Cementless fixation for primary segmental bone tumor endoprostheses

G W Blunn, T W Briggs, S R Cannon, P S Walker, P S Unwin, S Culligan, J P Cobb

Research output: Contribution to journalArticlepeer-review

Abstract

To combat the high incidence of aseptic loosening for young patients and for patients with failed implants after resection for bone tumors, intramedullary cementless fixation of massive tumor implants was investigated. These implants consist of a hydroxyapatite coated titanium stem. To date, 47 of these prostheses have been inserted for the treatment of primary bone tumors. Radiographs indicate that the stems are osseointegrated. Radiolucent lines have not been seen between the implant and the bone. Bone remodeling changes have been observed. In several cases in which the implant was not seated properly on the transaction site, bone grew to the shoulder of the implant. Bone remodeling was particularly evident in stems that were coated over their entire surface. In these cases, the implant induced local bone resorption so that the bone around the midstream region became thinner, with resorption of cortical bone on the periosteal surface and maintenance of bone on the endosteal surface adjacent to the stem. This effect was attributed to stress shielding, and a three-dimensional finite element model using loading data obtained from a telemetry study indicated that, where the stem was bonded to the bone over the entire surface, stresses in the outer cortex became reduced. In the finite element model, reducing the region of hydroxyapatite coating to approximately 1/3 of the stem length reduced the extent of the low-stress area in the outer cortex. Subsequently, prostheses have been coated with hydroxyapatite over only approximately 1/3 of their stem. This method of fixing the massive endoprosthesis to the bone is thought to be successful in the short-term and offers an alternative to cemented fixation.

Original languageEnglish
Pages (from-to)223-30
Number of pages8
JournalClinical Orthopaedics and Related Research
Issue number372
Publication statusPublished - Mar 2000

Keywords

  • Bone Neoplasms
  • Bone and Bones
  • Child
  • Coated Materials, Biocompatible
  • Computer Simulation
  • Durapatite
  • Femoral Neoplasms
  • Finite Element Analysis
  • Humans
  • Humerus
  • Osseointegration
  • Prosthesis Design
  • Prosthesis Implantation
  • Radiography
  • Reoperation
  • Stress, Mechanical
  • Tibia
  • Titanium
  • Research Support, Non-U.S. Gov't

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