TY - JOUR
T1 - Controlled release of 5-fluorouracil from microporous zeolites
AU - Spanakis, Marios
AU - Bouropoulos, Nikolaos
AU - Theodoropoulos, Dimitrios
AU - Sygellou, Lamprini
AU - Ewart, Sinead
AU - Moschovi, Anastasia Maria
AU - Siokou, Angeliki
AU - Niopas, Ioannis
AU - Kachrimanis, Kyriakos
AU - Nikolakis, Vladimiros
AU - Cox, Paul A.
AU - Vizirianakis, Ioannis S.
AU - Fatouros, Dimitrios G.
PY - 2014/1
Y1 - 2014/1
N2 - Zeolite particles with different pore diameter and particle size were loaded with the model anticancer drug 5-fluorouracil. The loaded zeolites were characterized by means of SEM, XRD, DSC, XPS, N2 physisorption and FT-IR. Higher loading of 5-FU was observed for NaX-FAU than BEA. Release studies were carried out in HCl 0.1 N. Release of 5-FU from NaX-FAU showed exponential-type behaviour with the drug fully released within 10 min. In the case of BEA, the kinetics of 5-FU shows a multi-step profile with prolonged release over time. Molecular dynamics simulations showed that diffusion of the drug molecule through the BEA framework is lower than for NaX-FAU due to increased van der Waals interaction between the drug and the framework. The effect of zeolitic particles on the viability of Caco-2 monolayers showed that the NaX-FAU particles cause a reduction of cell viability in a more pronounced way compared with the BEA particles.
AB - Zeolite particles with different pore diameter and particle size were loaded with the model anticancer drug 5-fluorouracil. The loaded zeolites were characterized by means of SEM, XRD, DSC, XPS, N2 physisorption and FT-IR. Higher loading of 5-FU was observed for NaX-FAU than BEA. Release studies were carried out in HCl 0.1 N. Release of 5-FU from NaX-FAU showed exponential-type behaviour with the drug fully released within 10 min. In the case of BEA, the kinetics of 5-FU shows a multi-step profile with prolonged release over time. Molecular dynamics simulations showed that diffusion of the drug molecule through the BEA framework is lower than for NaX-FAU due to increased van der Waals interaction between the drug and the framework. The effect of zeolitic particles on the viability of Caco-2 monolayers showed that the NaX-FAU particles cause a reduction of cell viability in a more pronounced way compared with the BEA particles.
U2 - 10.1016/j.nano.2013.06.016
DO - 10.1016/j.nano.2013.06.016
M3 - Article
SN - 1549-9634
VL - 10
SP - 197
EP - 205
JO - Nanomedicine: Nanotechnology, Biology and Medicine
JF - Nanomedicine: Nanotechnology, Biology and Medicine
IS - 1
ER -