TY - JOUR
T1 - Correlation between MMP-9 and extracellular cytokine HMGB1 in prediction of human ischemic stroke outcome
AU - Sapojnikova, Nelly
AU - Kartvelishvili, Tamar
AU - Asatiani, Nino
AU - Zinkevich, Vitaly
AU - Kalandadze, Iagor
AU - Gugutsidze, Darejan
AU - Shakarishvili, Roman
AU - Tsiskaridze, Alexander
N1 - NOTICE: this is the author’s version of a work that was accepted for publication in Biochimica et Biophysica Acta. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Biochimica et Biophysica Acta, [VOL1842, ISSUE9, (2014)] DOI: 10.1016/j.bbadis.2014.04.031
PY - 2014/9/1
Y1 - 2014/9/1
N2 - Ischemic stroke (IS) outcome predictors include clinical features, biochemical parameters and some risk factors. The relations between two main players in the ischemic brain, MMPs and HMGB1, were estimated in the plasma of ischemic stroke patients stratified according to the Glasgow Outcome Scale and the Oxfordshire Community Stroke Project classification. IS patients exhibited higher plasma concentration of MMP-9 and the inflammatory cytokine HMGB1 compared with healthy controls. A full-blown correlation between MMP-9 activation and increased plasma MMP-9 concentration was observed in case of IS patients. A similar activity of MMP-2 and MMP-12 was characteristic of healthy volunteers and IS patients. In patients with ischemic stroke increased plasma levels of MMP-9 and HMGB1 are associated with a poor functional outcome and are significantly correlated with each other (P = 0.0054). We suggest that diagnostic benefits will be obtained if plasma HMGB1 levels are measured for IS patients in addition to MMP-9.
AB - Ischemic stroke (IS) outcome predictors include clinical features, biochemical parameters and some risk factors. The relations between two main players in the ischemic brain, MMPs and HMGB1, were estimated in the plasma of ischemic stroke patients stratified according to the Glasgow Outcome Scale and the Oxfordshire Community Stroke Project classification. IS patients exhibited higher plasma concentration of MMP-9 and the inflammatory cytokine HMGB1 compared with healthy controls. A full-blown correlation between MMP-9 activation and increased plasma MMP-9 concentration was observed in case of IS patients. A similar activity of MMP-2 and MMP-12 was characteristic of healthy volunteers and IS patients. In patients with ischemic stroke increased plasma levels of MMP-9 and HMGB1 are associated with a poor functional outcome and are significantly correlated with each other (P = 0.0054). We suggest that diagnostic benefits will be obtained if plasma HMGB1 levels are measured for IS patients in addition to MMP-9.
U2 - 10.1016/j.bbadis.2014.04.031
DO - 10.1016/j.bbadis.2014.04.031
M3 - Article
SN - 0925-4439
VL - 1842
SP - 1379
EP - 1384
JO - Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
JF - Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
IS - 9
ER -