TY - JOUR
T1 - COVID-19: a promising cure for the global panic
AU - Vellingiri, Balachandar
AU - Jayaramayya, Kaavya
AU - Iyer, Mahalaxmi
AU - Narayanasamy, Arul
AU - Govindasamy, Vivekanandan
AU - Giridharan, Bupesh
AU - Ganesan, Singaravelu
AU - Venugopal, Anila
AU - Venkatesan, Dhivya
AU - Ganesan, Harsha
AU - Rajagopalan, Kamarajan
AU - Cho, Ssang-Goo
AU - Senthil Kumar, Nachimuthu
AU - Subramaniam , Mohana Devi
AU - Rahman, Pattanathu
PY - 2020/4/4
Y1 - 2020/4/4
N2 - The novel Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, which is the causative agent of a potentially fatal disease that is of great global public health concern. The outbreak of the new COVID-19 is wreaking havoc worldwide due to inadequate risk assessment regarding the urgency of the situation. The COVID-19 pandemic has entered a dangerous new phase. When compared with SARS and MERS, COVID-19 has spread more rapidly, due to increased globalization and adaptation of the virus in every environment. Slowing the spread of the COVID-19 cases will significantly reduce the strain on the healthcare system of the country by limiting the number of people who are severely sick by COVID-19 and need hospital care. Hence, the recent outburst of COVID-19 highlights an urgent need for therapeutics targeting SARS-CoV-2. Here, we have discussed the structure of virus; varying symptoms among COVID-19, SARS, MERS and the common flu; the probable mechanism behind the infection and its immune response. Further, the current treatment options, drugs available, ongoing trials and recent diagnostics for COVID-19 have been discussed. We suggest traditional Indian medicinal plants as possible novel therapeutic approaches, exclusively targeting SARS-CoV-2 and its pathways.
AB - The novel Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, which is the causative agent of a potentially fatal disease that is of great global public health concern. The outbreak of the new COVID-19 is wreaking havoc worldwide due to inadequate risk assessment regarding the urgency of the situation. The COVID-19 pandemic has entered a dangerous new phase. When compared with SARS and MERS, COVID-19 has spread more rapidly, due to increased globalization and adaptation of the virus in every environment. Slowing the spread of the COVID-19 cases will significantly reduce the strain on the healthcare system of the country by limiting the number of people who are severely sick by COVID-19 and need hospital care. Hence, the recent outburst of COVID-19 highlights an urgent need for therapeutics targeting SARS-CoV-2. Here, we have discussed the structure of virus; varying symptoms among COVID-19, SARS, MERS and the common flu; the probable mechanism behind the infection and its immune response. Further, the current treatment options, drugs available, ongoing trials and recent diagnostics for COVID-19 have been discussed. We suggest traditional Indian medicinal plants as possible novel therapeutic approaches, exclusively targeting SARS-CoV-2 and its pathways.
KW - COVID-19
KW - Coronavirus
KW - cure
KW - medicinal plants
KW - herb
UR - https://www.sciencedirect.com/science/article/pii/S0048969720317903
U2 - 10.1016/j.scitotenv.2020.138277
DO - 10.1016/j.scitotenv.2020.138277
M3 - Article
SN - 0048-9697
JO - Science of the Total Environment
JF - Science of the Total Environment
M1 - 138277
ER -
