Controlled release of 5-fluorouracil from microporous zeolites

Marios Spanakis, Nikolaos Bouropoulos, Dimitrios Theodoropoulos, Lamprini Sygellou, Sinead Ewart, Anastasia Maria Moschovi, Angeliki Siokou, Ioannis Niopas, Kyriakos Kachrimanis, Vladimiros Nikolakis, Paul A. Cox, Ioannis S. Vizirianakis, Dimitrios G. Fatouros

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Abstract

Zeolite particles with different pore diameter and particle size were loaded with the model anticancer drug 5-fluorouracil. The loaded zeolites were characterized by means of SEM, XRD, DSC, XPS, N2 physisorption and FT-IR. Higher loading of 5-FU was observed for NaX-FAU than BEA. Release studies were carried out in HCl 0.1 N. Release of 5-FU from NaX-FAU showed exponential-type behaviour with the drug fully released within 10 min. In the case of BEA, the kinetics of 5-FU shows a multi-step profile with prolonged release over time. Molecular dynamics simulations showed that diffusion of the drug molecule through the BEA framework is lower than for NaX-FAU due to increased van der Waals interaction between the drug and the framework. The effect of zeolitic particles on the viability of Caco-2 monolayers showed that the NaX-FAU particles cause a reduction of cell viability in a more pronounced way compared with the BEA particles.
Original languageEnglish
Pages (from-to)197-205
JournalNanomedicine: Nanotechnology, Biology and Medicine
Volume10
Issue number1
Early online date3 Aug 2013
DOIs
Publication statusPublished - Jan 2014

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