Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: a systematic review and meta-analysis

Adam J. Causer; Janis K. Shute; Michael H. Cummings; Anthony I. Shepherd; Mathieu Gruet; Joseph T. Costello; Stephen Bailey; Martin Lindley; Clare Pearson; Gary Connett; Mark I. Allenby; Mary P. Carroll; Thomas Daniels; Zoe L. Saynor

doi:10.1016/j.redox.2020.101436

Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: a systematic review and meta-analysis

Adam J. Causer, Janis K. Shute, Michael H. Cummings, Anthony I. Shepherd, Mathieu Gruet, Joseph T. Costello, Stephen Bailey, Martin Lindley, Clare Pearson, Gary Connett, Mark I. Allenby, Mary P. Carroll, Thomas Daniels, Zoe L. Saynor

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Abstract

Introduction: Oxidative stress may play an important role in the pathophysiology of cystic fibrosis (CF). This review aimed to quantify CF-related redox imbalances.

Methods: Systematic searches of the Medline, CINAHL, CENTRAL and PsycINFO databases were conducted. Mean content of blood biomarkers from people with clinically-stable CF and non-CF controls were used to calculate the standardized mean difference (SMD) and 95% confidence intervals (95% CI).

Results: Forty-nine studies were eligible for this review including a total of 1,792 people with CF and 1,675 controls. Meta-analysis revealed that protein carbonyls (SMD: 1.13, 95% CI: 0.48 to 1.77), total F₂-isoprostane 8-iso-prostaglandin F_2α (SMD: 0.64, 95% CI: 0.23 to 1.05) and malondialdehyde (SMD: 1.34, 95% CI: 0.30 to 2.39) were significantly higher, and vitamins A (SMD: -0.66, 95% CI -1.14 to -0.17) and E (SMD: -0.74, 95% CI: -1.28 to -0.20), β-carotene (SMD: -1.80, 95% CI: -2.92 to -0.67), lutein (SMD: -1.52, 95% CI: -1.83 to -1.20) and albumin (SMD: -0.98, 95% CI: -1.68 to -0.27) were significantly lower in the plasma or serum of people with CF versus controls.

Conclusions: This systematic review and meta-analysis found good evidence for reduced antioxidant capacity and elevated oxidative stress in people with clinically-stable CF.

Original language	English
Article number	101436
Journal	Redox Biology
Volume	32
Early online date	23 Jan 2020
DOIs	https://doi.org/10.1016/j.redox.2020.101436
Publication status	Published - 1 May 2020

Keywords

biological markers
glutathione
minerals
oxidoreductases
redox imbalance
respiratory disease
vitamins

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10.1016/j.redox.2020.101436

Circulating biomarkers of antioxidant status final publishedFinal published version, 1.84 MBLicence: CC BY

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Causer, A. J., Shute, J. K., Cummings, M. H., Shepherd, A. I., Gruet, M., Costello, J. T., Bailey, S., Lindley, M., Pearson, C., Connett, G., Allenby, M. I., Carroll, M. P., Daniels, T., & Saynor, Z. L. (2020). Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: a systematic review and meta-analysis. Redox Biology, 32, Article 101436. https://doi.org/10.1016/j.redox.2020.101436

@article{51e66aa9e38a4496a16728a2ee4f2821,

title = "Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: a systematic review and meta-analysis",

abstract = "Introduction: Oxidative stress may play an important role in the pathophysiology of cystic fibrosis (CF). This review aimed to quantify CF-related redox imbalances.Methods: Systematic searches of the Medline, CINAHL, CENTRAL and PsycINFO databases were conducted. Mean content of blood biomarkers from people with clinically-stable CF and non-CF controls were used to calculate the standardized mean difference (SMD) and 95% confidence intervals (95% CI).Results: Forty-nine studies were eligible for this review including a total of 1,792 people with CF and 1,675 controls. Meta-analysis revealed that protein carbonyls (SMD: 1.13, 95% CI: 0.48 to 1.77), total F2-isoprostane 8-iso-prostaglandin F2α (SMD: 0.64, 95% CI: 0.23 to 1.05) and malondialdehyde (SMD: 1.34, 95% CI: 0.30 to 2.39) were significantly higher, and vitamins A (SMD: -0.66, 95% CI -1.14 to -0.17) and E (SMD: -0.74, 95% CI: -1.28 to -0.20), β-carotene (SMD: -1.80, 95% CI: -2.92 to -0.67), lutein (SMD: -1.52, 95% CI: -1.83 to -1.20) and albumin (SMD: -0.98, 95% CI: -1.68 to -0.27) were significantly lower in the plasma or serum of people with CF versus controls.Conclusions: This systematic review and meta-analysis found good evidence for reduced antioxidant capacity and elevated oxidative stress in people with clinically-stable CF.",

keywords = "biological markers, glutathione, minerals, oxidoreductases, redox imbalance, respiratory disease, vitamins",

