronated antitumour agents for use in the neutron capture therapy of cancer, closo-carboranyl derivatives of Nile blue and salts of dequalinium, rhodamine-123 and tetraphenyl phosphonium incorporating nido-carborane counterions have been synthesized and characterized. A preliminary in vitro evaluation in human cell lines indicated the propensity of these agents to target tumour cells, and to deliver therapeutically relevant quantities of boron.
    Original languageEnglish
    Pages (from-to)4864-4871
    Number of pages8
    JournalJournal of Materials Chemistry
    Volume18
    Issue number40
    DOIs
    Publication statusPublished - 2008

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