Controlled release of 5-fluorouracil from microporous zeolites

Marios Spanakis; Nikolaos Bouropoulos; Dimitrios Theodoropoulos; Lamprini Sygellou; Sinead Ewart; Anastasia Maria Moschovi; Angeliki Siokou; Ioannis Niopas; Kyriakos Kachrimanis; Vladimiros Nikolakis; Paul A. Cox; Ioannis S. Vizirianakis; Dimitrios G. Fatouros

doi:10.1016/j.nano.2013.06.016

Controlled release of 5-fluorouracil from microporous zeolites

Marios Spanakis
, Nikolaos Bouropoulos
, Dimitrios Theodoropoulos
, Lamprini Sygellou
, Sinead Ewart
, Anastasia Maria Moschovi
, Angeliki Siokou
, Ioannis Niopas
, Kyriakos Kachrimanis
, Vladimiros Nikolakis
, Paul A. Cox
, Ioannis S. Vizirianakis
, Dimitrios G. Fatouros

Research output: Contribution to journal › Article › peer-review

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Abstract

Zeolite particles with different pore diameter and particle size were loaded with the model anticancer drug 5-fluorouracil. The loaded zeolites were characterized by means of SEM, XRD, DSC, XPS, N2 physisorption and FT-IR. Higher loading of 5-FU was observed for NaX-FAU than BEA. Release studies were carried out in HCl 0.1 N. Release of 5-FU from NaX-FAU showed exponential-type behaviour with the drug fully released within 10 min. In the case of BEA, the kinetics of 5-FU shows a multi-step profile with prolonged release over time. Molecular dynamics simulations showed that diffusion of the drug molecule through the BEA framework is lower than for NaX-FAU due to increased van der Waals interaction between the drug and the framework. The effect of zeolitic particles on the viability of Caco-2 monolayers showed that the NaX-FAU particles cause a reduction of cell viability in a more pronounced way compared with the BEA particles.

Original language	English
Pages (from-to)	197-205
Journal	Nanomedicine: Nanotechnology, Biology and Medicine
Volume	10
Issue number	1
Early online date	3 Aug 2013
DOIs	https://doi.org/10.1016/j.nano.2013.06.016
Publication status	Published - Jan 2014

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.nano.2013.06.016

5fuAccepted author manuscript (Post-print), 1.2 MBLicence: CC BY-NC-ND

https://www.sciencedirect.com/science/article/pii/S1549963413003523?via%3Dihub

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Spanakis, M., Bouropoulos, N., Theodoropoulos, D., Sygellou, L., Ewart, S., Moschovi, A. M., Siokou, A., Niopas, I., Kachrimanis, K., Nikolakis, V., Cox, P. A., Vizirianakis, I. S., & Fatouros, D. G. (2014). Controlled release of 5-fluorouracil from microporous zeolites. Nanomedicine: Nanotechnology, Biology and Medicine, 10(1), 197-205. https://doi.org/10.1016/j.nano.2013.06.016

@article{6070466edc264f86960c59ad52c328af,

title = "Controlled release of 5-fluorouracil from microporous zeolites",

abstract = "Zeolite particles with different pore diameter and particle size were loaded with the model anticancer drug 5-fluorouracil. The loaded zeolites were characterized by means of SEM, XRD, DSC, XPS, N2 physisorption and FT-IR. Higher loading of 5-FU was observed for NaX-FAU than BEA. Release studies were carried out in HCl 0.1 N. Release of 5-FU from NaX-FAU showed exponential-type behaviour with the drug fully released within 10 min. In the case of BEA, the kinetics of 5-FU shows a multi-step profile with prolonged release over time. Molecular dynamics simulations showed that diffusion of the drug molecule through the BEA framework is lower than for NaX-FAU due to increased van der Waals interaction between the drug and the framework. The effect of zeolitic particles on the viability of Caco-2 monolayers showed that the NaX-FAU particles cause a reduction of cell viability in a more pronounced way compared with the BEA particles.",

