COVID-19: a promising cure for the global panic

Balachandar  Vellingiri; Kaavya  Jayaramayya; Mahalaxmi  Iyer; Arul  Narayanasamy; Vivekanandan  Govindasamy; Bupesh  Giridharan; Singaravelu  Ganesan; Anila  Venugopal; Dhivya  Venkatesan; Harsha  Ganesan; Kamarajan  Rajagopalan; Ssang-Goo  Cho; Nachimuthu  Senthil Kumar; Mohana Devi   Subramaniam; Pattanathu Rahman

doi:10.1016/j.scitotenv.2020.138277

COVID-19: a promising cure for the global panic

Balachandar Vellingiri, Kaavya Jayaramayya, Mahalaxmi Iyer, Arul Narayanasamy, Vivekanandan Govindasamy, Bupesh Giridharan, Singaravelu Ganesan, Anila Venugopal, Dhivya Venkatesan, Harsha Ganesan, Kamarajan Rajagopalan, Ssang-Goo Cho, Nachimuthu Senthil Kumar, Mohana Devi Subramaniam , Pattanathu Rahman

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Abstract

The novel Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, which is the causative agent of a potentially fatal disease that is of great global public health concern. The outbreak of the new COVID-19 is wreaking havoc worldwide due to inadequate risk assessment regarding the urgency of the situation. The COVID-19 pandemic has entered a dangerous new phase. When compared with SARS and MERS, COVID-19 has spread more rapidly, due to increased globalization and adaptation of the virus in every environment. Slowing the spread of the COVID-19 cases will significantly reduce the strain on the healthcare system of the country by limiting the number of people who are severely sick by COVID-19 and need hospital care. Hence, the recent outburst of COVID-19 highlights an urgent need for therapeutics targeting SARS-CoV-2. Here, we have discussed the structure of virus; varying symptoms among COVID-19, SARS, MERS and the common flu; the probable mechanism behind the infection and its immune response. Further, the current treatment options, drugs available, ongoing trials and recent diagnostics for COVID-19 have been discussed. We suggest traditional Indian medicinal plants as possible novel therapeutic approaches, exclusively targeting SARS-CoV-2 and its pathways.

Original language	English
Article number	138277
Journal	Science of the Total Environment
Early online date	4 Apr 2020
DOIs	https://doi.org/10.1016/j.scitotenv.2020.138277
Publication status	Early online - 4 Apr 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

COVID-19
Coronavirus
cure
medicinal plants
herb

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10.1016/j.scitotenv.2020.138277

STOTEN_D_20_04893R2_COVID_19_accepted_articleAccepted author manuscript (Post-print), 1.98 MBLicence: CC BY-NC-ND

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Vellingiri, B., Jayaramayya, K., Iyer, M., Narayanasamy, A., Govindasamy, V., Giridharan, B., Ganesan, S., Venugopal, A., Venkatesan, D., Ganesan, H., Rajagopalan, K., Cho, S.-G., Senthil Kumar, N., Subramaniam , M. D., & Rahman, P. (2020). COVID-19: a promising cure for the global panic. Science of the Total Environment, Article 138277. Advance online publication. https://doi.org/10.1016/j.scitotenv.2020.138277

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abstract = "The novel Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, which is the causative agent of a potentially fatal disease that is of great global public health concern. The outbreak of the new COVID-19 is wreaking havoc worldwide due to inadequate risk assessment regarding the urgency of the situation. The COVID-19 pandemic has entered a dangerous new phase. When compared with SARS and MERS, COVID-19 has spread more rapidly, due to increased globalization and adaptation of the virus in every environment. Slowing the spread of the COVID-19 cases will significantly reduce the strain on the healthcare system of the country by limiting the number of people who are severely sick by COVID-19 and need hospital care. Hence, the recent outburst of COVID-19 highlights an urgent need for therapeutics targeting SARS-CoV-2. Here, we have discussed the structure of virus; varying symptoms among COVID-19, SARS, MERS and the common flu; the probable mechanism behind the infection and its immune response. Further, the current treatment options, drugs available, ongoing trials and recent diagnostics for COVID-19 have been discussed. We suggest traditional Indian medicinal plants as possible novel therapeutic approaches, exclusively targeting SARS-CoV-2 and its pathways.",

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AU - Govindasamy, Vivekanandan

AU - Giridharan, Bupesh

AU - Ganesan, Singaravelu

AU - Venugopal, Anila

AU - Venkatesan, Dhivya

AU - Ganesan, Harsha

AU - Rajagopalan, Kamarajan

AU - Cho, Ssang-Goo

AU - Senthil Kumar, Nachimuthu

AU - Subramaniam , Mohana Devi

AU - Rahman, Pattanathu

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N2 - The novel Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, which is the causative agent of a potentially fatal disease that is of great global public health concern. The outbreak of the new COVID-19 is wreaking havoc worldwide due to inadequate risk assessment regarding the urgency of the situation. The COVID-19 pandemic has entered a dangerous new phase. When compared with SARS and MERS, COVID-19 has spread more rapidly, due to increased globalization and adaptation of the virus in every environment. Slowing the spread of the COVID-19 cases will significantly reduce the strain on the healthcare system of the country by limiting the number of people who are severely sick by COVID-19 and need hospital care. Hence, the recent outburst of COVID-19 highlights an urgent need for therapeutics targeting SARS-CoV-2. Here, we have discussed the structure of virus; varying symptoms among COVID-19, SARS, MERS and the common flu; the probable mechanism behind the infection and its immune response. Further, the current treatment options, drugs available, ongoing trials and recent diagnostics for COVID-19 have been discussed. We suggest traditional Indian medicinal plants as possible novel therapeutic approaches, exclusively targeting SARS-CoV-2 and its pathways.

AB - The novel Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, which is the causative agent of a potentially fatal disease that is of great global public health concern. The outbreak of the new COVID-19 is wreaking havoc worldwide due to inadequate risk assessment regarding the urgency of the situation. The COVID-19 pandemic has entered a dangerous new phase. When compared with SARS and MERS, COVID-19 has spread more rapidly, due to increased globalization and adaptation of the virus in every environment. Slowing the spread of the COVID-19 cases will significantly reduce the strain on the healthcare system of the country by limiting the number of people who are severely sick by COVID-19 and need hospital care. Hence, the recent outburst of COVID-19 highlights an urgent need for therapeutics targeting SARS-CoV-2. Here, we have discussed the structure of virus; varying symptoms among COVID-19, SARS, MERS and the common flu; the probable mechanism behind the infection and its immune response. Further, the current treatment options, drugs available, ongoing trials and recent diagnostics for COVID-19 have been discussed. We suggest traditional Indian medicinal plants as possible novel therapeutic approaches, exclusively targeting SARS-CoV-2 and its pathways.

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COVID-19: a promising cure for the global panic

Abstract

UN SDGs

Keywords

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