TY - JOUR
T1 - Comprehensive assessment of physiological responses in women during the ESA dry immersion VIVALDI microgravity simulation
AU - Robin, Adrien
AU - Van Ombergen, Angelique
AU - Laurens, Claire
AU - Bergouignan, Audrey
AU - Vico, Laurence
AU - Linossier, Marie-Thérèse
AU - Pavy-Le Traon, Anne
AU - Kermorgant, Marc
AU - Chopard, Angèle
AU - Py, Guillaume
AU - Green, David Andrew
AU - Tipton, Michael
AU - Choukér, Alexander
AU - Denise, Pierre
AU - Normand, Hervé
AU - Blanc, Stéphane
AU - Simon, Chantal
AU - Rosnet, Elisabeth
AU - Larcher, Françoise
AU - Fernandez, Peter
AU - De Glisezinski, Isabelle
AU - Larrouy, Dominique
AU - Harant-Farrugia, Isabelle
AU - Antunes, Inês
AU - Gauquelin-Koch, Guillemette
AU - Bareille, Marie-Pierre
AU - Billette De Villemeur, Rebecca
AU - Custaud, Marc-Antoine
AU - Navasiolava, Nastassia
PY - 2023/10/9
Y1 - 2023/10/9
N2 - Astronauts in microgravity experience multi-system deconditioning, impacting their inflight efficiency and inducing dysfunctions upon return to Earth gravity. To fill the sex gap of knowledge in the health impact of spaceflights, we simulate microgravity with a 5-day dry immersion in 18 healthy women (ClinicalTrials.gov Identifier: NCT05043974). Here we show that dry immersion rapidly induces a sedentarily-like metabolism shift mimicking the beginning of a metabolic syndrome with a drop in glucose tolerance, an increase in the atherogenic index of plasma, and an impaired lipid profile. Bone remodeling markers suggest a decreased bone formation coupled with an increased bone resorption. Fluid shifts and muscular unloading participate to a marked cardiovascular and sensorimotor deconditioning with decreased orthostatic tolerance, aerobic capacity, and postural balance. Collected datasets provide a comprehensive multi-systemic assessment of dry immersion effects in women and pave the way for future sex-based evaluations of countermeasures.
AB - Astronauts in microgravity experience multi-system deconditioning, impacting their inflight efficiency and inducing dysfunctions upon return to Earth gravity. To fill the sex gap of knowledge in the health impact of spaceflights, we simulate microgravity with a 5-day dry immersion in 18 healthy women (ClinicalTrials.gov Identifier: NCT05043974). Here we show that dry immersion rapidly induces a sedentarily-like metabolism shift mimicking the beginning of a metabolic syndrome with a drop in glucose tolerance, an increase in the atherogenic index of plasma, and an impaired lipid profile. Bone remodeling markers suggest a decreased bone formation coupled with an increased bone resorption. Fluid shifts and muscular unloading participate to a marked cardiovascular and sensorimotor deconditioning with decreased orthostatic tolerance, aerobic capacity, and postural balance. Collected datasets provide a comprehensive multi-systemic assessment of dry immersion effects in women and pave the way for future sex-based evaluations of countermeasures.
U2 - 10.1038/s41467-023-41990-4
DO - 10.1038/s41467-023-41990-4
M3 - Article
SN - 2041-1723
VL - 14
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 6311
ER -