Cissampeloflavone, a chalcone-flavone dimer from Cissampelos pareira

Irama Ramirez, Alfredo Carabot, Pablo Melendez, Juan Carmona, Manuel Jimenez, Asmita Sautreau, Trevor A. Crabb, Gerald Blunden, Peter D. Cary, Simon L. Croft, Manuel Costa

Research output: Contribution to journalArticlepeer-review


From the aerial parts of Cissampelos pareira L. (Menispermaceae), a chalcone-flavone dimer has been isolated which, mainly from NMR spectroscopic and MS data, was proved to be 2-(4-hydroxy-3-methoxyphenyl)-7-(4-methoxyphenyl)-6-(2-hydroxy-4,6-dimethoxybenzoyl)-furano[3,2-g]benzopyran-4-one. This has been assigned the trivial name cissampeloflavone. The compound has good activity against Trypanosoma cruzi and T. brucei rhodesiense and has a low toxicity to the human KB cell line.
Original languageEnglish
Pages (from-to)645-647
Issue number2
Publication statusPublished - Sept 2003


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