Comparative in vitro surveillance of amoxicillin-clavulanic acid and four oral comparators against 21,232 clinical isolates from Europe

D. Hoban, S. Bouchillon, J. L. Johnson, G. Zhanel, D. Butler, Kay Saunders, L. A. Miller, J. Poupard

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The present study was conducted to determine the in vitro activity of amoxicillin-clavulanic acid compared to that of four newer antimicrobial agents (ampicillin, azithromycin, cefuroxime and trimethoprim-sulfamethoxazole). All of the agents were tested against 21,232 recent clinical isolates encompassing 37 species submitted from 16 European countries between 1997 and 1999. After 20 years of clinical use, amoxicillin-clavulanic acid continues to retain much of its initial activity against targeted gram-positive organisms, selected gram-negative organisms and major respiratory pathogens.
    Original languageEnglish
    Pages (from-to)261-267
    Number of pages7
    JournalEuropean Journal of Clinical Microbiology & Infectious Diseases
    Volume22
    Issue number4
    DOIs
    Publication statusPublished - 2003

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