author = "Causer, {Adam J.} and Shute, {Janis K.} and Cummings, {Michael H.} and Shepherd, {Anthony I.} and Mathieu Gruet and Costello, {Joseph T.} and Stephen Bailey and Martin Lindley and Clare Pearson and Gary Connett and Allenby, {Mark I.} and Carroll, {Mary P.} and Thomas Daniels and Saynor, {Zoe L.}",

year = "2020",

month = may,

day = "1",

doi = "10.1016/j.redox.2020.101436",

language = "English",

volume = "32",

journal = "Redox Biology",

issn = "2213-2317",

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Causer, AJ, Shute, JK, Cummings, MH , Shepherd, AI, Gruet, M, Costello, JT, Bailey, S, Lindley, M, Pearson, C, Connett, G, Allenby, MI, Carroll, MP, Daniels, T & Saynor, ZL 2020, 'Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: a systematic review and meta-analysis', Redox Biology, vol. 32, 101436. https://doi.org/10.1016/j.redox.2020.101436

TY - JOUR

T1 - Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: a systematic review and meta-analysis

AU - Causer, Adam J.

AU - Shute, Janis K.

AU - Cummings, Michael H.

AU - Shepherd, Anthony I.

AU - Gruet, Mathieu

AU - Costello, Joseph T.

AU - Bailey, Stephen

AU - Lindley, Martin

AU - Pearson, Clare

AU - Connett, Gary

AU - Allenby, Mark I.

AU - Carroll, Mary P.

AU - Daniels, Thomas

AU - Saynor, Zoe L.

PY - 2020/5/1

Y1 - 2020/5/1

N2 - Introduction: Oxidative stress may play an important role in the pathophysiology of cystic fibrosis (CF). This review aimed to quantify CF-related redox imbalances.Methods: Systematic searches of the Medline, CINAHL, CENTRAL and PsycINFO databases were conducted. Mean content of blood biomarkers from people with clinically-stable CF and non-CF controls were used to calculate the standardized mean difference (SMD) and 95% confidence intervals (95% CI).Results: Forty-nine studies were eligible for this review including a total of 1,792 people with CF and 1,675 controls. Meta-analysis revealed that protein carbonyls (SMD: 1.13, 95% CI: 0.48 to 1.77), total F2-isoprostane 8-iso-prostaglandin F2α (SMD: 0.64, 95% CI: 0.23 to 1.05) and malondialdehyde (SMD: 1.34, 95% CI: 0.30 to 2.39) were significantly higher, and vitamins A (SMD: -0.66, 95% CI -1.14 to -0.17) and E (SMD: -0.74, 95% CI: -1.28 to -0.20), β-carotene (SMD: -1.80, 95% CI: -2.92 to -0.67), lutein (SMD: -1.52, 95% CI: -1.83 to -1.20) and albumin (SMD: -0.98, 95% CI: -1.68 to -0.27) were significantly lower in the plasma or serum of people with CF versus controls.Conclusions: This systematic review and meta-analysis found good evidence for reduced antioxidant capacity and elevated oxidative stress in people with clinically-stable CF.

AB - Introduction: Oxidative stress may play an important role in the pathophysiology of cystic fibrosis (CF). This review aimed to quantify CF-related redox imbalances.Methods: Systematic searches of the Medline, CINAHL, CENTRAL and PsycINFO databases were conducted. Mean content of blood biomarkers from people with clinically-stable CF and non-CF controls were used to calculate the standardized mean difference (SMD) and 95% confidence intervals (95% CI).Results: Forty-nine studies were eligible for this review including a total of 1,792 people with CF and 1,675 controls. Meta-analysis revealed that protein carbonyls (SMD: 1.13, 95% CI: 0.48 to 1.77), total F2-isoprostane 8-iso-prostaglandin F2α (SMD: 0.64, 95% CI: 0.23 to 1.05) and malondialdehyde (SMD: 1.34, 95% CI: 0.30 to 2.39) were significantly higher, and vitamins A (SMD: -0.66, 95% CI -1.14 to -0.17) and E (SMD: -0.74, 95% CI: -1.28 to -0.20), β-carotene (SMD: -1.80, 95% CI: -2.92 to -0.67), lutein (SMD: -1.52, 95% CI: -1.83 to -1.20) and albumin (SMD: -0.98, 95% CI: -1.68 to -0.27) were significantly lower in the plasma or serum of people with CF versus controls.Conclusions: This systematic review and meta-analysis found good evidence for reduced antioxidant capacity and elevated oxidative stress in people with clinically-stable CF.

KW - biological markers

KW - glutathione

KW - minerals

KW - oxidoreductases

KW - redox imbalance

KW - respiratory disease

KW - vitamins

U2 - 10.1016/j.redox.2020.101436

DO - 10.1016/j.redox.2020.101436

M3 - Article

SN - 2213-2317

VL - 32

JO - Redox Biology

JF - Redox Biology

M1 - 101436

ER -

Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: a systematic review and meta-analysis

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