author = "Marios Spanakis and Nikolaos Bouropoulos and Dimitrios Theodoropoulos and Lamprini Sygellou and Sinead Ewart and Moschovi, \{Anastasia Maria\} and Angeliki Siokou and Ioannis Niopas and Kyriakos Kachrimanis and Vladimiros Nikolakis and Cox, \{Paul A.\} and Vizirianakis, \{Ioannis S.\} and Fatouros, \{Dimitrios G.\}",

year = "2014",

month = jan,

doi = "10.1016/j.nano.2013.06.016",

language = "English",

volume = "10",

pages = "197--205",

journal = "Nanomedicine: Nanotechnology, Biology and Medicine",

issn = "1549-9634",

publisher = "Elsevier Inc.",

number = "1",

}

Spanakis, M, Bouropoulos, N, Theodoropoulos, D, Sygellou, L, Ewart, S, Moschovi, AM, Siokou, A, Niopas, I, Kachrimanis, K, Nikolakis, V, Cox, PA, Vizirianakis, IS & Fatouros, DG 2014, 'Controlled release of 5-fluorouracil from microporous zeolites', Nanomedicine: Nanotechnology, Biology and Medicine, vol. 10, no. 1, pp. 197-205. https://doi.org/10.1016/j.nano.2013.06.016

TY - JOUR

T1 - Controlled release of 5-fluorouracil from microporous zeolites

AU - Spanakis, Marios

AU - Bouropoulos, Nikolaos

AU - Theodoropoulos, Dimitrios

AU - Sygellou, Lamprini

AU - Ewart, Sinead

AU - Moschovi, Anastasia Maria

AU - Siokou, Angeliki

AU - Niopas, Ioannis

AU - Kachrimanis, Kyriakos

AU - Nikolakis, Vladimiros

AU - Cox, Paul A.

AU - Vizirianakis, Ioannis S.

AU - Fatouros, Dimitrios G.

PY - 2014/1

Y1 - 2014/1

N2 - Zeolite particles with different pore diameter and particle size were loaded with the model anticancer drug 5-fluorouracil. The loaded zeolites were characterized by means of SEM, XRD, DSC, XPS, N2 physisorption and FT-IR. Higher loading of 5-FU was observed for NaX-FAU than BEA. Release studies were carried out in HCl 0.1 N. Release of 5-FU from NaX-FAU showed exponential-type behaviour with the drug fully released within 10 min. In the case of BEA, the kinetics of 5-FU shows a multi-step profile with prolonged release over time. Molecular dynamics simulations showed that diffusion of the drug molecule through the BEA framework is lower than for NaX-FAU due to increased van der Waals interaction between the drug and the framework. The effect of zeolitic particles on the viability of Caco-2 monolayers showed that the NaX-FAU particles cause a reduction of cell viability in a more pronounced way compared with the BEA particles.

AB - Zeolite particles with different pore diameter and particle size were loaded with the model anticancer drug 5-fluorouracil. The loaded zeolites were characterized by means of SEM, XRD, DSC, XPS, N2 physisorption and FT-IR. Higher loading of 5-FU was observed for NaX-FAU than BEA. Release studies were carried out in HCl 0.1 N. Release of 5-FU from NaX-FAU showed exponential-type behaviour with the drug fully released within 10 min. In the case of BEA, the kinetics of 5-FU shows a multi-step profile with prolonged release over time. Molecular dynamics simulations showed that diffusion of the drug molecule through the BEA framework is lower than for NaX-FAU due to increased van der Waals interaction between the drug and the framework. The effect of zeolitic particles on the viability of Caco-2 monolayers showed that the NaX-FAU particles cause a reduction of cell viability in a more pronounced way compared with the BEA particles.

U2 - 10.1016/j.nano.2013.06.016

DO - 10.1016/j.nano.2013.06.016

M3 - Article

SN - 1549-9634

VL - 10

SP - 197

EP - 205

JO - Nanomedicine: Nanotechnology, Biology and Medicine

JF - Nanomedicine: Nanotechnology, Biology and Medicine

IS - 1

ER -

Controlled release of 5-fluorouracil from microporous zeolites

Abstract

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