Comparative in vitro surveillance of amoxicillin-clavulanic acid and four oral comparators against 21,232 clinical isolates from Europe

D. Hoban; S. Bouchillon; J. L. Johnson; G. Zhanel; D. Butler; Kay Saunders; L. A. Miller; J. Poupard

doi:10.1007/s10096-002-0876-0

Comparative in vitro surveillance of amoxicillin-clavulanic acid and four oral comparators against 21,232 clinical isolates from Europe

D. Hoban, S. Bouchillon, J. L. Johnson, G. Zhanel, D. Butler, Kay Saunders, L. A. Miller, J. Poupard

Research output: Contribution to journal › Article › peer-review

Abstract

The present study was conducted to determine the in vitro activity of amoxicillin-clavulanic acid compared to that of four newer antimicrobial agents (ampicillin, azithromycin, cefuroxime and trimethoprim-sulfamethoxazole). All of the agents were tested against 21,232 recent clinical isolates encompassing 37 species submitted from 16 European countries between 1997 and 1999. After 20 years of clinical use, amoxicillin-clavulanic acid continues to retain much of its initial activity against targeted gram-positive organisms, selected gram-negative organisms and major respiratory pathogens.

Original language	English
Pages (from-to)	261-267
Number of pages	7
Journal	European Journal of Clinical Microbiology & Infectious Diseases
Volume	22
Issue number	4
DOIs	https://doi.org/10.1007/s10096-002-0876-0
Publication status	Published - 2003

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Hoban, D., Bouchillon, S., Johnson, J. L., Zhanel, G., Butler, D., Saunders, K., Miller, L. A., & Poupard, J. (2003). Comparative in vitro surveillance of amoxicillin-clavulanic acid and four oral comparators against 21,232 clinical isolates from Europe. European Journal of Clinical Microbiology & Infectious Diseases, 22(4), 261-267. https://doi.org/10.1007/s10096-002-0876-0

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abstract = "The present study was conducted to determine the in vitro activity of amoxicillin-clavulanic acid compared to that of four newer antimicrobial agents (ampicillin, azithromycin, cefuroxime and trimethoprim-sulfamethoxazole). All of the agents were tested against 21,232 recent clinical isolates encompassing 37 species submitted from 16 European countries between 1997 and 1999. After 20 years of clinical use, amoxicillin-clavulanic acid continues to retain much of its initial activity against targeted gram-positive organisms, selected gram-negative organisms and major respiratory pathogens.",

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doi = "10.1007/s10096-002-0876-0",

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Hoban, D, Bouchillon, S, Johnson, JL, Zhanel, G, Butler, D, Saunders, K, Miller, LA & Poupard, J 2003, 'Comparative in vitro surveillance of amoxicillin-clavulanic acid and four oral comparators against 21,232 clinical isolates from Europe', European Journal of Clinical Microbiology & Infectious Diseases, vol. 22, no. 4, pp. 261-267. https://doi.org/10.1007/s10096-002-0876-0

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T1 - Comparative in vitro surveillance of amoxicillin-clavulanic acid and four oral comparators against 21,232 clinical isolates from Europe

AU - Hoban, D.

AU - Bouchillon, S.

AU - Johnson, J. L.

AU - Zhanel, G.

AU - Butler, D.

AU - Saunders, Kay

AU - Miller, L. A.

AU - Poupard, J.

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AB - The present study was conducted to determine the in vitro activity of amoxicillin-clavulanic acid compared to that of four newer antimicrobial agents (ampicillin, azithromycin, cefuroxime and trimethoprim-sulfamethoxazole). All of the agents were tested against 21,232 recent clinical isolates encompassing 37 species submitted from 16 European countries between 1997 and 1999. After 20 years of clinical use, amoxicillin-clavulanic acid continues to retain much of its initial activity against targeted gram-positive organisms, selected gram-negative organisms and major respiratory pathogens.

U2 - 10.1007/s10096-002-0876-0

DO - 10.1007/s10096-002-0876-0

M3 - Article

SN - 0934-9723

VL - 22

SP - 261

EP - 267

JO - European Journal of Clinical Microbiology & Infectious Diseases

JF - European Journal of Clinical Microbiology & Infectious Diseases

IS - 4

ER -

Comparative in vitro surveillance of amoxicillin-clavulanic acid and four oral comparators against 21,232 clinical isolates from Europe

Abstract

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