Abstract
Aimed towards the development and effective delivery of highly boronated antitumour agents for use in the neutron capture therapy of cancer, closo-carboranyl derivatives of Nile blue and salts of dequalinium, rhodamine-123 and tetraphenyl phosphonium incorporating nido-carborane counterions have been synthesized and characterized. A preliminary in vitro evaluation in human cell lines indicated the propensity of these agents to target tumour cells, and to deliver therapeutically relevant quantities of boron.
Original language | English |
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Pages (from-to) | 4864-4871 |
Number of pages | 8 |
Journal | Journal of Materials Chemistry |
Volume | 18 |
Issue number | 40 |
DOIs | |
Publication status | Published - 2008 |