Cissampeloflavone, a chalcone-flavone dimer from Cissampelos pareira

Irama Ramirez; Alfredo Carabot; Pablo Melendez; Juan Carmona; Manuel Jimenez; Asmita Sautreau; Trevor A. Crabb; Gerald Blunden; Peter D. Cary; Simon L. Croft; Manuel Costa

doi:10.1016/S0031-9422(03)00241-3

Cissampeloflavone, a chalcone-flavone dimer from Cissampelos pareira

Irama Ramirez, Alfredo Carabot, Pablo Melendez, Juan Carmona, Manuel Jimenez, Asmita Sautreau, Trevor A. Crabb, Gerald Blunden, Peter D. Cary, Simon L. Croft, Manuel Costa

Research output: Contribution to journal › Article › peer-review

Abstract

From the aerial parts of Cissampelos pareira L. (Menispermaceae), a chalcone-flavone dimer has been isolated which, mainly from NMR spectroscopic and MS data, was proved to be 2-(4-hydroxy-3-methoxyphenyl)-7-(4-methoxyphenyl)-6-(2-hydroxy-4,6-dimethoxybenzoyl)-furano[3,2-g]benzopyran-4-one. This has been assigned the trivial name cissampeloflavone. The compound has good activity against Trypanosoma cruzi and T. brucei rhodesiense and has a low toxicity to the human KB cell line.

Original language	English
Pages (from-to)	645-647
Journal	Phytochemistry
Volume	64
Issue number	2
DOIs	https://doi.org/10.1016/S0031-9422(03)00241-3
Publication status	Published - Sept 2003

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title = "Cissampeloflavone, a chalcone-flavone dimer from Cissampelos pareira",

abstract = "From the aerial parts of Cissampelos pareira L. (Menispermaceae), a chalcone-flavone dimer has been isolated which, mainly from NMR spectroscopic and MS data, was proved to be 2-(4-hydroxy-3-methoxyphenyl)-7-(4-methoxyphenyl)-6-(2-hydroxy-4,6-dimethoxybenzoyl)-furano[3,2-g]benzopyran-4-one. This has been assigned the trivial name cissampeloflavone. The compound has good activity against Trypanosoma cruzi and T. brucei rhodesiense and has a low toxicity to the human KB cell line.",

author = "Irama Ramirez and Alfredo Carabot and Pablo Melendez and Juan Carmona and Manuel Jimenez and Asmita Sautreau and Crabb, {Trevor A.} and Gerald Blunden and Cary, {Peter D.} and Croft, {Simon L.} and Manuel Costa",

year = "2003",

month = sep,

doi = "10.1016/S0031-9422(03)00241-3",

language = "English",

volume = "64",

pages = "645--647",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier Limited",

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TY - JOUR

T1 - Cissampeloflavone, a chalcone-flavone dimer from Cissampelos pareira

AU - Ramirez, Irama

AU - Carabot, Alfredo

AU - Melendez, Pablo

AU - Carmona, Juan

AU - Jimenez, Manuel

AU - Sautreau, Asmita

AU - Crabb, Trevor A.

AU - Blunden, Gerald

AU - Cary, Peter D.

AU - Croft, Simon L.

AU - Costa, Manuel

PY - 2003/9

Y1 - 2003/9

N2 - From the aerial parts of Cissampelos pareira L. (Menispermaceae), a chalcone-flavone dimer has been isolated which, mainly from NMR spectroscopic and MS data, was proved to be 2-(4-hydroxy-3-methoxyphenyl)-7-(4-methoxyphenyl)-6-(2-hydroxy-4,6-dimethoxybenzoyl)-furano[3,2-g]benzopyran-4-one. This has been assigned the trivial name cissampeloflavone. The compound has good activity against Trypanosoma cruzi and T. brucei rhodesiense and has a low toxicity to the human KB cell line.

AB - From the aerial parts of Cissampelos pareira L. (Menispermaceae), a chalcone-flavone dimer has been isolated which, mainly from NMR spectroscopic and MS data, was proved to be 2-(4-hydroxy-3-methoxyphenyl)-7-(4-methoxyphenyl)-6-(2-hydroxy-4,6-dimethoxybenzoyl)-furano[3,2-g]benzopyran-4-one. This has been assigned the trivial name cissampeloflavone. The compound has good activity against Trypanosoma cruzi and T. brucei rhodesiense and has a low toxicity to the human KB cell line.

U2 - 10.1016/S0031-9422(03)00241-3

DO - 10.1016/S0031-9422(03)00241-3

M3 - Article

SN - 0031-9422

VL - 64

SP - 645

EP - 647

JO - Phytochemistry

JF - Phytochemistry

IS - 2

ER -

Cissampeloflavone, a chalcone-flavone dimer from Cissampelos pareira

Abstract

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