Comparison of LDL fatty acid and carotenoid concentrations and oxidative resistance of LDL in volunteers from countries with different rates of cardiovascular disease

Anthony J. A. Wright, Susan Southon, Mridula Chopra, Anita Meyer-Wenger, Ulrich Moser, Fernando Granado, Begona Olmedilla, Bernice Corridan, Isabelle Hininger, Anne-Marie Roussel, Henk van den Berg, David I. Thurnham

Research output: Contribution to journalArticlepeer-review


Within Europe there are differences in cardiovascular disease (CVD) risk between countries and this might be related to dietary habits. Oxidative modification of LDL is suggested to increase the risk of CVD and both the fatty acid and antioxidant content of LDL can affect its oxidation. In the present study, concentration of LDL fatty acid and antioxidant micronutrients (tocopherols and carotenoids) and ex vivo oxidative resistance of LDL (lag phase) was compared in volunteers from five countries with different fruit and vegetable intakes and reported rates of CVD. Eighty volunteers (forty males, forty females per centre), age range 25–45 years, were recruited from France, Northern Ireland, UK, Republic of Ireland, The Netherlands, and Spain, and their LDL composition and lag phase were measured. There were some differences in LDL carotenoid and α-tocopherol concentrations between countries. α-Tocopherol was low and β- + γ-tocopherol were high (P
Original languageEnglish
Pages (from-to)21-29
Number of pages9
JournalBritish Journal of Nutrition
Issue number1
Publication statusPublished - Jan 2002


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